Quinolines and derivatives

Ambeed Methyl 2 triphenylphosphoranyl

Methyl 2-(triphenylphosphoranylidene)acetate, 2605-67-6, 98%

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Medchemexpress LLC Phentolamine mesylate | 65-28-1 | 99.9% | 500 MG

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Phentolamine mesylate is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors. It expands blood vessels to reduce peripheral vascular resistance and can be used for the research of pheochromocytoma-related hypertension, heart failure, and erectile dysfunction.

• Reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors
• Expands blood vessels to reduce peripheral vascular resistance
• Used for research in pheochromocytoma-related hypertension, heart failure, and erectile dysfunction
• High purity of 99.9%

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Medchemexpress LLC Cephalexin monohydrate | 23325-78-2 | 99.6% | 5 G

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Cephalexin monohydrate is a potent, orally active, new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. It demonstrates antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. It targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly and is used for research related to pneumonia, strep throat, and bacterial endocarditis.

• Potent, orally active new semisynthetic cephalosporin antibiotic
• Broad antibacterial spectrum
• Inhibits a wide variety of gram-positive and gram-negative bacteria
• Disrupts polymer peptidoglycan biogenesis by inactivating penicillin-binding proteins (PBPs)
• Used for research of pneumonia, strep throat, and bacterial endocarditis

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Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | 99.9% | 50 MG

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Trifluoperazine dihydrochloride is an antipsychotic agent that functions by blocking central dopamine receptors. It also acts as a potent α1-adrenergic receptor antagonist and a NUPR1 inhibitor, demonstrating anticancer activity. Furthermore, it is a calmodulin inhibitor and inhibits P-glycoprotein. This compound is utilized in research for schizophrenia and acts as a reversible inhibitor of influenza virus morphogenesis by interfering with cellular CaM and/or CaM-dependent functions.

• Blocks central dopamine receptors
• Potent α1-adrenergic receptor antagonist
• Potent NUPR1 inhibitor with anticancer activity
• Calmodulin inhibitor
• Inhibits P-glycoprotein
• Utilized in research for schizophrenia
• Acts as a reversible inhibitor of influenza virus morphogenesis

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Apexbio Technology LLC MLN120B 783348-36-7 200mg

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MLN120B (CAS 783348-36-7) is a small molecule inhibitor targeting the beta subunit of I B kinase (IKK ) an enzyme integral to the NF- B signaling pathway IKK mediates phosphorylation and subsequent degradation of the NF- B inhibitor I B thereby activating NF- B-dependent transcription involved in inflammatory and immune responses MLN120B inhibits IKK -catalyzed phosphorylation of I B (IC50 20 M) attenuating NF- B activation in multiple myeloma cell lines (RPMI 8226 INA 6 MM 1S) and reducing inflammation-induced joint damage in animal arthritis models Consequently MLN120B serves as a research tool in studying NF- B signaling-mediated disorders

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Medchemexpress LLC BPTES | 314045-39-1 | 98.0% | 200 MG

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BPTES is an allosteric and selective glutaminase inhibitor with an IC50 of 0.16 μM. It is for research use only.

• Inhibits glutaminase activity
• Diminishes glutamate and α-KG levels
• Increases glycolytic intermediates
• Inhibits PDAC cell proliferation
• Slows growth of mutant IDH1 cells
• Shows synergistic anti-cancer effect with 5-FU in A549 and EKVX cell lines
• Reduces growth in most NSCLC cell lines
• Reduces levels of TCA cycle metabolites
• Reduces ATP production
• Attenuates tumor growth in patient-derived pancreatic orthotopic tumor models

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Medchemexpress LLC Azido-PEG8-amine | 857891-82-8 | 99.9% | C18H38N4O8 | 50MG

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Azido-PEG8-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains an Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne group molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• Click chemistry reagent
• Contains an Azide group
• Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
• Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions

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Ambeed 5Methoxy2nitrobenzaldehyde

5-Methoxy-2-nitrobenzaldehyde, 20357-24-8, 98%

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AdipoGen Acridine Orange Sol 2 in H2O

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Chemical. CAS 65-61-2. Formula C17H19N3 . HCl. MW 301.81. Acridine Orange hydrochloride salt is a cell-permeable metachromatic fluorescent dye that stains DNA and RNA. It is used as a nucleic acid-selective fluorescent cationic dye useful for cell cycle determination and staining dead cells. Being cell-permeable, it interacts with DNA and RNA by intercalation or electrostatic attractions respectively. When bound to DNA, it is very similar spectrally to fluorescein, with an excitation maximum at 502nm and an emission maximum at 525nm green. When acridine orange associates with RNA, the excitation maximum shifts to 460nm blue, and the emission maximum shifts to 650nm red. Acridine orange will also enter acidic compartments such as lysosomes where it becomes protonated and sequestered. At low pH inside the organelles, it will emit an orange fluorescence peak at 590nm and for optimal endosome visualization a blue light excitation 475nm is used.

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