Enamines
Sigma Aldrich 4-(5-Chloromethyl-1,2,4-oxadiazol-3-yl)pyridine
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 4-(N,N-dimethylamino)phenylboronic acid, pinacol ester
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 5-Bromo-1,2,3-trifluorobenzene
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Methyl 3-aminocrotonate
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Diaminomaleonitrile
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 5-(Chloromethyl)-3-methyl-1H-1,2,4-triazole hydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Selleck Chemical LLC PF-562271 Besylate S2672-1g
PF-562271 Besylate is the benzenesulfonate salt of PF-562271 which is a potent ATP-competitive reversible inhibitor of FAK with IC50 of 1 5 nM 10-fold less potent for Pyk2 than FAK and 100-fold selectivity against other protein kinases except for some CDKs Phase 1
Selleck Chemical LLC PF-562271 Besylate S2672-50mg
PF-562271 Besylate is the benzenesulfonate salt of PF-562271 which is a potent ATP-competitive reversible inhibitor of FAK with IC50 of 1 5 nM 10-fold less potent for Pyk2 than FAK and 100-fold selectivity against other protein kinases except for some CDKs Phase 1
Medchemexpress LLC Molibresib besylate | 1895049-20-3 | 97.0% | 1 ML
Molibresib besylate is an orally active pan-BET inhibitor that targets and binds to BRD2, BRD3, BRD4, and BRDT. It competitively occupies acetylated lysine binding sites, disrupting the interaction between BET proteins and chromatin. This action inhibits MYC expression and target gene transcription, demonstrating broad antiproliferative activity by inhibiting cancer cell growth and inducing growth arrest.
- Inhibits cancer cell proliferation and induces cell cycle arrest.
- Downregulates mitosis-related genes and upregulates p-ERK1/2.
- Shows synergistic anti-proliferative effects with MEK inhibitors.
- Reduces tumor burden and prolongs survival in mouse models of leukemia.
- Applicable to research in acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, and other advanced solid tumors.
Medchemexpress LLC Molibresib besylate | 1895049-20-3 | 97.0% | 100 MG
Molibresib besylate is an orally active pan-BET inhibitor. It targets BRD2, BRD3, BRD4, and BRDT, disrupting their interaction with chromatin by occupying acetylated lysine binding sites. This inhibits MYC expression and target gene transcription. It exhibits broad antiproliferative activity, useful for research in acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, small-cell lung cancer, and other advanced refractory solid tumors.
- Disrupts BET protein-chromatin interaction
- Inhibits MYC expression and target gene transcription
- Exhibits broad antiproliferative activity
- Induces growth arrest and downregulates mitosis-related genes
- Upregulates p-ERK1/2 levels
- Shows synergistic effects with MEK inhibitors
- Modulates immune microenvironment and prolongs survival in models
Medchemexpress LLC Molibresib (besylate) | 1895049-20-3 | 97.0% | 50 MG
Molibresib besylate is an orally active pan-BET inhibitor that targets BRD2, BRD3, BRD4, and BRDT. It disrupts the interaction between BET proteins and chromatin, inhibiting MYC expression and target gene transcription. This compound exhibits broad antiproliferative activity, inhibiting cancer cell growth and inducing growth arrest. It is widely applicable to research related to acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, small-cell lung cancer, and various advanced refractory solid tumors.
- Orally active pan-BET inhibitor.
- Targets BRD2, BRD3, BRD4, and BRDT.
- Inhibits MYC expression and target gene transcription.
- Exhibits broad antiproliferative activity.
- Shows synergistic effect with MEK inhibitors.
- Applicable for research in acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, and small-cell lung cancer.