Quinolines and derivatives
Ethyl 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylate 98.0+%, TCI America™
CAS: 112811-71-9 Molecular Formula: C16H15F2NO4 Molecular Weight (g/mol): 323.296 MDL Number: MFCD05864419 InChI Key: XPAOPAPDCRLMTR-UHFFFAOYSA-N Synonym: 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester PubChem CID: 10758239 IUPAC Name: ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxoquinoline-3-carboxylate SMILES: CCOC(=O)C1=CN(C2=C(C(=C(C=C2C1=O)F)F)OC)C3CC3
Apexbio Technology LLC ML385(Synonyms: ML-385, NRF2 inhibitor ML385, ML385 NRF2 inhibitor, ML385 inhibitor, NRF2-IN-1, NRF2-IN1), 200mg, CAS: 846557-71-9.
ML385 (CAS 846557-71-9) is a selective inhibitor of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) displaying an IC50 of 1 9 M NRF2 regulates cellular antioxidant responses detoxification pathways and multidrug transporters and its activation is frequently implicated in therapeutic resistance of non-small cell lung cancer (NSCLC) In A549 cells ML385 treatment reduces expression of NRF2-dependent genes dose- and time-dependently Additionally in NSCLC mouse models ML385 treatment diminished tumor growth and metastasis especially when combined with carboplatin underscoring its utility in cancer research and potential therapeutic exploration
Apexbio Technology LLC WAY-100635 162760-96-5 200mg
WAY-100635 (CAS 162760-96-5) is a highly selective antagonist of the serotonin 5-HT1A receptor In vitro studies show that WAY-100635 displaces the 5-HT1A radioligand [3H]8-OH-DPAT from rat hippocampal membranes with a pIC50 of 8 87 and acts as a potent antagonist in functional assays without agonist or partial agonist activity In ex vivo guinea pig ileum assays it effectively blocks 5-carboxamidotryptamine-induced 5-HT1A responses (pA2 9 71 at 0 3 nM) In vivo WAY-100635 counteracts 8-OH-DPAT-induced behavioral and thermoregulatory effects in rodents at subcutaneous doses as low as 0 003 0 01 mg/kg It is widely utilized in neuropharmacological research and neuroimaging as a SPECT/PET ligand to investigate 5-HT1A receptor function in psychiatric and neurological disorders