Sulfoxides
Medchemexpress LLC Dl-sulforaphane n-acetyl-l-cysteine | 334829-66-2 | 99.9% | 340.48 g/mol | C11H20N2O4S3 | 5 MG
DL-Sulforaphane N-acetyl-L-cysteine is a sulforaphane metabolite used in research as an orally active histone deacetylase (HDAC) inhibitor. It is reported to have an extended half-life and improved blood-brain barrier permeability versus the parent compound, and has been used to study autophagy, HDAC activity, and anticancer mechanisms. Supplied as a high-purity solid for laboratory research.
- Orally active HDAC inhibitor and sulforaphane metabolite.
- Longer half-life and improved blood-brain barrier permeability compared with parent compound.
- Reported to induce autophagy, cell-cycle arrest, and apoptosis in certain cancer cell lines.
- High-purity solid suitable for research applications.
- Soluble in DMSO; store powder frozen for long-term stability.
Medchemexpress LLC NR2F6 modulator-1 | 904449-84-9 | 99.5% | 419.45 | 50 MG
NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. It can be used for researching immune modulation and modulation of cancer stem cell activity.
- Potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator
- Useful for immune modulation research
- Useful for cancer stem cell activity modulation research
- Appearance: solid
- Color: off-white to light yellow
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 100 MG
CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor. It has Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R, and an IC50 value of 3.4 μM for FAAH.
- Dual-targeting modulator
- Acts as a CB2R agonist
- Acts as a FAAH inhibitor
- Can be used in studies related to cancer
- Can be used in studies related to deleterious inflammatory cascades occurring in neurodegenerative diseases
- Can be used in studies related to COVID-19 infection
![Medchemexpress LLC 1-(2-(dimethylamino)ethyl)-3-(7-methylbenzo[1,2-d:3,4-d']bis(thiazole)-2-yl)urea | 1428729-63-8 | MFCD31619259 | 99.5% | 335.45 g/mol | C14H17N5OS2 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241718.png-250.jpg)
Medchemexpress LLC 1-(2-(dimethylamino)ethyl)-3-(7-methylbenzo[1,2-d:3,4-d']bis(thiazole)-2-yl)urea | 1428729-63-8 | MFCD31619259 | 99.5% | 335.45 g/mol | C14H17N5OS2 | 25 MG
RIG-1 modulator 1 is a small-molecule antiviral research compound reported to modulate the RIG-1 pathway and to have activity against influenza virus, hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV. The product is supplied as a solid (white to light yellow) for research use and is accompanied by supporting documentation such as a certificate of analysis and safety data sheet.
- Small-molecule RIG-1 pathway modulator.
- Reported activity against influenza, HBV, HCV, and HIV.
- High reported purity suitable for research applications.
- Supplied as a solid with documented appearance and handling information.
- Available with COA and SDS for quality and safety verification.
Medchemexpress LLC IL-17 modulator 3 | 2467731-88-8 | 99.51% | 579.73 | 1 ML
IL-17 modulator 3 is an IL-17 modulator that can be used for the research of inflammation, cancer, and autoimmune diseases. This product is for research use only and not sold to patients.
- Used for research of inflammation
- Used for research of cancer
- Used for research of autoimmune diseases
Medchemexpress LLC (+)-LRH-1 modulator-1 | 00-00-0 | 99.4% | C28H36N2O2S | 10MG
(+)-LRH-1 modulator-1 is the (+)-stereoisomer of an LRH-1 modulator and functions as a potent agonist of liver receptor homolog-1 (LRH-1). It modulates inflammatory signaling in intestinal organoid models by inducing IL-10 and reducing IL-1β and TNFα. The compound is provided as a high-purity research-grade small molecule for cellular and biochemical studies of LRH-1 pathways.
- Potent LRH-1 modulator/agonist for receptor pharmacology studies.
- Induces anti-inflammatory cytokine IL-10 in organoid models.
- Reduces proinflammatory cytokines IL-1β and TNFα in assays.
- High purity suitable for cellular and biochemical experiments.
- Available in multiple small-scale quantities for research use.
Medchemexpress LLC Ramelteon metabolite M-II-d3 | 1246812-22-5 | 99.8% | 278.36 g/mol | C16H18D3NO3 | 5 MG
Ramelteon metabolite M-II-d3 is the deuterium-labeled analog of the major human metabolite of ramelteon, provided as a high-purity reference standard intended for use as a tracer or internal standard in quantitative analytical methods. It is supplied as a solid suitable for laboratory analysis.
- Deuterium-labeled internal standard for quantitative analysis.
- High purity suitable for analytical work.
- Supplied as a white to off-white solid for ease of handling.
- Compatible with NMR, GC-MS, and LC-MS workflows.
- Molecular weight approximately 278.36 g/mol for accurate calculations.
Cayman Chemical Sulindac sulfide
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
Medchemexpress LLC GLP-1R modulator L7-028 | 2648317-95-5 | 99.47% | C24H28N2O3 | 50 MG
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site.
- Functions as an allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Acts via a transmembrane site
- Has an EC50 of 11.01 ± 2.73 μM
Cayman Chemical Sulforaphane Inhibitors
An isothiocyanate that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression; at 15 μM, inhibits class I and II HDAC activity and suppresses tumor growth selectively in cancerous prostate epithelial cells without affecting normal cells
Medchemexpress LLC (R)-IL-17 modulator 4 | 2446804-29-9 | 99.6% | C27H34N6O2 | 25 MG
(R)-IL-17 modulator 4 is the R-configure of IL-17 modulator 4. This compound is a proagent of IL-17 modulator 1, an orally active, highly efficacious IL-17 modulator. It is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome.
- Target: IL-17
- Research applications include inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome
- Appearance: Solid
- Color: Off-white to gray
- Molecular weight: 474.60
- Solubility in DMSO: 100 mg/mL
Medchemexpress LLC Glp-1r modulator l7-028 | 2648317-95-5 | 99.5% | C24H28N2O3 | 1 ML
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R through a transmembrane site, with an EC50 of 11.01 ± 2.73 μM.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R via a transmembrane site
Medchemexpress LLC IL-17 modulator 1 (disodium) | 2446803-91-2 | 98.4% | C28H35N6Na2O6P | 25 MG
IL-17 modulator 1 disodium is an orally active, highly efficacious small molecule IL-17 modulator. It is designed for research into diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis. The disodium salt form provides enhanced water solubility and stability, making it suitable for various research applications.
- Orally active and highly efficacious small molecule
- Enhanced water solubility and stability
- Useful for research into psoriasis
- Useful for research into ankylosing spondylitis
- Useful for research into psoriatic arthritis