Tetrahydroisoquinolines
Medchemexpress LLC Nampt-IN-3 | 2121591-52-2 | 99.0% | 503.55 | 1 ML
Nampt-IN-3 (Compound 35) is a small molecule inhibitor that simultaneously targets nicotinamide phosphoribosyltransferase (NAMPT) and HDAC, with IC50 values of 31 nM and 55 nM, respectively. It is effective in inducing cell apoptosis and autophagy, ultimately leading to cell death.
- Simultaneously inhibits NAMPT and HDAC.
- Induces cell apoptosis.
- Induces autophagy.
- Leads to cell death.
- Demonstrates cytotoxicity in HCT-116, HepG2, and MDA-MB-231 cell lines.
- Available in various quantities for research use.
Medchemexpress LLC Nampt-IN-3 | 2121591-52-2 | 99.0% | 503.55 | 100 MG
Nampt-IN-3 (Compound 35) simultaneously inhibits nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. It effectively induces cell apoptosis and autophagy, leading to cell death.
- Inhibits nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM.
- Effectively induces cell apoptosis and autophagy.
- Leads to cell death.
- Demonstrates cytotoxicity in human HCT116 cells with an IC50 of 2.4 μM.
- Demonstrates cytotoxicity in human HepG2 cells with an IC50 of 4.5 μM.
- Demonstrates cytotoxicity in human MDA-MB-231 cells with an IC50 of 10 μM.
Medchemexpress LLC Nampt-IN-3 | 2121591-52-2 | 99.0% | 503.55 | 10 MG
Nampt-IN-3 (Compound 35) is an agent that simultaneously inhibits nicotinamide phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) with IC50 values of 31 nM and 55 nM, respectively. It effectively induces cell apoptosis and autophagy, ultimately leading to cell death. This product is intended for research use only and is not sold to patients. It appears as a white to off-white solid.
- Simultaneously inhibits NAMPT and HDAC.
- Induces cell apoptosis and autophagy.
- Leads to cell death.
- High purity of 98.97%.
- Available in both solid and pre-dissolved solution forms for convenience.
- Used in research for cytotoxicity studies in various cell lines such as HCT-116, HepG2, and MDA-MB-231.
Medchemexpress LLC Diperdipine | 108852-42-2 | 457.52 | 10 MG
YS-201 (Diperdipine) is a dihydropyridine-type calcium channel antagonist that targets calcium channels. It is involved in membrane transporter/ion channel and neuronal signaling pathways and has potential for angina pectoris and hypertension treatment.
- Functions by blocking calcium channels.
- Markedly reduces systemic vascular resistance.
- Improves stroke index and left ventricular ejection fraction.
- Leads to an augmented left ventricular end-diastolic volume index, indicating an increase in preload.
- Has an absolute bioavailability of 18.7% after intravenous and oral doses.
- Applicable in the treatment of angina pectoris and hypertension.