Linear 1 3-diarylpropanoids
1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione 98.0+%, TCI America™
CAS: 70356-09-1 Molecular Formula: C20H22O3 Molecular Weight (g/mol): 310.39 MDL Number: MFCD00210252 InChI Key: XNEFYCZVKIDDMS-UHFFFAOYSA-N PubChem CID: 51040 IUPAC Name: 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione SMILES: COC1=CC=C(C=C1)C(=O)CC(=O)C1=CC=C(C=C1)C(C)(C)C
Medchemexpress LLC AKT inhibitor VIII | 612847-09-3 | MFCD23843802 | 99.0% | 551.64 g/mol | C34H29N7O | 100 MG
AKT inhibitor VIII is a cell-permeable, reversible allosteric inhibitor of Akt kinases used as a research reagent to probe PI3K/Akt signaling pathways. It is supplied as a light yellow solid for laboratory use.
- Allosteric, reversible Akt inhibitor.
- Isoform-selective activity with greater potency for Akt1 and Akt2.
- Reported IC50 values: Akt1 = 58 nM, Akt2 = 210 nM.
- Molecular formula C34H29N7O; molecular weight 551.64 g/mol.
- High reported purity (~99%).
- Supplied as a light yellow solid with recommended storage for powder at -20°C or 4°C depending on duration.
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies