Cinnamic acids and derivatives
Medchemexpress LLC HY-N0060 100mg Medchemexpress, Ferulic acid CAS:1135-24-6 Purity:>98%
Medchemexpress, HY-N0060 100mg Ferulic acid CAS:1135-24-6 Ferulic acid is a novel fibroblast growth factor receptor 1 ( FGFR1 ) inhibitor with IC 50 s of 3.78 and 12.5 μM for FGFR1 and FGFR2 , respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-N1387 1g Medchemexpress, 4-Methoxycinnamic acid CAS:830-09-1 Purity:>98%
Medchemexpress, HY-N1387 1g 4-Methoxycinnamic acid CAS:830-09-1 4-Methoxycinnamic acid is detected as natural phenylpropanoid in A. preissii. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Cinnamic acid 621-82-9 200mg
Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection
Apexbio Technology LLC Tyrphostin A1 2826-26-8 50mg
Tyrphostin A1 (CAS 2826-26-8) is a small molecule inhibitor targeting tyrosine kinase activity specifically involved in disrupting intracellular signaling pathways in immune cells It has been shown to interfere with CD40 ligand-induced signaling resulting in suppressed interleukin-12 (IL-12) secretion by macrophages and reduced differentiation of antigen-induced T helper 1 (Th1) cells Tyrphostin A1 is widely utilized in studies investigating cell-to-cell signaling immune response modulation and the mechanisms underlying inflammatory processes particularly in the context of autoimmune disease models
Apexbio Technology LLC (E,E)-Bisdemethoxycurcumin 33171-05-0 5mg
(E E)-Bisdemethoxycurcumin (CAS 33171-05-0) is a naturally derived curcuminoid and a structural analog within the demethoxycurcumin class Research demonstrates that this compound modulates multiple inflammatory signaling pathways and alters the expression of various inflammatory mediators It has been shown to induce cell cycle arrest promote apoptosis in cancer cells and inhibit proliferation-related pathways (E E)-Bisdemethoxycurcumin is widely utilized in studies investigating the molecular mechanisms of inflammation tumor cell biology and the pharmacological properties of curcuminoid derivatives
Apexbio Technology LLC Entacapone 130929-57-6 100mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Apexbio Technology LLC Tyrphostin A1 2826-26-8 25mg
Tyrphostin A1 (CAS 2826-26-8) is a small molecule inhibitor targeting tyrosine kinase activity specifically involved in disrupting intracellular signaling pathways in immune cells It has been shown to interfere with CD40 ligand-induced signaling resulting in suppressed interleukin-12 (IL-12) secretion by macrophages and reduced differentiation of antigen-induced T helper 1 (Th1) cells Tyrphostin A1 is widely utilized in studies investigating cell-to-cell signaling immune response modulation and the mechanisms underlying inflammatory processes particularly in the context of autoimmune disease models
Apexbio Technology LLC Tyrphostin 9 10537-47-0 25mg
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
Apexbio Technology LLC CURCUMIN 10MM IN 1ML DMSO
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
Selleck Chemical LLC Tyrphostin AG-528
Tyrphostin AG-528 (Tyrphostin B66) is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4 9 M and 2 1 M respectively Tyrphostin AG-528 exhibits anticancer activity
Selleck Chemical LLC 4-Hydroxycyclohexanecarboxylic
trans-4-Hydroxycyclohexanecarboxylic acid is used as an organic intermediate
Selleck Chemical LLC a-cyano-4-hydroxycinnamic acid
4-Chloro- -cyanocinnamic acid ( -CHCA) is a classic monocarboxylate transporters (MCT) inhibitor -cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs
eMolecules 2-(3'-Fluorobenzyloxy)phenylboronic acid | 871126-24-8 | 1G | Purity: 98%
Combi-Blocks | 2-(3'-Fluorobenzyloxy)phenylboronic acid | 1G | 871126-24-8 | MFCD07784392
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Cambridge Isotope Laboratories 4-HYDROXY-3-METHOXYCINNAMIC ACID (FERULIC ACID) (1',2',3'-13C3, 99%), 1 MG, 1261170-81-3
4-HYDROXY-3-METHOXYCINNAMIC ACID (FERULIC ACID) (1',2',3'-13C3, 99%), 1 MG, 1261170-81-3
Sigma Aldrich Fine Chemicals Biosciences 4-Formylcinnamic acid, predominantly trans | 23359-08-2 | MFCD00006955 | 5G
4-Formylcinnamic acid, predominantly trans | Mol Wt: 176.17 | 23359-08-2 | MFCD00006955 | 5G