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Pyrazolotriazines

Organic heterocyclic compounds that consist of a pyrazole ring fused with a triazine ring; triazine is an aromatic six-membered ring containing three nitrogen atoms and three carbon atoms.

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1

eMolecules​ Medchem Express / MRK-740 / 5mg / 536983895 / HY-114209 / / 2387510-80-5 / [null] / 464.570 / C25H32N6O3

Medchem Express / MRK-740 / 5mg / 536983895 / HY-114209 / / 2387510-80-5 / [null] / 464.570 / C25H32N6O3

ENCOMPASS_PREFERRED
2

Medchemexpress LLC MRK-740 5mg | 2387510-80-5 | 5 MG

MRK-740 is a potent, selective, substrate-competitive inhibitor of the PRDM9 histone methyltransferase used as a research chemical probe. It shows biochemical potency (IC50 ≈ 80 nM) and reduces PRDM9-dependent H3K4 trimethylation in cells (~0.8 μM).

  • Potent PRDM9 inhibitor with IC50 ≈ 80 nM.
  • Reduces PRDM9-dependent H3K4 trimethylation in cellular assays (~0.8 μM).
  • High reported purity (99.84%).
  • Molecular weight 464.56; formula C25H32N6O3.
  • Supplied as a solid suitable for in vitro and cellular research.

ENCOMPASS_PREFERRED
3

eMolecules​ 6-BROMO-1-METHYLPYRAZOLO 3 5G

5000159489 6-BROMO-1-METHYLPYRAZOLO 3 5G

ENCOMPASS_PREFERRED
4

eMolecules​ Medchem Express / MRK-016 / 5mg / 446255280 / HY-100370 / / 342652-67-9 / MFCD18086893 / 368.401 / C17H20N8O2

Medchem Express / MRK-016 / 5mg / 446255280 / HY-100370 / / 342652-67-9 / MFCD18086893 / 368.401 / C17H20N8O2

ENCOMPASS_PREFERRED
5

Medchemexpress LLC MRK-740 10mg | 2387510-80-5 | 10 MG

MRK-740 is a potent, selective, substrate-competitive inhibitor of the PRDM9 histone methyltransferase (IC50 = 80 nM). It reduces PRDM9-dependent trimethylation of histone H3K4 and is used as a chemical probe in epigenetics and chromatin biology research. Supplied as a 10 mg solid with high reported purity.

  • Potent PRDM9 inhibition (IC50 ≈ 80 nM).
  • Selective substrate-competitive mechanism of action.
  • Suitable as a chemical probe for chromatin and epigenetics studies.
  • Supplied as a solid with high reported purity.

ENCOMPASS_PREFERRED