Alcohols and polyols
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Medchemexpress LLC Lidocaine hydrochloride hydrate | 6108-05-0 | 99.8% | 100 MG
Lidocaine hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. It decreases growth, migration, and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. It is an amide derivative with potential for the research of ventricular arrhythmia.
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Up-regulates miR-145 expression
- Inactivates MEK/ERK and NF-κB signaling pathways
- Potential for research of ventricular arrhythmia
- Causes completely reversible tail nerve block in rats
- Decreases cell proliferation in human gastric cancer cell line MKN45
- Inhibits MKN45 cell viability
- Increases apoptotic cell rate in MKN45 cells
- Down-regulates Cyclin D1 and up-regulates p21 expression
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Medchemexpress LLC Lidocaine hydrochloride hydrate | 6108-05-0 | 99.8% | 50 MG
Lidocaine hydrochloride hydrate is a sodium channel blocker that inhibits sodium channels with complex voltage and use dependence. It decreases the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating the MEK/ERK and NF-κB signaling pathways. This amide derivative shows potential for research into ventricular arrhythmia.
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Upregulates miR-145 expression
- Inactivates MEK/ERK and NF-κB signaling pathways
- Decreases cell proliferation and viability in MKN45 cells
- Increases apoptotic cell rate in MKN45 cells
- Down-regulates Cyclin D1 and up-regulates p21 expression in MKN45 cells