Pyrroles
Medchemexpress LLC BI-2852 | 2375482-51-0 | MFCD32197229 | 10 mg
BI-2852 | Purity: 98.74% | Mol Wt: 516.59 | 2375482-51-0 | MFCD32197229 | 10 mg
eMolecules 1029692-15-6 | Medchem Express | LY2452473 | 5mg | 441681954 | HY-114530 | MFCD14666518 | 374.444 | C22H22N4O2
Ambeed | (S)-2-((tert-Butoxycarbonyl)amino)-3-ethoxypropanoic acid | 100mg | 491665418 | A404978 | 104839-00-1 | MFCD06797558 | 233.264 | C10H19NO5
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Medchemexpress LLC JNJ-18038683 | 851376-05-1 | 98.31% | 529.97 | 50 MG
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19 and 8.20 for rat and human 5-HT7 in HEK293 cells. It displaces specific [3H]5-CT binding sites from rat and human 5-HT7 receptor expressed in HEK293 cells with high affinity. In vivo, it dose-dependently suppresses REM sleep.
- High affinity for 5-HT7 receptors (rat and human)
- Antagonizes 5-HT (100 nM)-stimulated adenylyl cyclase activity
- Dose-dependently suppresses REM sleep
- Maintains decreased REM sleep time with repeated administration
![Medchemexpress LLC [2-chloro-3-(trifluoromethyl)phenyl]-[(4R)-1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-4H-triazolo... | 1627902-21-9 | MFCD31556312 | 99.3% | 440.78 g/mol | C18H13ClF4N6O | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000227025.png-250.jpg)
Medchemexpress LLC [2-chloro-3-(trifluoromethyl)phenyl]-[(4R)-1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-4H-triazolo... | 1627902-21-9 | MFCD31556312 | 99.3% | 440.78 g/mol | C18H13ClF4N6O | 10 MG
JNJ-54175446 is a brain-penetrant, selective purine P2X7 receptor antagonist used in central nervous system research and clinical investigations of neuroinflammation and mood disorders. It is characterized by high potency at human and rat P2X7 receptors and is available in both solid and solution formats across multiple package sizes.
- Brain-penetrant P2X7 receptor antagonist.
- High potency: pIC50 8.46 (human), 8.81 (rat).
- Available as solid and DMSO solution; multiple package sizes from 1 mg to 500 mg.
- High reported purity of 99.3%.
- Suitable for in vitro and in vivo CNS pharmacology studies.
eMolecules 172732-68-2 | Medchem Express | Varespladib | 5mg | 446262827 | HY-13402 | MFCD00944812 | 380.4 | C21H20N2O5
Medchem Express | Cbl-b-IN-2 | 5mg | 788478274 | HY-141431 | 2503325-21-9 | 575.584 | C29H30F5N5O2
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Medchemexpress LLC HY-108637 10mg Medchemexpress, PhiKan 083 CAS:880813-36-5 Purity:>98%
Medchemexpress, HY-108637 10mg PhiKan 083 CAS:880813-36-5 PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC TLR7 agonist 3 | 1229024-78-5 | 99.9% | 312.41 g/mol | C18H24N4O | 100 MG
TLR7 agonist 3 is a small-molecule agonist of Toll-like receptor 7 used as a research reagent to stimulate innate immune responses and evaluate anticancer immunomodulatory strategies. It is supplied as a high-purity solid suitable for in vitro and in vivo studies.
- Potent agonist of Toll-like receptor 7 (TLR7) for immune activation studies.
- Applicable for conjugation to targeting ligands to direct activity to specific cell types.
- High purity solid suitable for analytical and biological assays.
- Soluble in DMSO (100 mg/mL) and ethanol (≥50 mg/mL); compatible with common in vivo formulations at ≥2.5 mg/mL.
- Offered in multiple pack sizes including 100 mg for dosing flexibility.
Medchemexpress LLC Ac-feid-cmk (TFA) | 97.1% | 711.08 | 5 MG
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. It inhibits pyroptosis and attenuates septic acute kidney injury (AKI) in vivo, and can suppress the caspy2-mediated noncanonical inflammasome pathway.
- Attenuates mortality during septic shock
- Reduces kidney injury during septic shock
- Inhibits pyroptosis
- Suppresses caspy2-mediated noncanonical inflammasome pathway
Medchemexpress LLC TLR7/8 agonist 3 | 642473-95-8 | 99.9% | 100 MG
TLR7/8 agonist 3 (Compound II) is a potent TLR7 and TLR8 agonist, extracted from patent WO2016057618 (compound of formula (II)). It is intended for research use only.
- Potent TLR7 and TLR8 agonist
- Induces IFN-α and TNF-α in PBMC
- For research use only
- High purity (99.9%)
eMolecules 875320-31-3 | Medchem Express | Quisinostat (dihydrochloride) | 5mg | 761738576 | HY-15433A | MFCD29905457 | 467.4 | C21H28Cl2N6O2
Medchem Express | Quisinostat (dihydrochloride) | 5mg | 761738576 | HY-15433A | 875320-31-3 | MFCD29905457 | 467.400 | C21H28Cl2N6O2
Medchemexpress LLC HY-15440B 5mg Medchemexpress, Fostemsavir Tris CAS:864953-39-9 Purity:>98%
Medchemexpress, HY-15440B 5mg Fostemsavir Tris CAS:864953-39-9 Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.