Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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4,306

Apexbio Technology LLC VX-680 (MK-0457,Tozasertib) 639089-54-6 250mg

VX-680 (also known as MK-0457 or tozasertib CAS 639089-54-6) is a small-molecule inhibitor discovered via molecular screening characterized by its broad inhibitory activity against aurora kinases (pan-aurora inhibitor) In addition to targeting aurora kinases VX-680 also inhibits several other kinases including Src GSK3 Flt3 JAK2 and both wild-type and T315I mutant forms of BCR-Abl It exerts its effect by binding to the inactive conformation of non-aurora kinases resulting in suppression of kinase activation In cellular assays and xenograft models VX-680 has demonstrated significant anti-proliferative activity across diverse tumor types such as ovarian renal thyroid oral squamous cell carcinomas CML AML and multiple myeloma supporting its utility in cancer research

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4,307

Apexbio Technology LLC KX2-391 897016-82-9 250mg

KX2-391 (CAS 897016-82-9) is a highly selective non-ATP competitive inhibitor of Src kinase targeting the substrate-binding site rather than the ATP-binding domain With an IC50 of 20 nM against Src KX2-391 suppresses Src-catalyzed phosphorylation of FAK Shc and paxillin as well as Src autophosphorylation without impacting kinases such as PDGFR EGFR JAK1 JAK2 or Lck Additionally KX2-391 inhibits tubulin polymerization by binding to specific sites on the tubulin heterodimer Cellular assays demonstrate growth inhibition in NIH3T3/c-Src527F and SYF/c-Src527F cell lines with GI50 values of 23 nM and 39 nM respectively KX2-391 is utilized in research involving Src-related oncogenic signaling and tumor metastasis