Pyridines and derivatives
Medchemexpress LLC HC-070 | TRPC4/TRPC5 antagonist | 1628291-95-1 | 99.7% | 475.32 | 50 MG
HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.
- Weakly inhibits TRPC3 (IC50, 1 μM).
- Highly selective for human TRPC4 and TRPC5-containing channels.
- Inhibits lanthanum-activated TRPC5-mediated currents.
- Blocks M2R-activated TRPC1/TRPC4 channels.
- Inhibits TRPC5 currents activated via muscarinic type 1 (M1R).
- Reduces CCK-4 evoked neuronal activity in amygdala slices.
- Decreases anxiety in mice in a standard EPM.
- Reduces fear memory in mice subjected to chronic social stress.
- Reduces marble burying behavior.
- Reduces immobility time in a tail suspension test.
Medchemexpress LLC HC-070 | 1628291-95-1 | 99.7% | 475.32 | 100 MG
HC-070 is a selective antagonist of TRPC4/TRPC5 channels, inhibiting hTRPC5 with an IC50 of 9.3 nM and hTRPC4 with an IC50 of 46 nM. It exhibits over 400-fold selectivity for human TRPC4/5 channels over other examined channels and weakly inhibits TRPC3 (IC50, 1 μM). It blocks various TRPC-mediated currents, including lanthanum-activated hTRPC5 and M2R-activated human TRPC1/TRPC4. In animal models, HC-070 has been shown to reduce CCK-4 evoked neuronal activity in the amygdala, decrease anxiety, and alleviate fear memory and marble burying behavior without affecting locomotor activity.
- Selective TRPC4/TRPC5 antagonist
- High selectivity for human TRPC4/5 channels
- Modulates TRPC-mediated currents
- Reduces neuronal activity
- Decreases anxiety and fear memory
- Reduces marble burying behavior
Medchemexpress LLC HC-070 | 1628291-95-1 | 99.74% | 475.32 | 10 MG
HC-070 is a potent and selective antagonist of TRPC4 and TRPC5 channels, demonstrating IC50s of 9.3 nM for hTRPC5 and 46 nM for hTRPC4. It exhibits high selectivity, with at least 400-fold preference for human TRPC4 and TRPC5-containing channels over other examined channels. This compound also modulates TRPC1/TRPC4 and TRPC1/5 channels and reduces neuronal activity in amygdala slices.
- Inhibits TRPC4/TRPC5 channels.
- Shows high selectivity for TRPC4 and TRPC5-containing channels.
- Modulates TRPC1/TRPC4 and TRPC1/5 channels.
- Reduces neuronal activity in amygdala slices.
- Weakly inhibits TRPC3.
- Inhibits lanthanum-activated TRPC5-mediated currents.
- Blocks M2R-activated TRPC1/TRPC4 channels.
- Inhibits human TRPC5 currents activated via muscarinic type 1 (M1R).
- Suppresses hTRPC4 currents via M2R.