Carboximidamides
Medchemexpress LLC Melagatran | 159776-70-2 | 99.3% | 10 MG
Melagatran is a reversible, selective, orally active direct inhibitor of thrombin with a Ki of 2 nM. It directly binds to the active site of thrombin, inhibiting the thrombin-mediated conversion of fibrinogen to fibrin. Melagatran reduces the DNA binding activity of NF-κB and AP-1, and has shown to reduce fibrin deposition in organs, alleviate ischemic brain damage, and reduce the size of advanced atherosclerotic lesions.
- Reversible, selective thrombin inhibitor
- Inhibits thrombin-mediated fibrinogen to fibrin conversion
- Reduces DNA binding activity of NF-κB and AP-1
- Alleviates ischemic brain damage
- Decreases advanced atherosclerotic lesion size
- Used in cardiovascular disease research
- Investigated for neurological disease studies
Medchemexpress LLC Smap-2 (DT-1154) | 1809068-70-9 | 99.5% | 10 MG
SMAP-2 (DT-1154) is an orally active small-molecule activator of protein phosphatase 2A (PP2A) that exhibits anti-cancer activity in cell and animal models, reducing viability of pancreatic ductal adenocarcinoma cell lines and demonstrating in vivo efficacy.
- Orally active PP2A activator with demonstrated anti-cancer activity.
- High purity (99.5%).
- Molecular weight 532.57 g/mol; formula C27H27F3N2O4S.
- High solubility in DMSO (300 mg/mL) and formulatable for in vivo dosing using recommended protocols.
- Stable as a powder when stored at -20°C and 4°C for indicated durations.
- For research use only; not for human use.
STA PHARMACEUTICAL US LLC ANA 2'-F U amidite | 10 g | CAS 1190089-70-3 | MDL MFCD15145421
ANA 2'-F U amidite is a Amidite reagent (Subcategory: ANA Series) sold by WuXi TIDES. Offered in 10 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 1190089-70-3
- MDL: MFCD15145421
- InChIKey: HQHQPAYRJJMYQX-CPBIVIIKSA-N
- Molecular Weight: 748.789165161
- Molecular Formula: C39H46FN4O8P
- Purity: ≥98%
- Container Type: 250 mL Glass (28-400)
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 179.7 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(NC(C=C5)=O)=O)F)OCCC#N)C(C)C)C
STA PHARMACEUTICAL US LLC ANA 2'-F U amidite | 10 g | CAS 1190089-70-3 | MDL MFCD15145421
ANA 2'-F U amidite is a Amidite reagent (Subcategory: ANA Series) sold by WuXi TIDES. Offered in 10 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 1190089-70-3
- MDL: MFCD15145421
- InChIKey: HQHQPAYRJJMYQX-CPBIVIIKSA-N
- Molecular Weight: 748.789165161
- Molecular Formula: C39H46FN4O8P
- Purity: ≥98%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(NC(C=C5)=O)=O)F)OCCC#N)C(C)C)C
![Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230936.png-250.jpg)
Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 10 MG
Darigabat is a subtype-selective GABAA positive allosteric modulator used for preclinical research into epilepsy, anxiety, and seizure disorders. It is a small-molecule research compound with confirmed chemical identity and supplier-stated purity.
- CAS number 1614245-70-3.
- Chemical formula C22H21FN4O3S.
- Molecular weight 440.49 g/mol.
- Purity 99.3% (supplier listing).
- Packaging 10 MG; solid storage 4°C, protect from light; in solvent -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or veterinary use.
TARGETMOL CHEMICALS INC N-p-Tosyl-GPR-pNA acetate 25MG
Also available in 1 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. N-(p-Tosyl)-GPR-pNA acetate is a colorimetric substrate for thrombin that can act as a measure of thrombin activity.
Medchemexpress LLC Pentagamavunon-1 (PGV-1) | 27060-70-4 | 98.95% | 348.43 | 100 MG
Pentagamavunon-1 (PGV-1) is a Curcumin analog with oral activity. It targets multiple molecular mechanisms to induce apoptosis, including the inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 also inhibits NF-κB activation.
