Quinolines and derivatives
Apexbio Technology LLC Kobe0065 436133-68-5 200mg
Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms
Medchemexpress LLC Amifostine (trihydrate) | 112901-68-5 | 100.0% | 200 MG
Amifostine trihydrate is a broad-spectrum cytoprotective agent and radioprotector. It selectively protects normal tissues from damage caused by radiation and chemotherapy. It acts as a potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer, protecting cells by scavenging oxygen-derived free radicals. It also reduces renal toxicity and exhibits antiangiogenic action.
- Broad-spectrum cytoprotective agent
- Radioprotector
- Selectively protects normal tissues from radiation and chemotherapy damage
- Potent HIF-α1 and p53 inducer
- Scavenges oxygen-derived free radicals
- Reduces renal toxicity
- Exhibits antiangiogenic action
- Protects against tert-Butyl hydroperoxide (TBHP)-induced cell damage
- Reduces H9c2 cell apoptosis
- Provides protection against myocardial ischemia/reperfusion injury
Medchemexpress LLC 2'-Azido-2'-deoxycytidine | 51034-68-5 | MFCD00043047 | C9H12N6O4 | 200 MG
2'-Azido-2'-deoxycytidine is a purine nucleoside analogue with broad antitumor activity, especially against indolent lymphoid malignancies. Its anticancer mechanisms include inhibiting DNA synthesis and inducing apoptosis. It also functions as a click chemistry reagent, capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This azidonucleoside requires diphosphorylation to inhibit nucleotide reductase.
- Broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis and induces apoptosis
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Requires diphosphorylation for nucleotide reductase inhibition
eMolecules AstaTech / 2-(BROMOMETHYL)-13-DIFLUORO-5-METHOXYBENZENE / 0.25g / 277524471 / 90964 / 95.000 / 94278-68-9 / MFCD04115925 / 237.044 / C8H7BrF2O
AstaTech / 2-(BROMOMETHYL)-13-DIFLUORO-5-METHOXYBENZENE / 0.25g / 277524471 / 90964 / 95.000 / 94278-68-9 / MFCD04115925 / 237.044 / C8H7BrF2O