Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Tempo 2564-83-2 200mg
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Tempo (CAS 2564-83-2) is a stable nitroxide radical widely employed in biomedical research for its redox-active properties It facilitates the dismutation of superoxide radicals thereby modulating mitochondrial reactive oxygen species (ROS) levels and influencing cellular oxidative stress responses Tempo also serves as an oxidation catalyst particularly in the transformation of primary alcohols to aldehydes Studies indicate that Tempo exerts both antioxidant and mutagenic effects inducing DNA strand breaks and displaying cytotoxic and mutagenic activities in in vitro models such as murine lymphoma cells It is utilized for investigating oxidative stress redox regulation and chemical mutagenesis
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eMolecules Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 50mg 272386939 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 50mg 272386939 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
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Aobchem 1, 2, 3, 4-Tetrahydro-7-nitroquinoline, AOBCHEM USA 28090-25G. 30450-62-5. MFCD00496654
1, 2, 3, 4-Tetrahydro-7-nitroquinoline, AOBCHEM USA 28090-25G. 30450-62-5. MFCD00496654
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Apexbio Technology LLC CP 339818 hydrochloride 10mg
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CP 339818 hydrochloride (CAS 478341-55-8) is a small-molecule antagonist targeting the Kv1 3 potassium channel It is designed to selectively inhibit Kv1 3-mediated ion conductance thereby modulating T-cell activation CP 339818 hydrochloride exerts its biological activity primarily through stabilization of the Kv1 3 channel s C-type inactivation state In in vitro studies CP 339818 hydrochloride demonstrates potent inhibition of Kv1 3 channels with an IC50 value of approximately 200 nM Based on these pharmacological properties CP 339818 hydrochloride holds research potential in the investigation of immune modulation mechanisms relevant to autoimmune and inflammatory disorders
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Medchemexpress LLC CP 339818 hydrochloride | 478341-55-8 | 99.6% | 340.89 | 1 ML
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CP 339818 hydrochloride is a non-peptide blocker of Kv1.3 (IC50 = 200 nM) and Kv1.4 channels. It also inhibits HCN channels with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-), respectively. The compound exhibits significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. It selectively blocks Kv1.3, which in turn inhibits the activation process of human T cells. CP 339818 hydrochloride can be utilized for studying the physiological functions of HCN and Kv channels. For research use only, not for sale to patients.
- Non-peptide blocker of Kv1.3 and Kv1.4 channels.
- Inhibits HCN1 and HCN4 channels.
- Selectively blocks Kv1.3, inhibiting human T-cell activation.
- Useful for studying physiological functions of HCN and Kv channels.
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Apexbio Technology LLC CP 339818 hydrochloride 50mg
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CP 339818 hydrochloride (CAS 478341-55-8) is a small-molecule antagonist targeting the Kv1 3 potassium channel It is designed to selectively inhibit Kv1 3-mediated ion conductance thereby modulating T-cell activation CP 339818 hydrochloride exerts its biological activity primarily through stabilization of the Kv1 3 channel s C-type inactivation state In in vitro studies CP 339818 hydrochloride demonstrates potent inhibition of Kv1 3 channels with an IC50 value of approximately 200 nM Based on these pharmacological properties CP 339818 hydrochloride holds research potential in the investigation of immune modulation mechanisms relevant to autoimmune and inflammatory disorders
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TARGETMOL CHEMICALS INC Mefloquine 1MG
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Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 uM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research. Purity 99.97%
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TARGETMOL CHEMICALS INC Quinine dihydrochloride 500MG
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Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal). Purity 99.45%
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Medchemexpress LLC Mefloquine | 53230-10-7 | 99.96% | 378.31 | 50 MG
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Mefloquine (Standard) is the analytical standard of Mefloquine, intended for research and analytical applications. It is an orally active and potent quinoline antimalarial agent and an anti-SARS-CoV-2 entry inhibitor. Mefloquine also acts as a K+ channel (KvQT1/minK) antagonist with an IC50 of approximately 1 μM. It can be utilized for malaria, systemic lupus erythematosus, and cancer research.
