Choose the brand aligned with your industry so we can best serve your needs.
For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
ML324 (CAS 1222800-79-4) is a small-molecule inhibitor targeting JMJD2 histone demethylase enzymes It is designed to suppress JMJD2-mediated demethylation of histone H3 lysine 9 (H3K9) thereby affecting gene transcription regulation ML324 exerts its biological activity primarily through inhibition of JMJD2 demethylases In cell-based studies ML324 inhibits JMJD2 activity displaying an IC50 value of 920 nM In experimental models including HFF and MRC-5 cell lines it blocks immediate-early (IE) gene expression of HSV and hCMV reduces viral spread and plaque formation and inhibits HSV-1 reactivation and replication in latent infection models such as mouse neuronal ganglia explants Based on these pharmacological properties ML324 holds research potential in chromatin remodeling and antiviral therapeutic strategies
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More