Cinnamic acids and derivatives
Cayman Chemical CurcumIn-d6 500ug
An internal standard for the quantification of curcumin by GC- or LC-MS
Medchemexpress LLC Tyrphostin AG 528 | 133550-49-9 | MFCD01076474 | 98.0% | 306.32 g·mol^-1 | C18H14N2O3 | 25 MG
Tyrphostin AG 528 is a small-molecule protein tyrosine kinase inhibitor used as a research reagent to probe EGFR and ErbB2 (HER2) signaling pathways. It is supplied as a high-purity solid for biochemical and cellular studies.
- Inhibits EGFR and ErbB2 with reported IC50s of 4.9 μM and 2.1 μM.
- High purity (98.0%) suitable for laboratory research.
- Supplied as a solid, light yellow to yellow in color.
- Molecular weight 306.32 g·mol⁻¹; formula C18H14N2O3.
- Available in small research quantities, including 25 mg packaging.
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.
TARGETMOL CHEMICALS INC BISDEMETHOXYCURCUMIN 50MG
Also available in 5 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis interacting with 1(alpha) 25-dihydroxy vitamin D3 to stimulate amyloid-(beta) clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300 suppressing the Wnt/(beta)-catenin pathway and inhibits LPS induction of iNOS expression [3]. purity: 99%
![Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene] | 116313-73-6 | MFCD00236451 | 98.7% | 231.16 g/mol | C10H5N3O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000248008.png-250.jpg)
Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene] | 116313-73-6 | MFCD00236451 | 98.7% | 231.16 g/mol | C10H5N3O4 | 5 MG
Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in research to modulate signaling pathways. Supplied as a light yellow solid, it inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro and is characterized by formula C10H5N3O4, molecular weight 231.16 g/mol, and typical purity of approximately 98.7%.
- Potent tyrosine kinase inhibition in cellular assays.
- Inhibits ICAM1 expression and TNFα-mediated cytotoxicity.
- High purity suitable for biochemical and cellular studies.
- Available in small milligram-scale packages for laboratory use.
- Solid form with defined appearance for straightforward handling.
Selleck Chemical LLC Curcumin analog C1
Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer s disease
Medchemexpress LLC 4-Hydroxybenzylidenemalononitrile | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 25 MG
Tyrphostin 8 (4-hydroxybenzylidenemalononitrile, CAS 3785-90-8) is a small-molecule tyrosine kinase inhibitor reported to target EGFR, with additional activity against GTPases and the serine/threonine phosphatase calcineurin. Provided for research use in solid and DMSO solution formats, it has molecular formula C10H6N2O, molecular weight 170.17 g/mol, and listed purity 98.0%.
- Reported EGFR inhibitor (IC50 = 560 μM).
- Inhibits calcineurin phosphatase activity (IC50 = 21 μM).
- Also reported to inhibit GTPase activity.
- Supplied as solid and as 10 mM solution in DMSO for assay flexibility.
- Listed purity 98.0% suitable for biochemical research.
- Chemical formula C10H6N2O; molecular weight 170.17 g/mol.
Sigma Aldrich Fine Chemicals Biosciences Bisdesmethoxycurcumin United States Pharmacopeia (USP) Reference Standard | 33171-05-0 | 30MG
Bisdesmethoxycurcumin United States Pharmacopeia (USP) Reference Standard | Mol Wt: 308.33 | 33171-05-0 | 30MG
TARGETMOL CHEMICALS INC Tipifarnib S enantiomer 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50 0.6 nM). Purity 99.05%
Medchemexpress LLC SAR405 R enantiomer | 1946010-79-2 | 99.9% | 443.85 | C19H21ClF3N5O2 | 5MG
SAR405 R enantiomer is the less-active enantiomer of SAR405, a selective ATP-competitive inhibitor of class III PI3K (Vps34) used in research to profile autophagy and endosomal trafficking pathways. The compound is supplied as a high-purity solid and as a 10 mM solution in DMSO, with small pack sizes suitable for in vitro assays. Chemical identifiers: CAS 1946010-79-2; formula C19H21ClF3N5O2; molecular weight 443.85; purity 99.94%.
- Less-active enantiomer for control and stereochemistry studies.
- Selective inhibitor of PIK3C3/Vps34 for autophagy research.
- High purity suitable for biochemical and cell-based assays.
- Available as solid and as a 10 mM DMSO solution ready for use.
- Small pack sizes enable screening and dose-response experiments.
- Includes CAS and molecular data for compound tracking.
TARGETMOL CHEMICALS INC RUXOLITINIB S ENANTIOMER 50MG
Also available in 5 mg 10 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent selective JAK1/2 inhibitor. purity: 99%
Medchemexpress LLC Z-entacapone | 145195-63-7 | 305.29 | C14H15N3O5 | 5 MG
Z-entacapone is the Z-isomer of entacapone and functions as a catechol-O-methyltransferase (COMT) inhibitor supplied for laboratory research use only. The compound is a characterized research reagent with associated documentation to support quality control and safe handling in experimental workflows.
- Research-grade COMT inhibitor for biochemical and pharmacology studies.
- Supplied in small, accurately weighed quantities suitable for assay development.
- Molecular formula C14H15N3O5 and molecular weight 305.29 g/mol.
- Certificate of analysis and documentation available for quality verification.
- Not for human or therapeutic use; for research use only.
Medchemexpress LLC 4-Methoxycinnamic acid | 830-09-1 | 178.19 | 250 G
4-Methoxycinnamic acid | 830-09-1 | 178.19 | 250 G
