Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC NPS-2143 284035-33-2 200mg
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NPS-2143 (CAS 284035-33-2) is a selective antagonist of the calcium-sensing receptor (CaSR) It attenuates the sensitivity of CaSR to extracellular calcium ([Ca2 ]o) thereby modulating downstream signaling and promoting parathyroid hormone (PTH) secretion in vivo In vitro studies demonstrate that NPS-2143 inhibits [Ca2 ]o-induced intracellular calcium signaling in HEK 293T cells expressing CaSR with an EC50 of 4 27 mM for the wild-type receptor It also reduces excessive signal transduction in cells expressing various activating CaSR mutations NPS-2143 is widely utilized in research investigating CaSR function calcium homeostasis and the pharmacological modulation of parathyroid hormone regulation
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000430298 SULFO-CYANINE3 AZIDE 5MG
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eMolecules 70639-78-0 | 2-HYDROXYQUINOLINE-6-CARBOXYLIC ACID | AstaTech | MFCD11007961 | 189.170 | C10H7NO3 | 95.000 | OC(=O)c1ccc2nc(O)ccc2c1 | 1g | 323612351
2-HYDROXYQUINOLINE-6-CARBOXYLIC ACID | AstaTech | 70639-78-0 | MFCD11007961 | 189.170 | C10H7NO3 | 95.000 | OC(=O)c1ccc2nc(O)ccc2c1 | 1g | 323612351
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Medchemexpress LLC GSK547 200mg | 2226735-55-1 | 200 MG
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GSK547 is a potent, selective small-molecule inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1) used in preclinical research to investigate necroptosis, inflammation, and macrophage-mediated immune tolerance. The compound has molecular formula C20H18F2N6O, molecular weight 396.39 g/mol, and vendor-reported purity of 99.92%. It is supplied in research quantities and as solution formulations for experimental use.
- Inhibits RIPK1 with high potency and selectivity.
- Molecular formula C20H18F2N6O; molecular weight 396.39 g/mol.
- Vendor-reported high purity (~99.9%).
- Available as a 200 mg solid and as DMSO solutions (10 mM).
- Suitable for in vitro and preclinical in vivo research applications.
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Apexbio Technology LLC RU.521 2262452-06-0 10mg
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RU 521 (CAS 2262452-06-0) is a selective inhibitor of cyclic GMP-AMP synthase (cGAS) an enzyme responsible for synthesizing cGAMP upon recognition of cytosolic double-stranded DNA By interfering with cGAS-mediated cGAMP production RU 521 suppresses activation of the type I interferon signaling pathway Experimental studies demonstrate that RU 521 reduces cGAS-dependent signal transduction and interferon responses in reporter assays containing double-stranded DNA In macrophages derived from Aicardi-Gouti res syndrome mouse models RU 521 lowers basal interferon expression This compound is a valuable tool for investigating cGAS-dependent innate immune pathways
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TARGETMOL CHEMICALS INC AG490 200MG
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Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50 0.1 uM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src. Purity 99.7%
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Ambeed AMBEED
5000871048 6-BROMOQUINOLINE-3-CARBOXY 1GR
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Aobchem AOBCHEM
5000873928 ETHYL 2- 2-FLUORO-5-ISOPROPOXY
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TARGETMOL CHEMICALS INC Pentamidine 200MG
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Also available in 5 mg, 500 mg and bulk. Please contact Fisher for quotes. Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. Purity 98.13%
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TARGETMOL CHEMICALS INC Methyltetrazine-Amine 25MG
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Also available in 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.Methyltetrazine-Amine is a methyl-substituted tetrazine amine used in the synthesis of PROTAC molecules. Purity 97.59%
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Chemscene CHEMSCENE
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5000580044 7-AZABENZOTRIAZOL-1-YLOXYT 25G
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Medchemexpress LLC Lobeglitazone (sulfate) | 763108-62-9 | 99.6% | 578.61 | 50 MG
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Lobeglitazone sulfate is a new type of thiazolidinedione and an orally active agonist for PPAR with EC50 of 137.4 nM and 546.3 nM for PPARγ and PPARα. It is an inhibitor for the ERK/JNK/Smad/NF-κB signaling pathway and exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties.
- Orally active agonist for PPAR.
- Inhibits the ERK/JNK/Smad/NF-κB signaling pathway.
- Exhibits anti-inflammatory properties.
- Possesses anti-diabetic properties.
- Demonstrates anti-fibrotic and anti-atherosclerotic properties.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000378567 AP-III-A4 200MG
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Alkali Scientific Ethidium Bromide, Powder, 25 G
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Ethidium Bromide (EtBr), 25g, is a powerful DNA stain used in molecular biology for visualizing nucleic acids in electrophoresis gels. Ethidium Bromide intercalates into DNA strands and emits fluorescent light when exposed to UV radiation, enabling clear visualization of DNA bands. The 25g packaging size is perfect for high-throughput laboratories and institutions that require large quantities of stain for DNA analysis. It is widely used in genetic research, PCR experiments, and DNA sequencing to detect DNA fragments in agarose gels, making it a crucial reagent in molecular biology and biochemistry labs.
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Ambeed AMBEED
5000866655 QUINOLIN-6-YLMETHANOL 1GR
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