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A long chain saturated, fatty acid; the methyl ester of the 25-carbon, fully saturated fatty acid pentacosanoic acid; designed to be used as a standard in total fatty acid analysis
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AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It exerts its inhibitory effects on PRMTs by blocking peptide-substrate binding.
Potent, cell-permeable, and reversible inhibitor of PRMTs.
Inhibits type I PRMTs and type II PRMT5.
Specifically inhibits arginine methyltransferase activity, not lysine, and does not compete for the AdoMet binding site.
Inhibits methylation of GFP-Npl3 and cellular proteins.
Inhibits the cell viability of sarcoma in S180 and U2OS cells in a time- and dose-dependent manner in vitro.
Reduces S180 cell viability through the induction of cell apoptosis.
Inhibits S180 viability in vivo.
Downregulates PRMT5 and decreases levels of H4R3me2s and H3R8me2s in a tumor xenograft model.
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AMI-1 is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It inhibits PRMTs by blocking peptide-substrate binding.
Potent, cell-permeable, and reversible inhibitor
Inhibits in vitro methylation reactions performed by PRMT1, -3, -4, -6, and Hmt1p
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N-Carbobenzyloxy-amino-L-alanine is an alanine derivative. Amino acids and their derivatives are used commercially as ergogenic supplements, influencing various physiological activities. This compound offers beneficial properties as an ergogenic dietary substance.
Alanine derivative
Used as an ergogenic supplement
Influences secretion of anabolic hormones
Enhances fuel supply during exercise
Improves mental performance under stress
Prevents exercise-induced muscle damage
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