Sulfoxides
Medchemexpress LLC 2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG
2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 5 MG
CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor. It has Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R, and an IC50 value of 3.4 μM for FAAH. This compound can be used in studies related to cancer, deleterious inflammatory cascades in neurodegenerative diseases, and COVID-19 infection.
- Dual-targeting modulator: acts as a CB2R agonist and FAAH inhibitor.
- Can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
- At 10 μM, it reduces the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL6 in unstimulated monocytes and macrophages.
![Medchemexpress LLC 2-Quinoxalinecarboxamide, N-[2-[3-[(4-amino-1-piperidinyl)methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]- | 925437-38-3 | 96.2% | 483.59 | 500 UG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000385638-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Quinoxalinecarboxamide, N-[2-[3-[(4-amino-1-piperidinyl)methyl]imidazo[2,1-b]thiazol-6-yl]phenyl]- | 925437-38-3 | 96.2% | 483.59 | 500 UG
Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. It significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). This modulator regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases and inflammatory diseases. It also causes a significant decrease in MCP-1 expression in a human leukocyte (WBC) model, indicating its potential to inhibit inflammatory responses.
- Activates sirtuin activity.
- Downregulates MCP-1 expression.
- Upregulates FGF21 expression.
- Shows potential for studying metabolic diseases.
- Shows potential for studying inflammatory diseases.
Medchemexpress LLC Ramelteon metabolite M-II-d3 | 1246812-22-5 | 99.8% | 278.36 | C16H18D3NO3 | 1 MG
Ramelteon metabolite M-II-d3 is the deuterium-labeled form of Ramelteon metabolite M-II, provided for use as an internal standard or tracer in quantitative analytical methods. It is intended for analytical and research applications where a labeled reference compound improves accuracy and precision in mass spectrometry and NMR workflows.
- Deuterium-labeled internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, and LC-MS applications.
- High reported purity for accurate quantitation (≈99.8%).
- Provided in milligram-scale pack sizes for analytical use.
- Molecular weight 278.36 and chemical formula C16H18D3NO3.
Medchemexpress LLC Cb2r/faah modulator-2 | 2876918-68-0 | 367.52 g·mol⁻¹ | C24H33NO2 | 10 MG
CB2R/FAAH modulator-2 is a research-grade small-molecule dual-target modulator that acts as an agonist at the cannabinoid CB2 receptor and an inhibitor of fatty acid amide hydrolase (FAAH). It is supplied as a solid for in vitro and in vivo pharmacology studies involving cannabinoid signaling and endocannabinoid metabolism. The compound has CAS 2876918-68-0, molecular formula C24H33NO2, and molecular weight 367.52 g·mol⁻¹.
- Dual CB2R agonist and FAAH inhibitor.
- Suitable for in vitro and in vivo pharmacology studies.
- Provided as a solid, with an option as 10 mM in DMSO solution.
- Available in small research sizes, for example 10 mg.
- CAS number 2876918-68-0 for unambiguous identification.
- Recommended storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
Medchemexpress LLC Quetiapine sulfoxide dihydrochloride | 329218-11-3 | MFCD09031385 | 98.6% | 472.43 g·mol-1 | C21H27Cl2N3O3S | 10 MG
Quetiapine sulfoxide dihydrochloride is the dihydrochloride salt of quetiapine sulfoxide, a primary metabolite of the antipsychotic quetiapine. It is provided as a research-grade biochemical reference for analytical, metabolic, and pharmacokinetic studies.
- Main metabolite of quetiapine used in metabolism research and metabolite identification.
- Provided as a stable dihydrochloride salt to improve solubility and handling.
- High purity suitable for analytical and reference-standard applications.
- Available in small milligram pack sizes and as a 10 mM solution for assay preparation.
