Tetrapyrroles and derivatives

STEMCELL Technologies Methylcobalamin, Size: 100 mg

Methylcobalamin is a vitamin B12 analog and a coenzyme involved in homocysteine metabolism (Okada et al.). Methylcobalamin elevates the activities of ERK1/2 and AKT and improves nerve regeneration in rats (Okada et al.). This small molecule has therapeutic potential for treating nervous disorders (Okada et al.).DIFFERENTIATION· Promotes Schwann cell differentiation in vitro (Nishimoto et al.).DISEASE MODELING· Promotes neuronal survival in rats (Okada et al.).

Abcam Rhodadyn™ B10, Negative control for Rhodadyn™ C10, 5MG

MW 322.44 g/mol, Purity >98%. Negative control for Rhodadyn™ C10 (ab120795). Demonstrates no significant inhibition of dynamin I or dynamin II in vitro GTPase activity at concentrations up to 300 μM and has no effect on clathrin-mediated endocytosis of transferrin when applied for 30 minutes to U2OS cells in culture. Robertson J et al. The rhodadyn™ a new class of small molecule inhibitors of dynamin GTPase. ACS Med. Chem (2012).

The product is subject to the following: Abcam Restricted Use Statement

Cayman Chemical MethylcobalamIn 250mg

An analog of vitamin B12 with diverse neurological activities; promotes neurite outgrowth and survival in primary CGN and DRG cells and activation of ERK1/2 and Akt from 0.1-100 µM; improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury at 1 mg/kg per day; decreases the number of atypical mitochondria in the sciatic nerve and reduces vincristine-induced mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain; reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of ALS; enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer

Cayman Chemical MethylcobalamIn 1g

An analog of vitamin B12 with diverse neurological activities; promotes neurite outgrowth and survival in primary CGN and DRG cells and activation of ERK1/2 and Akt from 0.1-100 µM; improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury at 1 mg/kg per day; decreases the number of atypical mitochondria in the sciatic nerve and reduces vincristine-induced mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain; reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of ALS; enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer

Cayman Chemical MethylcobalamIn 500mg

An analog of vitamin B12 with diverse neurological activities; promotes neurite outgrowth and survival in primary CGN and DRG cells and activation of ERK1/2 and Akt from 0.1-100 µM; improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury at 1 mg/kg per day; decreases the number of atypical mitochondria in the sciatic nerve and reduces vincristine-induced mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain; reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of ALS; enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer

Cayman Chemical MethylcobalamIn 100mg

An analog of vitamin B12 with diverse neurological activities; promotes neurite outgrowth and survival in primary CGN and DRG cells and activation of ERK1/2 and Akt from 0.1-100 µM; improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury at 1 mg/kg per day; decreases the number of atypical mitochondria in the sciatic nerve and reduces vincristine-induced mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain; reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of ALS; enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer