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Filtered Search Results
Medchemexpress LLC C12-TLRa | 3067466-15-0 | C46H73N5O2 | 50 MG
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C12-TLRa is an ionized adjuvant lipid that targets TLR7/8 receptors in endosomes. It enhances mRNA delivery as a structural component of LNPs and boosts innate immune responses, making it suitable for research, including SARS-CoV-2 mRNA vaccines. Internally, C12-TLRa LNP (10-40 ng per well) shows dose-dependent mRNA transfection in DC2.4 cells with ~75% encapsulation efficiency. In vivo, C12-TLRa-substituted LNPs (5 μg mRNA per mouse) enhance mRNA transfection at injection sites and inguinal lymph nodes in C57BL/6 mice, significantly increasing mature DCs.
- Targets TLR7/8 receptors in endosomes
- Enhances mRNA delivery as a structural component of LNPs
- Boosts innate immune responses
- Suitable for SARS-CoV-2 mRNA vaccine research
- Dose-dependent mRNA transfection
- Enhances mRNA transfection at injection sites and inguinal lymph nodes
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![eMolecules Medchem Express / VL285 / 5mg / 451965704 / HY-111663 / / 1448188-57-5 / [null] / 532.660 / C29H32N4O4S](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502465560.JPG-250.jpg)
eMolecules Medchem Express / VL285 / 5mg / 451965704 / HY-111663 / / 1448188-57-5 / [null] / 532.660 / C29H32N4O4S
Medchem Express / VL285 / 5mg / 451965704 / HY-111663 / / 1448188-57-5 / [null] / 532.660 / C29H32N4O4S
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Cayman Chemical 9 Z 11 E 13 EOctadecatrienoic
α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.
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Medchemexpress LLC Methyl S---N-Z-aziri 250mg | 104597-98-0 | 235.24 | C12H13NO4 | 250 MG
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Methyl (S)-(-)-N-Z-aziridine-2-carboxylate is a chiral synthetic intermediate used in pharmaceutical and agrochemical research. Supplied in a 250 mg research pack with a reported purity of 98.0%, it is intended for stereoselective transformations and small-scale route development.
- Chiral building block for enantioselective synthesis.
- High reported purity (98.0%).
- Supplied in research-scale pack sizes for flexible use.
- Suitable for medicinal chemistry and process development applications.
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Medchemexpress LLC Boc-NH-PEG2-CH2CH2COOH | 1365655-91-9 | MFCD22056304 | 98.0% | 277.31 g·mol-1 | C12H23NO6 | 500 MG
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Boc-NH-PEG2-CH2CH2COOH is a Boc-protected, PEG-based linker for assembling PROTAC molecules. It combines a two-unit ethylene glycol spacer with a Boc-protected amino terminus and a terminal propionic acid, enabling versatile conjugation chemistry for connecting target ligands and E3 ligase ligands in small-molecule degraders.
- Boc-protected amino terminus for selective deprotection and coupling.
- Two-unit PEG spacer provides flexibility and appropriate linker length.
- Terminal carboxylic acid enables standard amide or ester bond formation.
- High purity suitable for research-grade synthesis workflows.
- Good solubility in DMSO for easy stock solution preparation.
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MEDCHEMEXPRESS LLC TANDOSPIRONE CITRATE 10MG
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501874035 TANDOSPIRONE CITRATE 10MG
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Medchemexpress LLC (Rac)-Reparixin | 957407-64-6 | C14H21NO3S | 1 ML
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(Rac)-Reparixin is a chemical intended for laboratory use and for the manufacture of substances. It is classified with hazards such as acute oral toxicity, skin corrosion/irritation, serious eye damage/eye irritation, and specific target organ toxicity (respiratory tract irritation). This product is for research use only.
- Stable under recommended storage conditions
- Appears as a solid
- Identified for laboratory chemicals and manufacturing of substances
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Selleck Chemical LLC VH298-5mg
VH298 is a potent VHL (Von Hippel-Lindau, the E3 ligase) inhibitor that stabilizes HIF-α. VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry (ITC) and 80 nM in a competitive fluorescence polarization assay. VH-298 can be used in PROTAC technology.