- Analytical standard of Mefloquine.
- Intended for research and analytical applications.
- Orally active and potent quinoline antimalarial agent.
- Anti-SARS-CoV-2 entry inhibitor.
- K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM.
- Applicable for malaria, systemic lupus erythematosus, and cancer research.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
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Medchemexpress LLC Mefloquine (hydrochloride) | 51773-92-3 | 99.98% | 414.77 | 500 MG
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Mefloquine hydrochloride is a quinoline antimalarial agent and an anti-SARS-CoV-2 entry inhibitor. It acts as a K+ channel antagonist and is suitable for research in malaria, systemic lupus erythematosus, and cancer. It selectively inhibits prostate cancer cell growth and shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine. Animal studies indicate it can reverse lower vertebral cancellous bone volume.
- Quinoline antimalarial agent
- Anti-SARS-CoV-2 entry inhibitor
- K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM
- Selectively inhibits prostate cancer cell growth with an IC50 of ~10 μM
- Induces hyperpolarization of mitochondrial membrane potential (MMP) and ROS generation
- Shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine
- Can be used for malaria, systemic lupus erythematosus and cancer research
- Reverses lower vertebral cancellous bone volume and bone formation in old mice
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Medchemexpress LLC Mefloquine (Standard) | 53230-10-7 | MFCD00869324 | 378.31 | 100 MG
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Mefloquine (Standard) is the analytical standard of Mefloquine, intended for research and analytical applications. It is an orally active and potent quinoline antimalarial agent and an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. This analytical standard grade compound is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Orally active and potent quinoline antimalarial agent.
- Anti-SARS-CoV-2 entry inhibitor.
- K+ channel (KvQT1/minK) antagonist.
- Used for malaria, systemic lupus erythematosus, and cancer research.
- Analytical standard grade for qualitative, quantitative, and methodological research experiments.
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Medchemexpress LLC Quinidine hydrochloride monohydrate | 6151-40-2 | 99.97% | 100 MG
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Quinidine hydrochloride monohydrate is an anti-arrhythmic agent that also acts as a potent blocker of K+ channels. It is intended for research use only.
- Potent K+ channel blocker.
- Aids in electrophysiological research.
- Available in solid and solution forms for various experimental needs.
- Comes with detailed documentation for quality assurance.
- Referenced in numerous scientific publications.
- Offers diverse applications for in vitro and in vivo studies.
- Easily soluble in common laboratory solvents.
- Supports accurate dosage calculations for experimental protocols.
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Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.36% | 5 G
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Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine also acts as a K+ channel blocker with an IC50 of 19.9 μM, and it can induce apoptosis. It can be used for malaria research.
- Antiarrhythmic agent: Helps in the treatment of irregular heartbeats.
- Potent, orally active, selective cytochrome P450db inhibitor: Targets and inhibits specific cytochrome P450 enzymes.
- K+ channel blocker: Blocks potassium channels with an IC50 of 19.9 μM.
- Induces apoptosis: Capable of triggering programmed cell death.
- Used for malaria research: Applicable in studies related to malaria.
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Medchemexpress LLC Cinchonidine (α-Quinidine) | 485-71-2 | 99.6% | 294.39 | 100 G
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Cinchonidine (α-Quinidine) is a cinchona alkaloid found in *Cinchona officinalis* and *Gongronema latifolium*. It is a building block used in asymmetric synthesis in organic chemistry. It acts as a weak inhibitor of the serotonin transporter (SERT) and exhibits antimalarial activities.
- Derived from *Cinchona officinalis* and *Gongronema latifolium*
- Used as a building block in asymmetric synthesis
- Weak inhibitor of the serotonin transporter (SERT)
- Exhibits antimalarial activities
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Selleck Chemical LLC Quinidine hydrochloride monohydrate S4681-1g
Quinidine hydrochloride monohydrate is an anti-arrythmic agent and a potent potassium channel inhibitor with IC50 of 19 9 M
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