Tetrapyrroles and derivatives
Abcam Necrostatin-1, necroptosis inhibitor, 5MG
MW 259.33 Da, Purity >99%. Potent, specific necroptosis inhibitor (EC₅₀ = 490 nM). Selective allosteric inhibitor of death domain receptor-associated adaptor kinase RIP1 in vitro (EC₅₀ = 182 nM). Caspase independent, programmed necrosis pathway.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LY 294002, PI3-kinase inhibitor, 1MG
MW 307.3 Da, Purity >99%. A highly selective inhibitor of phosphatidylinositol 3-kinase (IC₅₀ = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC₅₀ > 50 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam WAY-100635 maleate, 5-HT1A receptor antagonist, 50MG
MW 538.6 Da, Purity >98%. Potent, selective, silent 5-HT1A receptor antagonist (IC50 = 1.35 nM). Displays >100-fold selectivity for 5-HT1Arelative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels. Binds selectively to rodent brain 5-HT1A receptors *in vivo* (iv admin). Unlike WAY100135, WAY100635 displays no partial agonist activity in the ventral hippocampus of rats.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AMD3100 octahydrochloride, C x CR4 antagonist, 50MG
MW 794.5 Da, Purity >99%. Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF-1 (CXCL12). It suppresses infection by HIV with an IC₅₀ value of 1-10 ng/ml with selectivity toward CXCR4-tropic virus. Plerixafor mobilizes hematopoietic stem and progenitor cells for transplant better than G-CSF alone. It also increases T-cell trafficking in the blood and spleen as well as the central nervous system. Plerixafor regulates the growth of primary and metastic breast cancer cells and inhibits dissemination of ovarian carcinoma cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 203580, p38 MAPK inhibitor, 10MG
MW 377.4 Da, Purity >99%. SB 203580, p38 MAPK inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam IBM x , Non-specific cAMP and cGMP inhibitor, 1G
MW 222.24 Da, Purity >98%. Non-specific cAMP and cGMP inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam x anomeline o x alate, M1 muscarinic acetylcholine receptor agonist, 50MG
MW 371.5 Da, Purity >99%. Functionally preferring M₁ muscarinic acetylcholine receptor agonist (pKi values are 7.1 (M₁), 6.9 (M₂), 7.4 (M₃), 7.7 (M₄) and 7.4 (M₅)). Able to cross blood-brain barrier. Displays antipsychotic activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam beta-Amyloid Peptide (1-40) (human), 1MG
MW 4330 Da. beta-Amyloid Peptide (1-40) (human). Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 50MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical N-methyl Protoporphyrin IX, Purity: ≥95% (a mixture of isomers), CAS: 79236-56-9, 1 mg
A transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway
Sigma Aldrich Fine Chemicals Biosciences 5,10,15,20-Tetraphenyl-21H,23H-porphine >=99% | 917-23-7 | MFCD00011680 | 1G
5,10,15,20-Tetraphenyl-21H,23H-porphine >=99% | Purity: >=99% | Mol Wt: 614.74 | 917-23-7 | MFCD00011680 | 1G
Sigma Aldrich Fine Chemicals Biosciences Hemin | 16009-13-5 | MFCD00010726 | 1g
Hemin | Purity: 90% | Mol Wt: 651.94 | 16009-13-5 | MFCD00010726 | 1g
Sigma Aldrich Fine Chemicals Biosciences 5,10,15,20-Tetraphenyl-21H,23H-porphine 97% | 917-23-7 | MFCD00011680 | 1G
5,10,15,20-Tetraphenyl-21H,23H-porphine 97% | Purity: 97% | Mol Wt: 614.74 | 917-23-7 | MFCD00011680 | 1G