Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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1,651 – 1,665 of 4,577 results

1,651

Medchemexpress LLC HY-101763A 500mg Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98%

Medchemexpress, HY-101763A 500mg (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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1,652

Selleck Chemical LLC Paritaprevir (ABT-450) S5404-5mg

Paritaprevir (ABT-450) is a nonstructural (NS) protein 3/4A protease inhibitor

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1,653

Strem, An Ascensus Company CAS 1357562-63-0. 50mg. 1-(2S)-1-[(11bS)-26-Dimethyldinaphtho[21-d12-f][132]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea min. 97%. MFCD18827630

CAS 1357562-63-0. 50mg. 1-(2S)-1-[(11bS)-26-Dimethyldinaphtho[21-d12-f][132]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea min. 97%. MFCD18827630. Molecular Weight 536.56. Molecular Formula C32H29N2O4P. Color/form white pwdr. Strem 15-2204. http//www.strem.com/catalog/v/15-2204/

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1,654

Medchemexpress LLC (S,R,S)-AHPC-O-Ph-PEG1-NH2 | 2361117-24-8 | 97.0% | 50 MG

(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized in PROTAC EED degrader-1 (HY-130614), which is a PROTAC targeting EED with a pKD of 9.02.

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1,655

Medchemexpress LLC PROTAC IRAK4 degrader-1 | 2360533-90-8 | 99.8% | 50 MG

PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon-based IRAK4 PROTAC. It is composed of an IRAK4 ligand, an E3 ligase ligand, and a PROTAC linker. This product is for research use only.

Cereblon-based IRAK4 PROTAC
Composed of an IRAK4 ligand, an E3 ligase ligand, and a PROTAC linker
Induces IRAK4 protein degradation in OCI-LY-10 cells

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1,656

Medchemexpress LLC (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride | 2376990-26-8 | 99.0% | 632.64 g/mol | C28H43Cl2N5O5S | 5 MG

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride is a von Hippel-Lindau (VHL) ligand building block used in PROTAC and E3 ligase chemistry. Supplied as a high-purity, research-scale solid, it is suitable for synthetic chemistry and ligand design workflows.

VHL ligand used to recruit the von Hippel-Lindau protein.
High reported purity (99.01%).
White to off-white solid physical form.
Available in small research-scale quantities, including 5 MG.
Datasheet, certificate of analysis, and safety data sheet available for characterization and handling.

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1,657

Medchemexpress LLC HY-17584 10mg , Linaclotide CAS:851199-59-2 Purity:98%

Medchemexpress, HY-17584 10mg Linaclotide CAS:851199-59-2 Formula:C59H79N15O21S6 Purity:98% Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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1,658

Medchemexpress LLC Milademetan tosylate hydrate | 2095625-97-9 | 98.9% | 808.74 g/mol | C37H44Cl2FN5O8S | 25 MG

Milademetan tosylate hydrate is the tosylate hydrate salt of milademetan, an orally active MDM2 inhibitor used in preclinical research. It disrupts the p53-MDM2 interaction, inducing G1 cell cycle arrest and apoptosis, and is investigated for acute myeloid leukemia and various solid tumor models. For research use only.

Specific MDM2 inhibitor with p53 pathway activity.
Induces G1 cell cycle arrest and apoptosis in preclinical models.
High purity reported (98.89%) on the COA.
Available in small research quantities, including 25 mg packaging.
Supplied with a datasheet and certificate of analysis for traceability.
Chemical identifiers: CAS 2095625-97-9; formula C37H44Cl2FN5O8S.

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1,659

Medchemexpress LLC CCT251455 | 1400284-80-1 | 99.1% | 503.98 | C26H26ClN7O2 | 10MG

CCT251455 is a potent, selective inhibitor of mitotic kinase monopolar spindle 1 (MPS1) with an IC50 of 3 nM. It exhibits cellular potency (P-MPS1 IC50 ≈ 0.04 μM; GI50 ≈ 0.16 μM) and shows oral pharmacokinetic activity in mouse and rat, making it suitable for preclinical research into mitotic checkpoint signaling and anticancer mechanisms.

Potent MPS1 inhibition, IC50 3 nM.
Demonstrates cellular activity: P-MPS1 IC50 ≈ 0.04 μM and GI50 ≈ 0.16 μM.
Shows oral pharmacokinetic activity in rodent models.
High purity for biochemical and cellular assays.
Available in multiple milligram quantities and as a DMSO solution.
Storage recommendations provided for powder and solution to preserve stability.

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1,660

Sigma Aldrich Fine Chemicals Biosciences Tankyrase 2 849 1166 act

TNKS2 (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) also known as PARP5B tanykyrase-2 or TNKL (GenBank Accession No. NM 025235) amino acids 849-1166 (end) with N-terminal GST-tag MW62kDa expressed in Sf9 cells via a Baculovirus expression system.

