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Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1

Apexbio Technology LLC LY2608204 1234703-40-2 200mg
SDP

LY2608204 (CAS 1234703-40-2) is a small molecule activator of glucokinase (GK) enhancing its activity as indicated by an EC50 of 42 nM under low glucose conditions In the INS1-E rat insulinoma cell line LY2608204 stimulates glucose metabolism with an EC50 of 579 nM Preclinical studies have demonstrated that administration of LY2608204 leads to dose-dependent reductions in both fasting and postprandial blood glucose levels These properties make LY2608204 a valuable tool for investigating GK modulation and its effects on glucose homeostasis in metabolic disease research

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2

Medchemexpress LLC Quinidine hydrochloride monohydrate | 6151-40-2 | 99.97% | 100 MG
SDP

Quinidine hydrochloride monohydrate is an anti-arrhythmic agent that also acts as a potent blocker of K+ channels. It is intended for research use only.

  • Potent K+ channel blocker.
  • Aids in electrophysiological research.
  • Available in solid and solution forms for various experimental needs.
  • Comes with detailed documentation for quality assurance.
  • Referenced in numerous scientific publications.
  • Offers diverse applications for in vitro and in vivo studies.
  • Easily soluble in common laboratory solvents.
  • Supports accurate dosage calculations for experimental protocols.

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3

eMolecules​ 3-AMINOISOQUINOLINE-8-CARBOXYLIC ACID HCL | 1337882-40-2 | MFCD28291832 | 1g

AstaTech | 3-AMINOISOQUINOLINE-8-CARBOXYLIC ACID HCL | 1g | 200614905 | 68507 | 95.000 | 1337882-40-2 | MFCD28291832 | 224.640 | C10H9ClN2O2

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4

eMolecules​ ChemScene / 5-Bromo-4-ethylpyridin-2-amine / 100mg / 784458588 / CS-0334320 / 0.000 / 1368352-40-2 / MFCD22058625 / 201.067 / C7H9BrN2

ChemScene / 5-Bromo-4-ethylpyridin-2-amine / 100mg / 784458588 / CS-0334320 / 0.000 / 1368352-40-2 / MFCD22058625 / 201.067 / C7H9BrN2

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5

Medchemexpress LLC Anthra[1,9-cd]pyrazol-6(2H)-one | 129-56-6 | 99.7% | 200 MG
SDP

SP600125 is a reversible, ATP-competitive inhibitor of c-Jun N-terminal kinases (JNK1, JNK2, JNK3) used as a research reagent. Reported IC50 values are 40 nM for JNK1, 40 nM for JNK2, and 90 nM for JNK3. The compound has also been reported to inhibit ferroptosis and to induce conversion from autophagy to apoptosis in certain cancer cells.

  • ATP-competitive inhibitor of JNK1, JNK2, and JNK3.
  • IC50 values: 40 nM (JNK1), 40 nM (JNK2), 90 nM (JNK3).
  • High purity (99.73%).
  • Available as a 200 MG pack for research and analytical use.
  • Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
  • Intended for research use only.

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6

Apexbio Technology LLC SCH 527123 473727-83-2 200mg
SDP

SCH 527123 (CAS 473727-83-2) is a selective antagonist of chemokine receptor 2 (CXCR2) It inhibits CXCR2-mediated signaling pathways by reducing phosphorylation events within the NF- B MAPK and AKT signaling cascades In colorectal cancer cell lines SCH 527123 suppresses cell growth in a dose-dependent manner with reported IC50 values ranging from approximately 18 to 40 mol/L after a 72-hour treatment Elevated IL-8 expression in cell lines such as HCT116 and Caco2 correlates with decreased sensitivity to SCH 527123 This compound is utilized in research investigating CXCR2 signaling in inflammation and tumor growth

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7

Apexbio Technology LLC Fluvastatin Sodium 93957-55-2 200mg
SDP

Fluvastatin Sodium (CAS 93957-55-2) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme in cholesterol biosynthesis By blocking HMG-CoA reductase activity fluvastatin reduces serum total cholesterol LDL-cholesterol and apolipoprotein B while increasing HDL-cholesterol and apolipoprotein A-I levels In research settings fluvastatin exhibits anti-atherosclerotic anti-thrombotic and antioxidant properties Studies have shown fluvastatin decreases platelet aggregation dose-dependently in vitro reducing platelet aggregation by approximately 10-15% at clinical doses (40 mg/day) Additionally fluvastatin inhibits inflammatory angiogenesis and NO production suggesting potential applications in inflammatory and cardiovascular research

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