Sulfoxides
Apexbio Technology LLC Sulindac 38194-50-2 100mg
Sulindac (CAS 38194-50-2) is a nonsteroidal anti-inflammatory drug that functions as a prodrug and is metabolized in vivo to pharmacologically active sulindac sulfide and sulindac sulfone Sulindac sulfide acts as a cyclooxygenase inhibitor and modulates intracellular signaling pathways including the repression of ras activity Sulindac sulfone possesses antitumor properties independent of cyclooxygenase inhibition Due to these distinct metabolites and their activities sulindac is utilized in biomedical research for studying inflammatory processes cyclooxygenase-mediated pathways and the chemopreventive mechanisms involved in tumorigenesis
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC NR2F6 modulator-1 | 904449-84-9 | 99.5% | 419.45 | 100 MG
NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. It can be used for researching immune modulation and modulation of cancer stem cell activity.
- Potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator.
- Useful for researching immune modulation.
- Useful for researching modulation of cancer stem cell activity.
FOCUS BIOMOLECULES Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms)
Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms), UHMCP1 prevents the interaction (KD 80 uM) between the splicing factor SF3b155 and U2AF homology motif domain (UHM) U2AF65.1 The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displaying toxicity against HEK293 cells (EC50 140 uM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.
Medchemexpress LLC KAT modulator-1 | 1314006-43-3 | C20H36O2 | 5 MG
KAT modulator-1 is a compound identified as a KAT modulator that interacts with p300 full-length, but not its catalytic domain. It is provided as a solid and is intended for laboratory chemicals, manufacture of substances, and epigenetics research, including drug screening applications.
- Targets histone acetyltransferase
- Used in cancer research
- Interacts with p300 full-length
- Suitable for epigenetics research
- Identified for laboratory use and drug screening
- Provided as a solid
- For research use only
Medchemexpress LLC Smurf1 modulator-1 | 1825371-51-4 | 99.8% | 446.54 | 5 MG
Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with IC50 of 180 nM.
- Selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1) with an IC50 of 180 nM.
- For research use only.
Medchemexpress LLC Promethazine sulfoxide | 7640-51-9 | MFCD08063694 | 5mg
Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist Promethazine (HY-B1296) It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6