Sulfoxides
TARGETMOL CHEMICALS INC ABEMACICLIB METABOLITE M 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Abemaciclib metabolite M20 (CDK4/6-IN-4) is an active metabolite of Abemaciclib. Abemaciclib metabolite M20 is a selective CDK4/6 inhibitor and can be used for researches on the treatment of cancer. purity: 98%
Medchemexpress LLC Fast garnet GBC sulfate salt | 101-89-3 | MFCD00011883 | 90.0% | 334.35 g/mol | C14H14N4O4S | 250 MG
Fast garnet GBC sulfate salt, 90% is a chromogenic substrate for alkaline phosphatase used to detect and visualize enzyme activity in histochemical and biochemical assays. It is supplied as a brown to black solid powder with a stated purity of 90% and is offered in multiple laboratory-scale pack sizes.
- Chromogenic substrate for alkaline phosphatase.
- Provides visible staining to localize enzymatic activity in tissue and cell samples.
- Supplied as a solid powder, brown to black in appearance.
- Stated purity of 90.0% supports consistent staining performance.
- Available in multiple laboratory pack sizes for flexible use.
- Molecular formula C14H14N4O4S, molecular weight 334.35 g/mol.
TARGETMOL CHEMICALS INC 5-HT1A MODULATOR 1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. 5-HT1A modulator 1 displays very high affinities for the 5-HT1A (alpha)1-adrenergic receptor and D2 receptor (IC50s = 2 nM 10 nM and 40 nM). purity: 99%
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | 99.88% | 50 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. It can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM)
- Selectively reduces Aβ42 production
- Used for researching Alzheimer's disease
Medchemexpress LLC IL-17A modulator-1 | 2748749-29-1 | 98.8% | C33H31N5O4 | 25 MG
IL-17A modulator-1 is a compound that modulates the activity of IL-17A, an important cytokine involved in immune responses. Derived from patent WO2021239743+A1, this modulator inhibits the biological action of IL-17A with a pIC50 of 8.2, making it suitable for research into various diseases and disorders associated with IL-17A activity, including those with immune components, autoimmune pathologies, cancer, and neurodegenerative disorders. The product is provided as a white to off-white solid.
- Modulates IL-17A activity
- Inhibits biological action of IL-17A
- Suitable for research into immune, autoimmune, cancer, and neurodegenerative disorders
- White to off-white solid appearance
Medchemexpress LLC Hydrazinecarbothioamide, 2-(1H-indol-3-ylmethylene)-N-(4-methylphenyl)-, (2E)- | 2097787-75-0 | 99.0% | 308.40 | 5 MG
Nur77 modulator 3 (HY-162147) is a chemical compound intended for research use only. It has a molecular weight of 308.40 and exhibits a high purity of 99.01% via HPLC analysis. This compound is identified by its CAS Number 2097787-75-0 and the chemical name Hydrazinecarbothioamide, 2-(1H-indol-3-ylmethylene)-N-(4-methylphenyl)-, (2E)-.
- Provided as a white to off-white solid
- Structure confirmed by ¹H NMR and LCMS
- High purity of 99.01% verified by HPLC
- Powder storage recommended at -20°C for up to 3 years
- In-solvent storage recommended at -80°C for 6 months or -20°C for 1 month
- Complies with specified quality standards
Apexbio Technology LLC Sulindac sulfone 59864-04-9 10mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
Medchemexpress LLC D-galactose-6-O-sulfate sodium salt | 125455-62-1 | MFCD00078771 | 95.0% | 282.20 g/mol | C6H11NaO9S | 5 MG
D-Galactose-6-O-sulfate sodium salt is the sodium salt form of D-galactose 6-sulfate supplied as a biochemical reagent for life-science research. It is intended for use as a biological material or organic compound in laboratory assays and analytical applications where a sulfated galactose derivative is required.
- Used as a biochemical reagent for life-science research.
- Sodium salt form for improved aqueous solubility.
- High purity (95.0%).
- Suitable for use as a biological material or organic compound in assays.
- Available in milligram pack sizes for small-scale experiments.
- Identified by CAS 125455-62-1 and formula C6H11NaO9S.
Medchemexpress LLC Sulindac-d3 | 99.4% | C20H14D3FO3S | 5 MG
Sulindac-d3 is a deuterium labeled non-steroidal anti-inflammatory agent that acts as a COX-2 inhibitor, inhibiting its overexpression. It is supplied as a light yellow to yellow solid.
- Deuterium labeled Sulindac
- Non-steroidal anti-inflammatory agent
- Acts as a COX-2 inhibitor
- Purity: 99.4% (HPLC)
- Isotopic enrichment: 99.8%
- Storage (powder): -20°C for 3 years
- Storage (in solvent): -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Sirtuin modulator 1 | 2070015-26-6 | 99.85% | 606.20 | 100 MG
Sirtuin modulator 1 is a compound that acts as a modulator of SIRTl, a homolog of SIRT3. This compound has an EC1.5 of less than 1 μM and was extracted from patent WO 2010071853 A1, Compound No.4.
- Modulator of SIRTl, a homolog of SIRT3
- High purity of 99.85%
- Solid appearance, light yellow to yellow color
- Molecular weight of 606.20
- Soluble in DMSO at 12.5 mg/mL
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.7% | 522.68 | 100 MG
CXCR7 modulator 2 is a small molecule modulator of C-X-C Chemokine Receptor Type 7 (CXCR7) with a Ki of 13 nM. This compound exhibits potent CXCR7-binding affinity and β-arrestin activity, offering improved selectivity in GPCR panels and an enhanced therapeutic index in hERG patch-clamp assays. It demonstrates good aqueous solubility and is suitable for research applications.
- Potent CXCR7-binding affinity (Ki=13 nM)
- Beta-arrestin activity (EC50=11 nM)
- Improved selectivity in GPCR panel
- Improved therapeutic index in hERG patch-clamp assay
- Moderate to high in vitro turnover
- Good aqueous solubility
- Rapidly absorbed in vivo
- Reduces cardiac fibrosis in injury models
- Soluble in DMSO
Medchemexpress LLC Sirtuin modulator 1 | 2070015-26-6 | MFCD29924722 | 99.9% | 10 MG
Sirtuin modulator 1 is a small-molecule modulator of SIRT1 (a homolog of SIRT3) reported with an EC1.5 of <1 μM and described in patent WO 2010071853 A1 (Compound No. 4). Supplied as a high-purity solid for research use, it is intended for biochemical and cellular studies of sirtuin activity.
- High reported purity for assay-ready use.
- Molecular formula C31H32ClN5O2S2, molecular weight 606.20 g/mol.
- CAS number 2070015-26-6 for unambiguous identification.
- Reported EC1.5 potency of <1 μM against SIRT1.
- Available in milligram-scale quantities suitable for research.