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![Medchemexpress LLC Butanoic acid, 4-[4-fluoro-2-[1-[4-(1-methylethyl)phenyl]-5-phenyl-1H-pyrazol-3-yl]phenoxy]- | 2988135-14-2 | 99.9% | C28H27FN2O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259487.png-250.jpg)
Medchemexpress LLC Butanoic acid, 4-[4-fluoro-2-[1-[4-(1-methylethyl)phenyl]-5-phenyl-1H-pyrazol-3-yl]phenoxy]- | 2988135-14-2 | 99.9% | C28H27FN2O3 | 10MG
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FABPs ligand 6 (MF6) is a research-grade small-molecule inhibitor of fatty acid-binding proteins FABP7 and FABP5. It is used in preclinical studies, including multiple sclerosis and mitochondrial function research, offering a well-characterized tool for biochemical and cellular assays.
- High affinity for FABP7 (KD 20 nM) and FABP5 (KD 874 nM).
- High purity (99.86%) suitable for biochemical assays.
- Soluble in DMSO at high concentration (125 mg/mL) with ultrasonic assistance.
- Solid off-white to light yellow appearance for easy handling.
- Stable in solution when stored at -80°C for extended periods.
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MEDCHEMEXPRESS LLC RI-1 5MG
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501873189 RI-1 5MG
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Medchemexpress LLC 1-Boc-3-(hydroxymethyl)pyrrolidine | 114214-69-6 | 98.5% | C10H19NO3 | 5 G
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1-Boc-3-(hydroxymethyl)pyrrolidine is an intermediate that can be used to synthesize a FGFR1/2/3/4 inhibitor and is applicable in cancer research.
- Can be used to synthesize a FGFR1/2/3/4 inhibitor
- Applicable in cancer research
- Categorized as an intermediate
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Medchemexpress LLC Tyrphostin AG490 | 134036-52-5 | MFCD00236452 | 99.7% | 294.30 | C17H14N2O3 | 1 ML
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(E/Z)-AG490 is a racemic mixture of the E and Z isomers of AG490, a small-molecule tyrosine kinase inhibitor used in biochemical and cellular research. It is employed to probe JAK/STAT signaling and related pathways due to reported inhibition of JAK2/3, STAT3, and EGFR.
- Racemic mixture of E and Z isomers.
- Small-molecule tyrosine kinase inhibitor for signaling research.
- Reported to inhibit JAK2/3, STAT3, and EGFR.
- Available as a concentrated solution for cell-based assays (10 mM in DMSO).
- High purity, 99.71%.
- Molecular weight 294.30 and formula C17H14N2O3.
- Offered in multiple solid and solution formats for assay flexibility.
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eMolecules 2-1-TERT-BUTOXYCARBONYL 25G
5000189139 2-1-TERT-BUTOXYCARBONYL 25G
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AARON CHEMICALS LLC
NC3909337 3-3 4IMETHOXYPHENYLPROPION
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Medchemexpress LLC Bisindolylmaleimide X hydrochloride | 145317-11-9 | MFCD04972010 | 98.9% | 460.96 g/mol | C26H25ClN4O2 | 50 MG
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Bisindolylmaleimide X hydrochloride is a small-molecule kinase inhibitor supplied as a solid for research use. It acts primarily as a potent and selective protein kinase C (PKC) inhibitor and also antagonizes cyclin-dependent kinase 2 (CDK2). The material is provided at high purity for biochemical and cell-based assays.
- Potent protein kinase C (PKC) inhibitor
- Antagonizes cyclin-dependent kinase 2 with reported IC50 ≈ 200 nM
- High purity suitable for biochemical and cell-based studies
- Solid form, available in small laboratory pack sizes
- Useful for kinase signaling and pharmacology research
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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