Arylhydroxamates
Medchemexpress LLC Indirubin-3'-oxime | 667463-82-3 | 99.1% | 277.28 | 100 MG
Indirubin-3'-oxime (IDR3O) is a synthetic derivative of indirubin, acting as a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). It directly inhibits all three isoforms of JNK (JNK1, JNK2, and JNK3). This product can enhance height growth by activating Wnt/β-catenin signaling in chondrocytes and prevents cerebellar granule neurons from apoptosis.
- Inhibitor of cyclin-dependent kinases (CDKs)
- Inhibits glycogen synthase kinase 3β (GSK3β)
- Directly inhibits JNK1, JNK2, and JNK3 isoforms
- Enhances height growth via activation of Wnt/β-catenin signaling
- Blocks c-Jun phosphorylation induced by potassium withdrawal
- Prevents cerebellar granule neurons from apoptosis
- Significantly prevents 6OHDA-induced decrease of nuclear localized MEF2D expression
Medchemexpress LLC Indirubin-3′-oxime | 667463-82-3 | 99.1% | C16H11N3O2 | 10MG
Indirubin-3′-oxime is a synthetic indirubin derivative used as a research reagent that potently inhibits cyclin-dependent kinases (CDKs), GSK3β, and JNK. Supplied as a brown-red solid with reported purity of 99.1%, it is intended for biochemical kinase assays, cell-based studies, and in vivo formulations; soluble in DMSO and available in multiple milligram sizes. CAS 667463-82-3.
- Potent kinase inhibitor of CDKs, GSK3β, and JNK.
- High purity (99.1%) suitable for research applications.
- Available as solid powder and ready-to-use DMSO solutions.
- Soluble in DMSO at high concentration (approximately 100 mg/mL).
- Storage conditions support long-term stability at -20°C for powder.
- Provided with datasheet, certificate of analysis, and safety data sheet for quality and handling.
Medchemexpress LLC Indirubin-3′-oxime | 667463-82-3 | 99.1% | 277.28 | 50 MG
Indirubin-3′-oxime (IDR3O) is a synthetic derivative of indirubin. It is a potent inhibitor of cyclin-dependent kinases (CDKs), glycogen synthase kinase 3β (GSK3β), and all three isoforms of JNK (JNK1, JNK2, JNK3). Studies show it enhances height growth by activating Wnt/β-catenin signaling in chondrocytes and prevents apoptosis in cerebellar granule neurons.
- Potent inhibitor of cyclin-dependent kinases (CDKs)
- Inhibits glycogen synthase kinase 3β (GSK3β)
- Directly inhibits JNK1, JNK2, and JNK3
- Enhances height growth by activating Wnt/β-catenin signaling in chondrocytes
- Prevents c-Jun phosphorylation in cerebellar granule neurons
- Prevents 6OHDA-induced decreases in nuclear localized MEF2D expression in PC12 cells
- Enhances tibial longitudinal growth in mice
Medchemexpress LLC Indirubin-3′-oxime | 667463-82-3 | MFCD02683594 | 99.1% | 277.28 g·mol⁻¹ | C16H11N3O2 | 5 MG
Indirubin-3′-oxime (IDR3O) is a synthetic derivative of indirubin used as a research reagent to modulate kinase signaling. It inhibits cyclin-dependent kinases, glycogen synthase kinase 3β, and c-Jun N-terminal kinases, and is used in biochemical, cell-based, and in vivo research. The compound is supplied as a brown to red solid with high reported purity and recommended storage conditions for powder and solutions.
- Potent inhibitor of CDKs, GSK-3β, and JNK isoforms.
- Reported enzyme IC50s in the low micromolar range for JNK1, JNK2, and JNK3.
- High reported purity suitable for biochemical and cell-based assays.
- Soluble in DMSO at high concentration; in vivo formulations documented by the supplier.
- Powder stable at -20°C for years; store solutions at -80°C for long term.