Pyrrolidines

Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 | C69H115N11O17 | 10 MG

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Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable four-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) synthesis, featuring an amino-terminated PEG4 spacer, a Val-Cit cleavable dipeptide, a PAB self-immolative spacer, and the MMAE payload.

• Cleavable four-unit PEG linker suitable for ADC synthesis.
• Amino-terminated PEG4 spacer enables conjugation.
• Val-Cit dipeptide and PAB spacer allow enzymatic release of MMAE.
• High purity, 99.93%.
• Stored at -20°C, protect from moisture and light.
• Soluble in DMSO at 100 mg/mL; ultrasonic aid recommended.

Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 g/mol | C69H115N11O17 | 25 MG

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Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4-unit polyethylene glycol (PEG) linker containing a valine-citrulline (Val-Cit) dipeptide and a para-aminobenzyl (PAB) self-immolative spacer designed for use in antibody-drug conjugate (ADC) synthesis. It provides a hydrophilic spacer, a protease-cleavable linker for controlled payload release, and an amine handle for conjugation to payloads such as MMAE. Supplied as a purified solid for research use and soluble in DMSO.

• Cleavable Val-Cit dipeptide enables protease-mediated payload release.
• PAB self-immolative spacer enables rapid payload release after cleavage.
• Four-unit PEG spacer increases hydrophilicity and solubility.
• Primary amine handle supports site-specific conjugation chemistries.
• High purity and characterized molecular weight for reproducible conjugation.
• Soluble in DMSO at 100 mg/mL for convenient stock preparation.

Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 g/mol | C69H115N11O17 | 5 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable four-unit PEG linker terminating in an amino group and bearing a Val-Cit-PAB cleavable spacer attached to monomethyl auristatin E (MMAE). It is supplied for research use and is used in the synthesis of antibody-drug conjugates (ADCs).

• Cleavable Val-Cit-PAB spacer linking to MMAE.
• Four-unit PEG spacer with amino terminal.
• High purity: 99.93% (manufacturer reported).
• Molecular weight approximately 1370.71 g/mol.
• Chemical formula: C69H115N11O17.
• Soluble in DMSO; in-vivo formulation guidance provided by manufacturer.
• Store sealed at -20°C; unstable in solution-prepare fresh solutions.

Chemscene ChemScene | Amino-PEG4-Val-Cit-PAB-MMAE | 5MG | CS-0114459 | 0.98 | 1492056-71-9| | 1370.71

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

ChemScene | Amino-PEG4-Val-Cit-PAB-MMAE | 5MG | CS-0114459 | 0.98 | 1492056-71-9| | 1370.71