Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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1,636 – 1,650 of 4,577 results

1,636

Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | C25H25ClN4O2 | 10MG

Bisindolylmaleimide I hydrochloride is a research-grade protein kinase C (PKC) inhibitor supplied as the hydrochloride salt for laboratory use. It is intended for biochemical and cell-based assays and for analytical applications; not for human or veterinary use.

Reversible, cell-permeable inhibitor of PKC with nanomolar potency.
Suitable for biochemical and cell-based assays.
Hydrochloride salt improves solubility in aqueous media.
High reported purity for analytical applications.
Intended for research use only and method development.

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1,637

Medchemexpress LLC Amas (N-α-maleimidoacet-oxysuccinimide ester) | 50 MG

AMAS (N-α-maleimidoacet-oxysuccinimide ester) is a short, non-cleavable heterobifunctional crosslinker containing an N-hydroxysuccinimide (NHS) ester and a maleimide group. It enables covalent conjugation between primary amines and sulfhydryl groups for bioconjugation of proteins, peptides, and other biomolecules. Supplied as a 50 mg package.

Reactive groups: NHS ester (amine-reactive) and maleimide (sulfhydryl-reactive).
Cleavability: non-cleavable crosslinker.
Spacer arm: short spacer for minimal distance between conjugated partners.
Applications: amine-to-sulfhydryl conjugation for protein and peptide labeling.
Packaging: supplied as a 50 mg vial for laboratory use.

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1,638

Medchemexpress LLC Cy5 maleimide | 1437796-65-0 | 98.0% | 641.24 | 25 MG

Cy5 maleimide is a CY dye, a type of cyanine compound. Cyanine compounds are characterized by having two nitrogen atoms connected by an odd number of methyl units. These dyes possess long wavelengths, adjustable absorption and emission, high extinction coefficients, good water solubility, and relatively simple synthesis. CY dyes are frequently used for labeling proteins, antibodies, and small molecular compounds. For protein and antibody labeling, the conjugation can be achieved through a simple mixing reaction.

Possesses long wavelengths
Adjustable absorption and emission
High extinction coefficients
Good water solubility
Relatively simple synthesis
Used for labeling proteins, antibodies, and small molecular compounds
Conjugation for protein and antibody labeling can be achieved through simple mixing reaction

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1,639

Cayman Chemical FluoresceIn-5-maleImIde 10mg

An activated fluorescent molecule (excitation: 494 nm, emission: 519 nm) used for labeling proteins; reacts optimally with sulfhydryl groups on cysteine side chains at pH 7, forming a stable thioether bond

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1,640

Enzo Life Sciences SB-415286 (5mg). CAS: 264218-23-7

Potent and selective inhibitor of GSK-3β (IC50=78nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO, ethanol or methanol. Long Term Storage: -20°C.

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1,641

Selleck Chemical LLC Bisindolylmaleimide I

Bisindolylmaleimide I (GF109203X GO 6850) is a potent PKC inhibitor with IC50 of 20 nM 17 nM 16 nM and 20 nM for PKC PKC I PKC II and PKC in cell-free assays respectively showing more than 3000-fold selectivity for PKC as compared to EGFR PDGFR and insulin receptor

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1,642

Medchemexpress LLC Maleimide-C10-NHS ester | 87981-04-2 | 98.0% | 378.42 | 100 MG

Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Alkyl/ether-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the ubiquitin-proteasome system for selective target protein degradation

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1,643

AdipoGen Bisindolylmaleimide I (5 mg)

Chemical. CAS: 133052-90-1. Formula: C25H24N4O2. MW: 412.5. Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

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1,644

Medchemexpress LLC Bisindolylmaleimide III | 137592-43-9 | 99.0% | 384.43 g/mol | C23H20N4O2 | 10 MG

Bisindolylmaleimide III is a small-molecule research reagent and a potent, selective inhibitor of protein kinase C (PKC), with reported activity against PKCα and interactions with ribosomal S6 protein kinase 1. It is supplied for laboratory research use and is characterized by a molecular formula of C23H20N4O2, molecular weight of 384.43 g/mol, and a manufacturer-stated purity of approximately 98.95%.