- Enhances the cytotoxic effect of 5-FU on WiDr cells
- Induces G2/M arrest
- Exhibits significant anti-tumor activity in a PDX model
- Shows minimal adverse effects on normal cells
- Soluble in DMSO for in vitro studies
- Soluble in 10% DMSO and 90% (20% SBE-β-CD in saline) for in vivo studies
- Soluble in 10% DMSO and 90% corn oil for in vivo studies
TARGETMOL CHEMICALS INC CP 461 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. CP 461 (UNII-68OJX9I7DT) a specific PDE2A inhibitor is a novel pro-apoptotic compound that inhibits cyclic GMP phosphodiesterase but not cyclooxygenase-1 or -2. CP 461 inhibits the growth of a variety of human tumor cell lines in vitro and selectively induces apoptosis in cancer cell lines but not in normal cells. purity: 99%
Medchemexpress LLC Ask1-in-2 | 2541792-70-3 | MFCD11217007 | 99.6% | C19H17FN6O | 10MG
ASK1-IN-2 is a small-molecule, orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with a reported biochemical IC50 of 32.8 nM. Supplied as a high-purity research chemical (CAS 2541792-70-3; formula C19H17FN6O), it is available as a solid powder and as a 10 mM solution in DMSO for use in in vitro and in vivo preclinical studies, including research into inflammatory conditions such as ulcerative colitis.
- Potent ASK1 inhibition (IC50 32.8 nM).
- Orally active small molecule suitable for in vivo studies.
- High purity (99.6%).
- Available as solid powder and as 10 mM solution in DMSO.
- Suitable for research into inflammatory diseases such as ulcerative colitis.
- Provided with safety data sheet and product documentation.
Medchemexpress LLC Atx inhibitor 1 | 2225892-70-4 | 99.3% | 501.30 g/mol | C21H23Cl2N2O6P | 5 MG
ATX inhibitor 1 is a potent autotaxin (ATX) inhibitor with nanomolar activity (IC50 = 1.23 nM by FS-3 assay; 2.18 nM by bis-pNPP). It is supplied as a solid research compound for in vitro and preclinical research use only.
- Potent autotaxin inhibitor with nanomolar IC50 values (1.23 nM FS-3; 2.18 nM bis-pNPP).
- Molecular formula: C21H23Cl2N2O6P.
- Molecular weight: 501.30 g/mol.
- Purity: 99.3% by HPLC.
- Physical form: solid powder.
- Storage: powder -20°C for 3 years or 4°C for 2 years; in solvent -80°C for 6 months.
- Available sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, or 10 mM in DMSO solutions.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Fluorizoline 10mg | 1362243-70-6 | 10 MG
Fluorizoline is a small-molecule research compound that induces apoptosis by selectively binding prohibitin proteins (PHB1 and PHB2) and upregulating pro-apoptotic factors such as NOXA and BIM. It is supplied as a high-purity solid and as a DMSO solution for use in in vitro cellular and biochemical studies.
- Induces apoptosis via prohibitin 1 and 2 binding.
- High purity (99.77%).
- Available in small solid quantities and as a 10 mM DMSO solution.
- White to off-white solid appearance for easy identification.
- Stable when stored under recommended conditions.
Medchemexpress LLC Lupenone | 1617-70-5 | 5 MG
Lupenone is an orally active lupine-type triterpenoid isolated from *Musa basjoo*. It impacts the PI3K/Akt/mTOR and NF-κB signaling pathways, exhibiting anti-inflammatory, antiviral, antidiabetic, and anticancer properties. It protects neuroblastoma SH-SY5y cells from methamphetamine-induced apoptotic cell death and improves type 2 diabetic nephropathy in db/db mouse models.
- Purity: 99.74%
- Appearance: solid, white to off-white
- Structure classification: terpenoids, triterpenes
- Source: plants (Leguminosae *Astragalus oleifolius* DC., Musaceae *Musa basjoo* Sieb. et Zucc., Compositae)
- Soluble in ethanol (10 mg/mL)