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Oximes

Organic compounds that have a carbon atom bonded to a nitrogen via a double bond and the nitrogen is bonded to a hydroxyl group, and have the general formula: RR'C=NOH, where R is an organic side-chain and R' may be hydrogen.

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Medchemexpress LLC Indirubin-3'-oxime | 667463-82-3 | >99.1% | 277.28 | 1 ML
SDP

Indirubin-3'-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3'-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3'-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes.

  • Potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β).
  • Directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3).
  • Can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Indirubin-3′-oxime | 667463-82-3 | 99.1% | 277.28 | 25 MG
SDP

Indirubin-3′-oxime (IDR3O) is a synthetic derivative of indirubin that functions as a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). It directly inhibits all three isoforms of JNK (JNK1, JNK2, and JNK3). This compound also promotes height growth through the activation of Wnt/β-catenin signaling in chondrocytes and is intended for research use only.

  • Potent inhibitor of cyclin-dependent kinases (CDKs)
  • Potent inhibitor of glycogen synthase kinase 3β (GSK3β)
  • Directly inhibits JNK1 (IC50: 0.8 μM), JNK2 (IC50: 1.4 μM), and JNK3 (IC50: 1.0 μM)
  • Enhances height growth by activating Wnt/β-catenin signaling in chondrocytes
  • Blocks c-Jun phosphorylation in cerebellar granule neurons (CGNs)
  • Prevents 6OHDA-induced decrease of nuclear localized MEF2D expression in PC12 cells
  • Enhances tibial longitudinal growth in mice
  • For research use only

ENCOMPASS_PREFERRED
3

eMolecules​ Ambeed / (2Z3E)-3-(Hydroxyimino)-[23-biindolinylidene]-2-one / 25mg / 632809158 / A164297 / / 667463-82-3 / MFCD02683594 / 277.283 / C16H11N3O2

Ambeed / (2Z3E)-3-(Hydroxyimino)-[23-biindolinylidene]-2-one / 25mg / 632809158 / A164297 / / 667463-82-3 / MFCD02683594 / 277.283 / C16H11N3O2

ENCOMPASS_PREFERRED