Pyrimidines And Derivatives
eMolecules tert-butyl 5-bromo-4-formyl-7-methyl-indole-1-carboxylate | 1628640-26-5 | | 1g
Pharmablock | tert-butyl 5-bromo-4-formyl-7-methyl-indole-1-carboxylate | 1g | 596622786 | PBW0760 | | 1628640-26-5 | | 338.201 | C15H16BrNO3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
eMolecules Pharmablock / 26-dichloropyrimidine-4-carboxylic acid / 50mg / 784548324 / PBTEN21495 / 0.000 / 16492-28-7 / MFCD02933142 / 192.980 / C5H2Cl2N2O2
Pharmablock / 26-dichloropyrimidine-4-carboxylic acid / 50mg / 784548324 / PBTEN21495 / 0.000 / 16492-28-7 / MFCD02933142 / 192.980 / C5H2Cl2N2O2
Apexbio Technology LLC Camptothecin(Synonyms: CPT, Camptothecine, (+)-Camptothecin, NSC-94600, (S)-(+)-Camptothecin, Topotecin, 20(S)-Camptothecin), 250mg, CAS: 2114454.
Camptothecin (CAS 7689-03-4) is a small molecule inhibitor that selectively targets topoisomerase I exhibiting an IC50 value of 679 nM It causes DNA damage evident by phosphorylation of histone H2AX ( H2AX) leading to tumor cell death and cellular senescence via the ATM-Chk2-p53-p21 signaling pathway Additionally camptothecin induces autophagy through activation of the AMPK-TSC2-mTOR pathway Preclinical studies demonstrate its anti-tumor activity against tumor cell lines such as SMMC-7721 MCF-7 HCT-116 and NSCLC xenografts underscoring its utility in cancer biology research
Apexbio Technology LLC Rofecoxib 162011-90-7 250mg
Rofecoxib (CAS 162011-90-7) is a selective inhibitor of cyclooxygenase-2 (COX-2) designed to provide anti-inflammatory effects with improved gastrointestinal tolerance compared to non-selective NSAIDs It demonstrates potent inhibition of COX-2 in cell-based assays with IC50 values ranging from 18 to 46 nM In osteosarcoma cells Rofecoxib suppresses prostaglandin E2 (PGE2) synthesis (IC50 26 nM) and inhibits recombinant human COX-2 in stably transfected CHO cells (IC50 18 nM) In biochemical assays using purified human COX-2 the IC50 is 0 34 M In vivo Rofecoxib reduces carrageenan-induced edema and hyperalgesia in rats (ID50 1 1 5 mg/kg) It is widely used in studies investigating COX-2-mediated inflammatory pathways and analgesia