Thioureas
Biomatik Corporation Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Biomatik Corporation E-64. Grade Biotechnology. Storage -20C. CAS 66701-25-5
E-64. Grade Biotechnology. Storage -20C. CAS 66701-25-5
Biomatik Corporation Indole-3-Butyric Acid [IBA]. Grade Biotechnology. Storage 4C. CAS 133-32-4
Indole-3-Butyric Acid [IBA]. Grade Biotechnology. Storage 4C. CAS 133-32-4
Biomatik Corporation Leupeptin, Hemisulfate Salt. Grade Biotechnology. Storage -20C. CAS 103476-89-7
Leupeptin, Hemisulfate Salt. Grade Biotechnology. Storage -20C. CAS 103476-89-7
Biomatik Corporation Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Biomatik Corporation Leupeptin, Hemisulfate Salt. Grade Biotechnology. Storage -20C. CAS 103476-89-7
Leupeptin, Hemisulfate Salt. Grade Biotechnology. Storage -20C. CAS 103476-89-7
Biomatik Corporation Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Sigma Aldrich Fine Chemicals Biosciences 2-Imidazolidinethione purum, >=98.0% (HPLC) | 96-45-7 | MFCD00005276 | 100G
2-Imidazolidinethione purum, >=98.0% (HPLC) | Purity: >=98.0% (HPLC) | Mol Wt: 102.16 | 96-45-7 | MFCD00005276 | 100G
AdipoGen TPEN
Chemical. CAS 16858-02-9. Formula C26H28N6. MW 424.5. TPEN is a cell permeable metal ion chelator. TPEN is a chelator that has a high affinity for zinc Zn2, next to other transition metals Zn2 >Fe2 >Mn2 and is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. TPEN has lower affinity for Ca2 and Mg2 and can also form complexes with other soft metal ions such as Cd2. In addition to a heavy metal chelator, TPEN is also known to be an apoptosis inducer. Depletion of zinc by TPEN induces apoptosis in several cell lines. TPEN shows anticancer activity through induction of caspase-dependent apoptosis, via reactive oxygen species ROS signaling mechanism and inhibiting cell autophagy. TPEN also inhibits RNA binding protein Lin28 and has been shown to be useful in extracting Abeta depostis from Alzheimers disease brain tissue.
AdipoGen Thapsigargin
Chemical. CAS 67526-95-8. Formula C34H50O12. Molecular Weight 650.75. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs IC50 values are cell type-dependent and range from ~2-80 nM. Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. Thapsigargin shows anti-inflammatory and anti-cancer effects.
AdipoGen PTACH
Chemical. CAS 848354-66-5. Formula C20H26N2O2S2. MW 390.56. Synthetic. Non-hydroxamate HDAC inhibitor HDACi IC50 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively. Cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro EC50 = 1.1 - 9.1mM. Also reactivates latent HIV-1 gene expression.
AdipoGen Ozagrel
Chemical. CAS 82571-53-7. Formula C13H12N2O2. MW 228.2. Synthetic. Ozagrel, an antithrombic drug, is a potent and selective TXA Synthase thromboxane A2 TXAS inhibitor. Acts as a selective inhibitor of TXAS with an IC50=11nM. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke, and antihypertensive effects in spontaneously hypertensive rats.
AdipoGen 4-Methylumbelliferone
Chemical. CAS 90-33-5. Formula C10H8O3. MW 176.17. 4-Methylumbelliferone 4-MU is a selective inhibitor of hyaluronan HA by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan HA is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer. Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 plateau above pH10. The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data lambdaex=360nm lambdaem=448nm pH > 9.
AdipoGen Josamycin
Chemical. CAS 16846-24-5. Formula C42H69NO15. MW 827.99. Synthetic. A member of the leucomycin family of macrolide antibiotics produced by Streptomyces kitasatoensis. May overcome anticancer drug resistance by inhibiting the binding of vinblastine or cyclosporin A to P-glycoprotein Pgp. An antimicrobial against a wide variety of pathogens.
AdipoGen Desacetylcolchicine tartrate
Chemical. CAS 49720-72-1. Formula C20H23NO5 . C4H6O6. MW 357.4 . 150.1. Synthetic. Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.