Quinolines and derivatives
Medchemexpress LLC Chlormethiazole hydrochloride | 6001-74-7 | MFCD00673948 | 99.9% | C6H9Cl2NS | 200 MG
Chlormethiazole hydrochloride is a potent and orally active GABAA agonist, known for its ability to inhibit cytochrome P450 isoforms CYP2A6 and CYP2E1 in human liver microsomes. This compound acts as an anticonvulsant agent, showing potential for the treatment of convulsive status epilepticus. It is provided as a light yellow to yellow solid.
- Potent and orally active GABAA agonist
- Inhibits cytochrome P450 isoforms CYP2A6 and CYP2E1
- Anticonvulsant agent
- Soluble in DMSO and H2O
Apexbio Technology LLC Fasudil (HA-1077) HCl 105628-07-7 200mg
Fasudil HA-1077 HCl (CAS 105628-07-7) is a small-molecule inhibitor targeting Rho-associated protein kinase (ROCK) a serine/threonine kinase It is designed to inhibit ROCK thereby regulating cellular processes such as proliferation migration and apoptosis Fasudil HA-1077 HCl exerts its biological activity primarily through ROCK inhibition In cell-based studies Fasudil inhibits proliferation and migration and promotes apoptosis in cancer cell models including bladder carcinoma (5637 UM-UC-3) and oral squamous cell carcinoma (SCC-4) its ROCK inhibitory activity shows an IC50 value of approximately 0 74 M Based on these pharmacological properties Fasudil HA-1077 HCl holds research potential in oncology and disease models involving ROCK-mediated signaling