Thioureas
AdipoGen Zoxamide
Chemical. CAS 156052-68-5. Formula C14H16Cl3NO2. MW 336.6. Synthetic. Fungicide. Primarily an oomycete fungicide although it has some activity against ascomycetes and basidiomycetes. The product acts by disruption of the microtubule structure and inhibition of cell division. The mechanism for this activity is through the covalent binding of the active ingredient to beta-tubulin in the cytoskeleton. Scanning microscopy studies showed zoxamide action against blight on potato crops begins after germination, achieving inhibition of hyphal development and sporangia production. This novel mode of action makes zoxamide an important new tool in antiresistance strategies. Can be used as a reference compound.
AdipoGen 4-Hydroxytamoxifen
Chemical. CAS 68392-35-8. Formula C26H29NO2. MW 387.51. 4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator SERM that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist-antagonist of the estrogen receptors ERalpha and ERbeta. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related ERR nuclear receptors beta and gamma. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2 amplitude, slowing relaxation and decreasing contractility. 4-Hydroxytamoxifen has also shown to be a potent inhibitor of the mitochondrial permeability transition MPT.
eMolecules Chem-Impex Thiourea 100kg 112439619 00284 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
Chem-Impex Thiourea 100kg 112439619 00284 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
AdipoGen Zoxamide
Chemical. CAS 156052-68-5. Formula C14H16Cl3NO2. MW 336.6. Synthetic. Fungicide. Primarily an oomycete fungicide although it has some activity against ascomycetes and basidiomycetes. The product acts by disruption of the microtubule structure and inhibition of cell division. The mechanism for this activity is through the covalent binding of the active ingredient to beta-tubulin in the cytoskeleton. Scanning microscopy studies showed zoxamide action against blight on potato crops begins after germination, achieving inhibition of hyphal development and sporangia production. This novel mode of action makes zoxamide an important new tool in antiresistance strategies. Can be used as a reference compound.
AdipoGen 7-OH-4-methyl-21H-quinolone
Chemical. CAS 20513-71-7. Formula C10H9NO2. MW 175.18. Synthetic. 7-Hydroxy-4-methyl-21H-quinolone is a starting material for the synthesis of a potential cytotoxic compound class with activity against human tumor cell lines.
AdipoGen 4-Hydroxytamoxifen
Chemical. CAS 68392-35-8. Formula C26H29NO2. MW 387.51. 4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator SERM that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist-antagonist of the estrogen receptors ERalpha and ERbeta. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related ERR nuclear receptors beta and gamma. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2 amplitude, slowing relaxation and decreasing contractility. 4-Hydroxytamoxifen has also shown to be a potent inhibitor of the mitochondrial permeability transition MPT.
AdipoGen Vandetanib
Chemical. CAS 443913-73-3. Formula C22H24BrFN4O2. MW 475.4. Vandetanib is an orally available, ATP mimetic small molecule tyrosine kinases inhibitor that targets vascular endothelial growth factor receptor-2 VEGFR-2, VEGFR-3 and epidermal growth factor receptor EGFR, REarranged during Transfection RET and slightly VEGFR-1. Inhibition of these tyrosine kinases blocks multiple intracellular signaling pathways involved in tumor growth, proliferation, progression and angiogenesis. It inhibits RET, VEGFR2, VEGFR3, VEGFR1, EGFR, PDGFRbeta, Tie-2, and FGFR1 in cell-free assays IC50s = 34, 40, 110, 1,600, 500, 1,100, 2,500, and 3,600 nM, respectively. It also binds to 142 additional kinases in a panel of 442 kinases Kds = 4.6-7,900 nM. Vandetanib 1 and 2.5 µM induces apoptosis, autophagy, ROS and cell cycle arrest at the G0/G1 phase and has anti-proliferative properties in several cancer cell lines and in in vivo cancer models.
AdipoGen Desacetylcolchicine tartrate
Chemical. CAS 49720-72-1. Formula C20H23NO5 . C4H6O6. MW 357.4 . 150.1. Synthetic. Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.
AdipoGen MS-275
Chemical. CAS 209783-80-2. Formula C21H20N4O3. MW 376.4. HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.
AdipoGen Colcemid
Chemical. CAS 477-30-5. Formula C21H25NO5. MW 371.4. Semisynthetic from colchicine Prod. No. AG-CN2-0048. Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation inactivates spindle fibre formation. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.
AdipoGen Boc-Leu-Arg-Arg-AMC
Chemical. CAS 109358-46-5 free base. Formula C33H52N10O7 . C2H4O2. MW 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues R and K. Excitation 380nm. Emission 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen CTPB
Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
AdipoGen Boc-AspOMe-FMK
Chemical. CAS 187389-53-3. Formula C11H18FNO5. MW 263.3. Synthetic. Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha IC50=39µM. Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
AdipoGen Z-Phe-Arg-AFC
Chemical. CAS 93753-73-2 free base. Formula C33H33F3N6O6 . C2HF3O2. MW 666.7 . 114.0. Synthetic. Fluorogenic substrate, specifically used to determine the enzyme activity of Cathepsin L. Useful for the study of cathepsin activity and for screening small molecule inhibitors for drug discovery and HTS applications. Likely to be cleaved by cathepsins B, F, K, S and L, cathepsins L-like proteases and proteases such as papain, cruzipain, plasma kallikrein, soybean trypsin-like enzyme and the falcipains-1 and -2 malaria hemoglobinases. Hydrolysis of this substrate is monitored by observing fluorescence at an Excitation of 400nm and Emission at 505nm.
AdipoGen Indole-3-carbinol
Chemical. CAS 700-06-1. Formula C9H9NO. MW 147.2. Natural breakdown product of glucosinolates found in cruciferous vegetables. Widely used multifunctional aryl hydrocarbon receptor AhR agonist. AhR is emerging as a transcription factor involved in the regulation of both innate and adaptive immune responses in various immune cell types, including lymphocytes and antigen-presenting cells APCs. Studies have associated overexpression of AHR with the activation of cancer processes such as proliferation, epithelial-to-mesenchymal transition EMT, DNA damage, inflammation, migration and angiogenesis. Used to increase the population of innate lymphoid cells 3 ILC3 in gut microbiota. Chemopreventive agent that has multiple anticarcinogenic and antitumor properties and suppresses the proliferation of selective cancer cells, including breast cancer, prostate cancer, endometrial cancer, colon cancer and leukemic cells. Protects against nephrotoxicity. Proapoptotic.