Pyrrolidines
Medchemexpress LLC (E/Z)-Sivopixant | 1640808-39-4 | 98.6% | 507.93 | 1 ML
(E/Z)-Sivopixant is a potent P2X3 receptor antagonist with an IC50 of 4 nM. It is primarily used for respiratory diseases research. P2X3 receptors, expressed in neuroepithelial bodies of the lungs, are involved in information transmission in respiratory organs, including ATP-induced cough.
- Potent P2X3 receptor antagonist
- IC50 of 4 nM
- Used for respiratory diseases research
- Inhibits ATP-induced cough
eMolecules 4-N-Cbz-aminomethylaniline | 168050-39-3 | MFCD03426379 | 1g
Combi-Blocks | 4-N-Cbz-aminomethylaniline | 1g | 267209474 | ST-3355 | 97.000 | 168050-39-3 | MFCD03426379 | 256.305 | C15H16N2O2
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Medchemexpress LLC 1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid | 1193111-39-5 | MFCD20227457 | 92.1% | 406.45 | C13H14N2O7S3 | 25 MG
sulfo-SPDB is a cleavable antibody-drug conjugate (ADC) linker featuring a pyridyldisulfide-based disulfide that is reductively cleavable and a sulfonic acid moiety to improve solubility. It is supplied for research use and is designed for preparing linker-drug intermediates and conjugation to antibodies under controlled, reducing conditions.
- Cleavable disulfide linker enabling reductive release of payload.
- Sulfonic acid group improves aqueous solubility.
- High solubility in DMSO (≥125 mg/mL) for formulation flexibility.
- Compatible with standard ADC conjugation workflows.
- Requires cold storage and protection from light for stability.