Pyrrolidines

Medchemexpress LLC Carbamic acid, N-(4-bromobutyl)-, 1,1-dimethylethyl ester | 164365-88-2 | 252.15 | 1 G

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Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. This chemical has a molecular weight of 252.15 and appears as a white to off-white solid below 30°C, becoming a liquid above 32°C. It is designed for research use only.

• Molecular formula: C9H18BrNO2
• Appearance: White to off-white solid below 30°C, liquid above 32°C
• Pure form storage: -20°C for 3 years
• Storage in solvent: -80°C for 6 months, -20°C for 1 month
• Solubility in DMSO: 100 mg/mL

eMolecules​ Ambeed / tert-Butyl (4-bromobutyl)carbamate / 250mg / 525023101 / A123263 / / 164365-88-2 / MFCD06201020 / 252.152 / C9H18BrNO2

Ambeed / tert-Butyl (4-bromobutyl)carbamate / 250mg / 525023101 / A123263 / / 164365-88-2 / MFCD06201020 / 252.152 / C9H18BrNO2

Medchemexpress LLC Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-, (αZ)- | 901787-88-0 | 98.0% | 451.28 | 25 MG

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(Z)-4EGI-1 is the Z-isomer of 4EGI-1, functioning as an inhibitor of eIF4E/eIF4G interaction and translation initiation. It binds effectively to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM, and exhibits anticancer activity. In vitro studies with melanoma cells showed that treatment with (Z)-4EGI-1 significantly reduced the expression of regulatory proteins such as cyclin D1, cyclin E, and Survivin, while housekeeping proteins remained unaffected. It also inhibits the proliferation of cancer cells.

• Functions as an inhibitor of eIF4E/eIF4G interaction and translation initiation.
• Binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM.
• Exhibits anticancer activity.
• Reduces expression of regulatory proteins like cyclin D1, cyclin E, and Survivin.
• Inhibits the proliferation of cancer cells with IC50 values of 15.3 μM for breast cells and 11.6 μM for melanoma cells.

Sigma Aldrich 7-Chloro-4-hydroxy-2-methylquinoline

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