Alcohols and polyols

Organic compounds containing one or more hydroxyl functional groups bonded to a carbon atom; hydroxyls consist of an oxygen atom bonded to a hydrogen atom. Alcohols exist in chain, or as closed rings. Polyols contain two or more hydroxyl groups.

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4,741 – 4,755 of 5,342 results

4,741

BIOCHROM ULTRA NINHYDRIN KIT 8L NC

NC3968835 ULTRA NINHYDRIN KIT 8L NC

Pricing & Availability

4,742

Medchemexpress LLC Olprinone hydrochloride | 119615-63-3 | 99.9% | C14H11ClN4O | 50 MG

Olprinone Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, showing IC50s of 0.35 μM for PDE3. It is utilized in research for heart failure due to its positive inotropic and vasodilative effects, and also demonstrates anti-inflammatory activity.

Potent PDE3 inhibitor
Used in research for heart failure
Exhibits positive inotropic and vasodilative effects
Demonstrates anti-inflammatory activity
Modulates inflammation associated with myocardial ischemia-reperfusion injury
Reduces pro-inflammatory cytokines such as TNF-α and IL-1β
Decreases expression of adhesion molecules like ICAM-1 and P-Selectin
Inhibits apoptosis related to myocardial injury

Pricing & Availability

4,743

Medchemexpress LLC SCH-23390 (hydrochloride) | 125941-87-9 | 99.8% | 324.24 | 100 MG

SCH-23390 (hydrochloride) | 125941-87-9 | 99.8% | 324.24 | 100 MG

Pricing & Availability

4,744

Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG

Befiradol hydrochloride is a selective 5-HT1A receptor agonist provided for research use. It modulates serotonergic and dopaminergic activity in cortical regions and is used in preclinical pharmacology studies to investigate 5-HT1A-mediated mechanisms and models of neurological disorders. The material is supplied with supporting documentation for analytical and safety purposes.

Selective 5-HT1A receptor agonist for receptor pharmacology studies.
Demonstrated activity on dorsal raphe and medial prefrontal cortex neurotransmission.
High chemical purity suitable for analytical and in vivo research.
Supplied with certificate of analysis and safety data sheet.
Available in multiple pack sizes for small-scale and bulk use.
Not for human or clinical use; for research use only.

Pricing & Availability

4,745

Medchemexpress LLC Berubicin (hydrochloride) | 293736-67-1 | 95.08% | 670.10 | 5 MG

Berubicin hydrochloride is a Doxorubicin analog capable of crossing the blood-brain barrier. It inhibits P-gp and MRP1-mediated efflux, suppressing glioblastoma multiforme (GBM). This compound exhibits toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. It is suitable for studying nervous system-related tumors.

Can cross the blood-brain barrier
Inhibits P-gp and MRP1-mediated efflux
Suppresses glioblastoma multiforme (GBM)
Exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB)
Induces apoptosis in neuroblastoma cells
Useful in the study of nervous system-related tumors

Pricing & Availability

4,746

Medchemexpress LLC Verapamil hydrochloride | 152-11-4 | 100.0% | C27H39ClN2O4 | 1 ML

Verapamil hydrochloride, also known as (±)-Verapamil hydrochloride, functions as a calcium channel blocker and is identified as a potent, orally active first-generation P-glycoprotein (P-gp) inhibitor. This compound also exhibits inhibitory effects on CYP3A4. It holds potential for research applications related to conditions such as high blood pressure, heart arrhythmias, and angina.

Acts as a calcium channel blocker.
Functions as a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor.
Demonstrates inhibition of CYP3A4.
Suitable for research concerning high blood pressure.
Applicable for studies on heart arrhythmias.
Used in angina research.

Pricing & Availability

4,747

Medchemexpress LLC Azasetron hydrochloride | 123040-16-4 | 99.8% | C17H21Cl2N3O3 | 100 MG

Azasetron hydrochloride is a benzamide derivative that functions as a potent and selective antagonist of the 5-HT3 receptor, demonstrating an IC50 of 0.33 nM against this target. It has been investigated for its potential in studies related to chemotherapy-induced nausea and vomiting (CINV) and has shown the ability to penetrate the skin and enter systemic circulation in in vivo models.

Mechanism of action: Potent and selective 5-HT3 receptor antagonist.
Target affinity: IC50 of 0.33 nM for 5-HT3 receptor.
Chemical classification: Benzamide derivative.
Molecular formula: C17H21Cl2N3O3.
Molecular weight: 386.27.
Purity: 99.76%.
Physical characteristics: White to off-white solid.
Solubility: Soluble in water (20 mg/mL) and DMSO (2.22 mg/mL).
Research application: Used in CINV studies.
Pharmacokinetic property: Penetrates skin and enters systemic circulation in animal models.

Pricing & Availability

4,748

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 500 MG

Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. It shows high selectivity for AChE over BuChE and exhibits a neuroprotective effect on Aβ42 neurotoxicity. Its neuroprotective mechanism is related to the enhanced phosphorylation of Akt and GSK-3β and reduced phosphorylation of tau and glycogen synthase.

Reversible, selective AChE inhibitor
Shows high selectivity for AChE over BuChE
Exhibits neuroprotective effect on Aβ42 neurotoxicity
Neuroprotective mechanism is related to enhanced phosphorylation of Akt and GSK-3β
Reduced phosphorylation of tau and glycogen synthase

Pricing & Availability

4,749

Medchemexpress LLC Pargyline hydrochloride | 306-07-0 | 99.9% | C11H14ClN | 1 ML

Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM for MAO-A and 0.5 μM for MAO-B. It exhibits antihypertensive and anticancer activities. Pargyline (hydrochloride) is also a click chemistry reagent, containing an Alkyne group, which can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have Azide groups.