Potent and selective PKC inhibitor.
Characterized by molecular weight 384.43 g/mol and formula C23H20N4O2.
High purity suitable for biochemical and cell signaling studies.
Supplied in small-scale quantities for research use.
For research use only; not for human or veterinary use.

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1,645

Revvity Health Sciences Inc HTRF Anti-Europium TBP Maleimide Labeling Reagent, 1 mg

HTRF Anti-Europium TBP Maleimide Labeling Reagent, 1 mg

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1,646

Medchemexpress LLC Cy5 maleimide | 1437796-65-0 | 98.0% | 641.24 | 50 MG

Cy5 maleimide is a CY dye, a type of Cyanine compound characterized by two nitrogen atoms connected by an odd number of methyl units. These dyes are known for their long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility, and relatively simple synthesis. It is commonly utilized for the labeling of proteins, antibodies, and small molecular compounds, offering a straightforward mixing reaction for protein antibody labeling.

Long wavelength
Adjustable absorption and emission
High extinction coefficient
Good water solubility
Relatively simple synthesis
Used for labeling proteins
Used for labeling antibodies
Used for labeling small molecular compounds

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1,647

AdipoGen Bisindolylmaleimide II (5 mg)

Chemical. CAS: 137592-45-1. Formula: C27H26N4O2. MW: 438.5. Protein kinase C (PKC) inhibitor. Binds with reversed orientation to protein kinase A (PKA).

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1,648

Abcam Ro 31-8220 mesylate (Bisindolylmaleimide I x ), Protein kinase inhibitor, 5MG

MW 553.7 Da, Purity >98%. Widely used as a cell-permeable, reversible, competitive protein kinase C inhibitor. Also potently inhibits wide range of kinases inlcuding RSK1, RSK2, PRK2, PKCα, PKD1, MSK1, GSK3β, CDK2-cyclin A and PIM3, as well as PKCα. Also available in simple stock solutions (ab146723) - add 1 ml of water to get an exact, ready-to-use concentration.

The product is subject to the following: Abcam Restricted Use Statement

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1,649

Cayman Chemical N-EthylmaleImIde 25g

A modifier of protein sulfhydryl groups; has commonly been used to inactivate cysteine-containing enzymes in vitro; inhibits prolyl endopeptidase (IC50 = 6.3 µM); alkylates Cys519 in Kv7.4 and activates Kv7.2, Kv7.4, and Kv7.5 in CHO cells at 50 µM

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1,650

Medchemexpress LLC N-Arachidonyl maleimide | 876305-42-9 | 98.3% | 369.54 | 1 ML

N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM. It modulates the effects of 2-arachidonyl glycerol (2-AG) by increasing its endogenous levels in the brain and preventing cerebellar membrane-mediated degradation.

Potent and irreversible monoacylglycerol lipase (MAGL) inhibitor
Modulates effects of 2-arachidonyl glycerol (2-AG)
Increases endogenous levels of 2-AG in the brain
Prevents cerebellar membrane-mediated degradation of 2-AG
Induces hypothermia, antinociception, and catalepsy in vivo when combined with 2-AG

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Pyrrolidines

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Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | C25H25ClN4O2 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amas (N-α-maleimidoacet-oxysuccinimide ester) | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cy5 maleimide | 1437796-65-0 | 98.0% | 641.24 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Maleimide-C10-NHS ester | 87981-04-2 | 98.0% | 378.42 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

AdipoGen Bisindolylmaleimide I (5 mg) Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bisindolylmaleimide III | 137592-43-9 | 99.0% | 384.43 g/mol | C23H20N4O2 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cy5 maleimide | 1437796-65-0 | 98.0% | 641.24 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

AdipoGen Bisindolylmaleimide II (5 mg) Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-Arachidonyl maleimide | 876305-42-9 | 98.3% | 369.54 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More