Sulfoxides
Medchemexpress LLC CRBN modulator-1 | 2407829-65-4 | 98.0% | 324.29 | 25 MG
CRBN modulator-1 is a Thalidomide analog and a CRBN modulator, extracted from WO2020006262A1, compound 10. It has an IC₅₀ of 3.5 μM and a Kᵢ of 0.98 μM. This product is for research use only.
- Thalidomide analog and CRBN modulator.
- IC₅₀ of 3.5 μM.
- Kᵢ of 0.98 μM.
- For research use only.
Medchemexpress LLC Kv3 modulator 2 | 2101321-76-8 | 99.9% | 25 MG
Kv3 modulator 2 is a potent Kv3 channels modulator, extracted from patent WO2018109484A1. It exhibits analgesic activity and is utilized in the prophylaxis or treatment of related disorders. This compound is for research use only and is not intended for patient use. It has a molecular weight of 379.41 and a chemical formula of C21H21N3O4, appearing as a solid that is white to off-white in color.
- Potent Kv3 channels modulator
- Exhibits analgesic activity
- Used in the prophylaxis or treatment of related disorders
- For research use only
- Molecular weight: 379.41
- Chemical formula: C21H21N3O4
- Appearance: Solid, white to off-white
- Shipped at room temperature in the continental US
- Storage conditions: 4°C sealed, away from moisture and light; in solvent: -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture and light)
- Solubility: 100 mg/mL in DMSO
Medchemexpress LLC MicroRNA modulator-2 | 438599-31-6 | 99.5% | 432.49 g·mol⁻¹ | C23H20N4O3S | 10 MG
MicroRNA modulator-2 is an oxadiazole-class small molecule inhibitor of microRNA-21 (miR-21) with an AC50 of 16.48 μM. Supplied as a solid for research use, it is intended for in vitro miRNA inhibition studies and related cancer research. Molecular formula C23H20N4O3S; molecular weight 432.49 g·mol⁻¹.
- Oxadiazole-class small molecule inhibitor of miR-21.
- AC50 16.48 μM in reported assays.
- High purity (≈99.5%).
- Supplied as a solid; common size 10 mg.
- Suitable for in vitro cellular and biochemical miRNA studies.
- Store at -20°C; for research use only.
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | MFCD00869764 | 99.88% | 250 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. It can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM).
- Selectively reduces Aβ42 production.
- Useful for Alzheimer's disease research.
Medchemexpress LLC Sulindac sulfide | 49627-27-2 | MFCD00078044 | 98.1% | 1 ML
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, demonstrating an IC50 of 20.2 μM for γ42-secretase activity. This compound is primarily utilized in neurological disease research, targeting drug metabolites and γ-secretase.
- Noncompetitive γ-secretase inhibitor
- IC50 of 20.2 μM for γ42-secretase activity
- Targeted for drug metabolite research
- Used in neurological disease studies
Medchemexpress LLC Niraparib carboxylic acid metabolite M1 | 1476777-06-6 | 99.7% | 321.37 g/mol | C19H19N3O2 | 10 MG
Niraparib metabolite M1 is the primary carboxylic acid metabolite of the PARP inhibitor niraparib, provided as a solid research reagent for in vitro and analytical use.
- High purity (99.69%) suitable for analytical and research applications.
- Molecular formula C19H19N3O2; molecular weight 321.37 g/mol.
- Solid, light brown to brown appearance.
- Supplied at 10 mg quantity.
- Soluble in DMSO at ≥ 100 mg/mL (in vitro).
- Recommended storage: powder at -20°C (up to 3 years); in solvent at -80°C (up to 2 years).
- Intended for laboratory research use only; not for human therapeutic use.
Medchemexpress LLC Ramelteon metabolite M-II-d3 | 1246812-22-5 | 99.8% | 278.36 | C16H18D3NO3 | 1 MG
Ramelteon metabolite M-II-d3 is the deuterium-labeled form of Ramelteon metabolite M-II, provided for use as an internal standard or tracer in quantitative analytical methods. It is intended for analytical and research applications where a labeled reference compound improves accuracy and precision in mass spectrometry and NMR workflows.
- Deuterium-labeled internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, and LC-MS applications.
- High reported purity for accurate quantitation (≈99.8%).
- Provided in milligram-scale pack sizes for analytical use.
- Molecular weight 278.36 and chemical formula C16H18D3NO3.
Medchemexpress LLC Cytochrome P450 17A1 Antibody (YA478) | 57 kDa | 10 UL
This Cytochrome P450 17A1 Antibody (YA478) is supplied as a liquid and is suitable for various laboratory applications. It is stable under recommended storage conditions and intended for research use only.
- Host: Rabbit
- Reactivity: Human, mouse, rat
- Clonality number: YA478
- SwissProt ID: P05093
- Gene ID: 1586
- Appearance: Liquid
- Concentration: 1.0 mg/mL
- Conjugation: Non-conjugated
- Application: WB, ICC/IF, IHC-P, FC
- Dilution ratio: WB: 1:500; ICC/IF: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:100
- Formulation: Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles.
- Shipping: Shipping with blue ice.
- Molecular weight: 57 kDa
Apexbio Technology LLC Sulindac 38194-50-2 100mg
Sulindac (CAS 38194-50-2) is a nonsteroidal anti-inflammatory drug that functions as a prodrug and is metabolized in vivo to pharmacologically active sulindac sulfide and sulindac sulfone Sulindac sulfide acts as a cyclooxygenase inhibitor and modulates intracellular signaling pathways including the repression of ras activity Sulindac sulfone possesses antitumor properties independent of cyclooxygenase inhibition Due to these distinct metabolites and their activities sulindac is utilized in biomedical research for studying inflammatory processes cyclooxygenase-mediated pathways and the chemopreventive mechanisms involved in tumorigenesis
TARGETMOL CHEMICALS INC Sulindac sulfone 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes.Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM). Purity 98.19%