Irreversible monoamine oxidase (MAO) inhibitor
Inhibits MAO-A with a Ki of 13 μM
Inhibits MAO-B with a Ki of 0.5 μM
Demonstrates antihypertensive activities
Exhibits anticancer activities
Functions as a click chemistry reagent
Contains an Alkyne group for CuAAc reactions

Pricing & Availability

4,750

Medchemexpress LLC Prasugrel hydrochloride | 389574-19-0 | C20H21ClFNO3S | 500 MG

Prasugrel hydrochloride (PCR 4099 hydrochloride) is a thienopyridine and a proagent that inhibits platelet function. It is an orally active and potent P2Y12 receptor antagonist, which works by inhibiting ADP-induced platelet aggregation. In rat platelets, the active metabolite of Prasugrel hydrochloride inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC50 value of 1.8 μM.

Exhibits faster and significantly more potent antiplatelet effects in vivo compared to Clopidogrel.
Requires in vivo metabolic processing as an inactive prodrug to generate its active antiplatelet metabolite.
Rapidly absorbed from the gut following oral administration.
Achieves maximum plasma levels of active metabolite within 1 hour.
Leads to effective, maximum inhibition of platelet aggregation within 1-2 hours.

Pricing & Availability

4,751

Medchemexpress LLC PRT062607 hydrochloride (P505-15 hydrochloride) | 1370261-97-4 | C19H24ClN9O | 1 ML

PRT062607 Hydrochloride (P505-15 Hydrochloride) is an orally available Syk inhibitor with an IC50 of 1 nM. It inhibits inflammation and induces apoptosis, demonstrating potent antitumor activity in tumor xenograft mouse models. In vitro, it also exhibits significant activity against a variety of kinases, including Fgr, MLK1, Yes, Flt3, PAK5, Lyn, cSRC, Lck, Pyk, and FAK.

Inhibits phosphorylation of ERK(Y204), AKT(S473), and SYK(Y352) in Ramos cells
Inhibits BLNK Tyr84 phosphorylation
Induces apoptosis in human whole blood
Shows dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
Inhibits B-cell activation
Prevents tumor formation in mouse xenograft models

Pricing & Availability

4,752

Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.6% | C17H19ClN4O | 10 MM * 1 ML

Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist, utilized for irritable bowel syndrome (IBS) research. It blocks 5-HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons (IC50 ~55 nM), attenuates visceral nociceptive effects, and demonstrates anti-inflammatory effects.

Potent and highly selective serotonin 5-HT3 receptor antagonist.
Used for research of irritable bowel syndrome.
Blocks 5HT3-mediated depolarisation of neurons.
Attenuates visceral nociceptive effects.
Demonstrates anti-inflammatory effects.

Pricing & Availability

4,753

Medchemexpress LLC Alpelisib | 1217486-61-7 | C19H23ClF3N5O2S | 5 MG

Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM for p110α. It exhibits antineoplastic activity and potently inhibits Akt phosphorylation in cells transformed with PI3Kα.

Potently inhibits PIK3CA somatic mutations (H1047R, E545K; IC50s~4 nM).
Significantly reduces Akt phosphorylation in cells transformed with PI3Kα (IC50=74±15 nM).
Inhibits cell growth of osteosarcoma cell lines.
Induces G0/G1 phase cell cycle arrest in human and murine osteosarcoma cells.
Reduces tumor volumes and deposition of ectopic bone matrix in animal models.
Store powder at -20°C for 3 years or 4°C for 2 years.
Store in solvent at -80°C for 2 years or -20°C for 1 year.
Shipping can occur at room temperature if duration is less than 2 weeks.

Pricing & Availability

4,754

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG

EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.

Effective and selective DOT1L inhibitor
Reduces H3K79me2 and H3K79me1 levels
Down-regulates HOXA9 and MEIS1 expression
Selectively inhibits MLL rearrangement cell proliferation
Promotes differentiation and apoptosis of leukemia cells
Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
Demonstrates selectivity over other histone methyltransferases (HMTs)

Pricing & Availability

4,755

Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 5 MG

Dopexamine hydrochloride is a β2 adrenergic receptor agonist and a dopamine analogue with agonist activity at β2 and dopaminergic receptors. It can attenuate systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow. It also reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics.

β2 adrenergic receptor agonist
Dopamine analogue with agonist activity at β2 and dopaminergic receptors
Attenuates systemic inflammatory response
Reduces tissue leukocyte infiltration
Protects against organ injury
Reduces systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress

Pricing & Availability

Alcohols and polyols

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Medchemexpress LLC Olprinone hydrochloride | 119615-63-3 | 99.9% | C14H11ClN4O | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SCH-23390 (hydrochloride) | 125941-87-9 | 99.8% | 324.24 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Berubicin (hydrochloride) | 293736-67-1 | 95.08% | 670.10 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Verapamil hydrochloride | 152-11-4 | 100.0% | C27H39ClN2O4 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Azasetron hydrochloride | 123040-16-4 | 99.8% | C17H21Cl2N3O3 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pargyline hydrochloride | 306-07-0 | 99.9% | C11H14ClN | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Prasugrel hydrochloride | 389574-19-0 | C20H21ClFNO3S | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PRT062607 hydrochloride (P505-15 hydrochloride) | 1370261-97-4 | C19H24ClN9O | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Alosetron Hydrochloride | 122852-69-1 | 99.6% | C17H19ClN4O | 10 MM * 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Alpelisib | 1217486-61-7 | C19H23ClF3N5O2S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More