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Aromatic organic heterocyclic compounds that consist of a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions of the ring, making this ring symmetrical.
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. [Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist. purity: 100%
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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. YKL-5-124 a potent selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM 1300 nM and 3020 nM for CDK7/Mat1/CycH CDK2 and CDK9 respectively displays biochemical and cellular selectivity for CDK7 over CDK12/13. purity: 99%
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50 13 nM) and SHMT2 (IC50 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma. purity: 98%
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Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 uM. purity: 99%
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Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ML221 is a potent apelin /APJ functional antagonist inhibiting apelin-13-mediated activation of APJ with IC50s of 0.70 uM in the cAMP assay and 1.75 uM in the (beta)-arrestin assay and EC80 of 10 nM in both assays. purity: 97%
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