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1,661

Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | MFCD00236429 | 98.4% | 448.94 | C25H25ClN4O2 | 5 MG

Bisindolylmaleimide I hydrochloride is a cell-permeable, reversible protein kinase C (PKC) inhibitor that also shows activity against GSK-3. It is supplied as a powder for research and analytical use, with reported potency in the low nanomolar range against PKC isoforms and a high reported purity.

Cell-permeable, reversible PKC inhibitor
Potent activity: IC50 ≈ 16-20 nM for PKC isoforms
Also reported to inhibit GSK-3
High purity (reported 98.4%)
Supplied as a powder in small analytical pack sizes (for example, 1 mg, 5 mg, 10 mg)
Recommended storage: powder at 4°C or -20°C; solutions at -20°C or -80°C

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1,662

Medchemexpress LLC Bisindolylmaleimide XI hydrochloride | 145333-02-4 | MFCD01319127 | 98.0% | 489.01 g/mol | C28H29ClN4O2 | 1 MG

Bisindolylmaleimide XI hydrochloride is a bisindolylmaleimide-class small molecule and a potent inhibitor of protein kinase C (PKC) isoforms. It is supplied as the hydrochloride salt for research use and is used in studies of PKC-dependent signaling and cellular pathways.

Potent PKC inhibitor for biochemical and cellular studies.
Hydrochloride salt form improves solubility for assay preparation.
Available in small research pack sizes (1 mg, 5 mg, 10 mg).
Molecular weight 489.01 g/mol; formula C28H29ClN4O2.
High purity (98.0%) suitable for research applications.

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1,663

Medchemexpress LLC Crocin II | 55750-84-0 | MFCD11111454 | 98.0% | 10 MG

Crocin II is a natural glycoside isolated from Gardenia jasminoides, supplied as a solid research reagent and analytical standard with reported antioxidant, anticancer, and antidepressant activities. The product is characterized by a molecular weight of 814.82 g/mol, CAS number 55750-84-0, and a recorded purity around 98%. Recommended storage is -20°C and protect from light; solubility in DMSO is approximately 25 mg/mL.

Natural glycoside isolated from Gardenia jasminoides
High purity suitable for analytical applications
Molecular weight 814.82 g/mol and CAS 55750-84-0
Soluble in DMSO (≈25 mg/mL) for in vitro use
Storage recommended at -20°C and protect from light

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1,664

Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 g/mol | C69H115N11O17 | 25 MG

Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4-unit polyethylene glycol (PEG) linker containing a valine-citrulline (Val-Cit) dipeptide and a para-aminobenzyl (PAB) self-immolative spacer designed for use in antibody-drug conjugate (ADC) synthesis. It provides a hydrophilic spacer, a protease-cleavable linker for controlled payload release, and an amine handle for conjugation to payloads such as MMAE. Supplied as a purified solid for research use and soluble in DMSO.

Cleavable Val-Cit dipeptide enables protease-mediated payload release.
PAB self-immolative spacer enables rapid payload release after cleavage.
Four-unit PEG spacer increases hydrophilicity and solubility.
Primary amine handle supports site-specific conjugation chemistries.
High purity and characterized molecular weight for reproducible conjugation.
Soluble in DMSO at 100 mg/mL for convenient stock preparation.

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1,665

Medchemexpress LLC N- t-Boc-Aminooxy-PE | 25MG

N- t-Boc-Aminooxy-PE | 25MG

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Pyrrolidines

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Medchemexpress LLC HY-101763A 500mg Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Strem, An Ascensus Company CAS 1357562-63-0. 50mg. 1-(2S)-1-[(11bS)-26-Dimethyldinaphtho[21-d12-f][132]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea min. 97%. MFCD18827630 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-O-Ph-PEG1-NH2 | 2361117-24-8 | 97.0% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PROTAC IRAK4 degrader-1 | 2360533-90-8 | 99.8% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride | 2376990-26-8 | 99.0% | 632.64 g/mol | C28H43Cl2N5O5S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-17584 10mg , Linaclotide CAS:851199-59-2 Purity:98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Milademetan tosylate hydrate | 2095625-97-9 | 98.9% | 808.74 g/mol | C37H44Cl2FN5O8S | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CCT251455 | 1400284-80-1 | 99.1% | 503.98 | C26H26ClN7O2 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | MFCD00236429 | 98.4% | 448.94 | C25H25ClN4O2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bisindolylmaleimide XI hydrochloride | 145333-02-4 | MFCD01319127 | 98.0% | 489.01 g/mol | C28H29ClN4O2 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Crocin II | 55750-84-0 | MFCD11111454 | 98.0% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 g/mol | C69H115N11O17 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N- t-Boc-Aminooxy-PE | 25MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More