Sulfoxides
Medchemexpress LLC Lithium dodecyl sulf 5g
Lithium dodecyl sulfate is an anionic detergent and surfactant that can be used in place of SDS for electrophoresis under low temperatures Lithium dodecyl sulfate can be used for synthesis of nanomaterials and chromatography[1]
Apexbio Technology LLC Sulindac sulfone 59864-04-9 10mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
Sigma Aldrich Fine Chemicals Biosciences Methyl sulfoxide >=99%, FG | 67-68-5 | MFCD00002089 | 10KG
Methyl sulfoxide >=99%, FG | Purity: >=99% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 10KG
FOCUS BIOMOLECULES Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms)
Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms), UHMCP1 prevents the interaction (KD 80 uM) between the splicing factor SF3b155 and U2AF homology motif domain (UHM) U2AF65.1 The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displaying toxicity against HEK293 cells (EC50 140 uM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.
Cayman Chemical SulIndac sulfon 5mg
An oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats; generally considered to be inactive against COX enzymes, although it can reduce azoxymethane-induced colon cancer in rats; inhibits aldose reductase (IC50 = 367 nM) in vitro
Medchemexpress LLC KAT modulator-1 (Compound 3) | 1314006-43-3 | 98.0% | 308.50 | C20H36O2 | 10 MG
KAT modulator-1 is a small-molecule modulator of lysine acetyltransferase (KAT) activity developed for epigenetics research. It has been shown to interact with full-length p300 but not with the isolated catalytic domain, making it a useful probe for studying KAT-protein interactions and regulatory mechanisms in biochemical and cell-based assays. The compound is supplied as a solid with documented storage recommendations and analytical data.
- Modulates lysine acetyltransferase (KAT) activity.
- Interacts with full-length p300 but not the catalytic domain.
- Suitable for biochemical and cell-based epigenetics studies.
- Supplied as a solid with defined storage stability.
- Molecular formula C20H36O2 and molecular weight 308.50.
- High chemical purity typically reported (about 98%).
TARGETMOL CHEMICALS INC Secretase modulator 13 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. gamma-Secretase modulator 13 is a gamma-secretase modulator (GSMs) that inhibits the production of amyloid beta-peptide Abeta42 and can be used to study Alzheimer's disease and tumors. Purity 99.68%
Medchemexpress LLC Hsp110/sGC-modulator-1 | 99.6% | 490.86 g·mol⁻1 | C24H18ClF3N2O4 | 10 MG
Hsp110/sGC-modulator-1 is an orally active small-molecule regulator that modulates Hsp110 and soluble guanylate cyclase (sGC). It demonstrates potent dual-target activity, produces vasodilatory effects, and attenuates pulmonary vascular remodeling and right ventricular hypertrophy in preclinical studies. Supplied in milligram quantities for research use only. Molecular formula C24H18ClF3N2O4; molecular weight 490.86 g·mol⁻1; reported purity 99.58%.
- Dual-target activity against Hsp110 and sGC.
- Demonstrated vasodilatory and antiproliferative effects in preclinical models.
- Suitable for in vitro and in vivo preclinical research.
- Supplied in milligram quantities for screening and lead optimization.
- Reported purity 99.58% and characterized by HRMS.