Sigma Aldrich Fine Chemicals Biosciences 1,2-Bis(phenylsulfinyl)ethane palladium(II) acetate | 858971-43-4 | MFCD09842752 | 250MG
1,2-Bis(phenylsulfinyl)ethane palladium(II) acetate | Mol Wt: 502.9 | 858971-43-4 | MFCD09842752 | 250MG
Medchemexpress LLC CB2R/FAAH modulator-2 | 2876918-68-0 | C24H33NO2 | 1 ML
CB2R/FAAH modulator-2 is a dual targeting modulator functioning as a CB2R agonist and FAAH inhibitor. It has Ki values of 10.8 nM for CB2R and 152.9 nM for CB1R, and an IC50 value of 6.2 μM for FAAH. This modulator can be utilized in studies related to cancer, neurodegenerative diseases, and COVID-19 infection. In vitro, it has been shown to reduce the production of pro-inflammatory cytokines such as TNFα, IFN-γ, IL-1 ß, and IL6 in unstimulated monocytes and macrophages.
- Acts as a CB2R agonist
- Functions as a FAAH inhibitor
- Relevant for studies on cancer
- Useful in research on neurodegenerative diseases
- Applicable to COVID-19 infection studies
- Reduces production of pro-inflammatory cytokines
TARGETMOL CHEMICALS INC TETRABENAZINE METABOLITE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tetrabenazine Metabolite ((-)-(beta)-HTBZ) a vesicles monoamine transporter 2 (VMAT2) inhibitor is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetrabenazine Metabolite is often used to study chorea associated with Huntington's disease and other hyperactivity disorders. purity: 95%
eMolecules 67-68-5 | Dimethyl Sulfoxide | AA Blocks LLC | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 25g | 598385588
Dimethyl Sulfoxide | AA Blocks LLC | 67-68-5 | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 25g | 598385588
Medchemexpress LLC NR2F6 modulator-1 | 904449-84-9 | 99.5% | 419.45 | 25 MG
NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. This compound can be utilized for researching immune modulation and the modulation of cancer stem cell activity.
- Potent NR2F6 modulator
- Can be used for researching immune modulation
- Useful for modulation of cancer stem cell activity
- Appears as an off-white to light yellow solid
- Soluble in DMSO (125 mg/mL)
- In vivo solubility in 10% DMSO, 90% corn oil (≥ 2.08 mg/mL)
Medchemexpress LLC mGluR3 modulator-1 | 374548-18-2 | C16H21N3O | 5 MG
mGluR3 modulator-1 (compound 3) is a mGluR3 modulator with an EC50 of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay. It is intended for research use only.
- Solid, white to off-white appearance
- Purity of 98.67%
- Molecular weight: 271.36
- Can be stored as powder at -20°C for 3 years, or 4°C for 2 years
- Can be stored in solvent at -80°C for 6 months, or -20°C for 1 month
- Soluble in DMSO at 125 mg/mL
Medchemexpress LLC N'-(3-acetylphenyl)-N-(3-(2-methoxyethyl)-2,4-dioxo-1-(2-(piperidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinazolin | 2946701-09-1 | 99.3% | 507.58 g/mol | C27H33N5O5 | 10 MG
COP1-ATGL modulator 1 is an orally active small-molecule research reagent that modulates the COP1-ATGL pathway. It increases ATGL protein expression, reduces ATGL and COP1 ubiquitination, and diminishes lipid accumulation in hepatocytes at nanomolar concentrations. Supplied as a white to off-white solid with high purity and defined storage recommendations for powder and solution.
- Orally active modulator of COP1-ATGL signaling.
- Increases ATGL protein expression at nanomolar concentrations.
- Reduces ATGL and COP1 ubiquitination in cellular assays.
- High purity suitable for research applications.
- Stable solid with recommended low-temperature storage.
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 10MM/1ML
GLP-1R modulator C16 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site.
- Enhances GLP-1 binding to GLP-1R
- Operates via a transmembrane site
- Purity of 98.7%
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.71% | 522.68 | 1 ML
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. It is for research use only and not sold to patients. This modulator offers protection against cardiac injury.
- Potent CXCR7-binding affinity (Ki=13 nM).
- β-arrestin activity (EC50=11 nM).
- Improved selectivity in the GPCR panel.
- Improved therapeutic index in the hERG patch-clamp assay.
- Moderate to high in vitro turnover in NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells).
- Good aqueous solubility.
- Rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL at 0.25 h (Tmax).
- Reduces cardiac fibrosis in an isoproterenol-induced cardiac injury model in mice.