Dihydrocoumarins

Medchemexpress LLC Dihydrocoumarin | 119-84-6 | 148.16 | 1 ML

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Dihydrocoumarin is a compound found in *Melilotus officinalis*. It acts as a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2. This compound induces concentration-dependent inhibition in enzymatic assays, and increases cytotoxicity, apoptosis, and p53 lysine acetylation in the TK6 cell line.

• Yeast Sir2p inhibitor
• Inhibits human SIRT1 and SIRT2
• Increases cytotoxicity and apoptosis in TK6 cell line
• Increases p53 lysine acetylation in TK6 cell line

Medchemexpress LLC Dihydrocoumarin | 119-84-6 | 148.16 | 100 G

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Dihydrocoumarin is a compound found in *Melilotus officinalis*. It is a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2. It is suitable for laboratory research and includes the following features and benefits:

• Inhibits yeast Sir2p
• Inhibits human SIRT1 and SIRT2
• Increases cytotoxicity in the TK6 cell line
• Increases apoptosis in the TK6 cell line
• Increases p53 lysine 373 and 382 acetylation

Medchemexpress LLC Dihydrocoumarin | 119-84-6 | 148.16 | 25 G

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Dihydrocoumarin is a compound found in *Melilotus officinalis*. It acts as a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

• Yeast Sir2p inhibitor
• Inhibits human SIRT1 (IC50 of 208 μM)
• Inhibits human SIRT2 (IC50 of 295 μM)
• Induces concentration-dependent inhibition of SIRT1 in an in vitro enzymatic assay
• Increases cytotoxicity and apoptosis in the TK6 cell line in a dose-dependent manner
• Increases p53 lysine 373 and 382 acetylation in the TK6 cell line

Medchemexpress LLC Dihydrocoumarin (Hydrocoumarin) | 119-84-6 | 148.16 | 50 G

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Dihydrocoumarin is a compound found in Melilotus officinalis. It is a yeast Sir2p inhibitor and also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

• Found in Melilotus officinalis.
• Yeast Sir2p inhibitor.
• Inhibits human SIRT1 (IC50 of 208 μM) and SIRT2 (IC50 of 295 μM).
• Induces concentration-dependent inhibition of SIRT1 in an in vitro enzymatic assay.
• Increases cytotoxicity and apoptosis in the TK6 cell line in a dose-dependent manner.
• Increases p53 lysine 373 and 382 acetylation in the TK6 cell line.