Sulfoxides
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 25 MG
CB2R/FAAH modulator-3 is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor. It has potential applications in studies related to cancer, neurodegenerative diseases, and COVID-19 infection.
- Acts as a dual-targeting modulator
- Functions as a CB2R agonist and FAAH inhibitor
- Exhibits Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R
- Has an IC50 value of 3.4 μM for FAAH
- Reduces pro-inflammatory cytokines such as TNFα, IFN-γ, IL-1β, and IL6 in unstimulated monocytes and macrophages at 10 μM
Medchemexpress LLC Bithionol (sulfoxide) | 844-26-8 | 99.0% | 372.05 | 100 MG
Bithionol sulfoxide is an anti-infection agent specifically used for parasites. It exhibits mutagenic activity. This compound is utilized in research concerning parasitic infections such as paragonimiasis, flukes, and cestodes infection.
- Functions as an anti-infection agent targeting parasites.
- Observed to possess mutagenic activity.
- Suitable for research applications related to parasitic infections.
- Can be used for research into parasitic infections including paragonimiasis, flukes, and cestodes infection.
Medchemexpress LLC IRAK4 modulator-2 | 1356013-27-8 | 99.9% | 399.87 | 5 MG
IRAK4 modulator-2 | 1356013-27-8 | 99.9% | 399.87 | 5 MG
Medchemexpress LLC Quetiapine sulfoxide dihydrochloride | 329218-11-3 | MFCD09031385 | 98.6% | 472.43 g·mol-1 | C21H27Cl2N3O3S | 10 MG
Quetiapine sulfoxide dihydrochloride is the dihydrochloride salt of quetiapine sulfoxide, a primary metabolite of the antipsychotic quetiapine. It is provided as a research-grade biochemical reference for analytical, metabolic, and pharmacokinetic studies.
- Main metabolite of quetiapine used in metabolism research and metabolite identification.
- Provided as a stable dihydrochloride salt to improve solubility and handling.
- High purity suitable for analytical and reference-standard applications.
- Available in small milligram pack sizes and as a 10 mM solution for assay preparation.
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 99.6% | 408.89 g·mol⁻1 | C21H26ClFN2O3 | 5 MG
GLP-1R modulator C16 is a small-molecule allosteric modulator that enhances GLP-1 binding to the GLP-1 receptor via a transmembrane site (CAS 875005-43-9). It is characterized in vitro with an EC50 of 8.43 ± 3.82 μM, a molecular weight of 408.89 g·mol⁻1, and high chemical purity suitable for research applications.
- Allosteric modulator of GLP-1 receptor activity.
- Characterized potency (EC50 8.43 ± 3.82 μM) for in vitro studies.
- High chemical purity (99.6%) for reproducible results.
- Compact quantities suitable for early-stage pharmacology.
- Useful for studying GLP-1R pharmacology and GPCR signaling.
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 50 MG
CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor, with Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R, and an IC50 value of 3.4 μM for FAAH. At 10 μM, it reduces the production of pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL6 in unstimulated monocytes and macrophages. This modulator can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
- Molecular weight: 341.49
- Formula: C22H31NO2
- CAS no.: 2876918-67-9
- Appearance: Solid
- Color: White to off-white
- Purity: 99.71%
Medchemexpress LLC Ramelteon metabolite M-II-d3 | 1246812-22-5 | 99.8% | 278.36 | C16H18D3NO3 | 1 MG
Ramelteon metabolite M-II-d3 is the deuterium-labeled form of Ramelteon metabolite M-II, provided for use as an internal standard or tracer in quantitative analytical methods. It is intended for analytical and research applications where a labeled reference compound improves accuracy and precision in mass spectrometry and NMR workflows.
- Deuterium-labeled internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, and LC-MS applications.
- High reported purity for accurate quantitation (≈99.8%).
- Provided in milligram-scale pack sizes for analytical use.
- Molecular weight 278.36 and chemical formula C16H18D3NO3.
Medchemexpress LLC 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(2-oxo-2-phenylethyl)-1-(2-phenylethyl)- | 421578-93-0 | 99.81% | C24H21NO3 | 1 ML
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). This compound is for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Via a transmembrane site
Medchemexpress LLC N'-(3-acetylphenyl)-N-(3-(2-methoxyethyl)-2,4-dioxo-1-(2-(piperidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinazolin | 2946701-09-1 | 99.3% | 507.58 g/mol | C27H33N5O5 | 10 MG
COP1-ATGL modulator 1 is an orally active small-molecule research reagent that modulates the COP1-ATGL pathway. It increases ATGL protein expression, reduces ATGL and COP1 ubiquitination, and diminishes lipid accumulation in hepatocytes at nanomolar concentrations. Supplied as a white to off-white solid with high purity and defined storage recommendations for powder and solution.
- Orally active modulator of COP1-ATGL signaling.
- Increases ATGL protein expression at nanomolar concentrations.
- Reduces ATGL and COP1 ubiquitination in cellular assays.
- High purity suitable for research applications.
- Stable solid with recommended low-temperature storage.
Cayman Chemical Sulindac sulfide
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 10MG
Mutant p53 modulator-1 is a small-molecule research reagent reported to modulate mutant p53 and to reduce progression of cancers harboring p53 mutations. It is supplied as a powder for laboratory research and includes stability instructions for storage and handling.
- High purity: 99.9% suitable for analytical and biological studies.
- Defined chemical formula: C27H32F4N8O2 for unambiguous identification.
- Documented stability: powder stable at -20°C for long-term storage.
- Reported activity against mutant p53 to support targeted cancer research.
- Intended for research use only, not for human or clinical use.
Medchemexpress LLC Sulindac sulfide | 49627-27-2 | 98.1% | 100 MG
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity. For research use only. MedChemExpress does not sell to patients.
- Solubility in vitro: DMSO at 50 mg/mL (146.88 mM), requires ultrasonic assistance, use newly opened DMSO due to hygroscopic nature.
- Stock solution storage: -80°C for 6 months; -20°C for 1 month.
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage of powder: -20°C for 3 years; in solvent: -80°C for 6 months, -20°C for 1 month.