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Macrolides and analogues

Organic compounds characterized by having a lactone ring (14–16 atoms) bonded to one or more deoxy sugar molecules; they are a class of closely related antibiotics. Analogues (compounds with similar structure) are included.

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1

Abcam Epothilone D, Microtubule-stabilizing agent, 5MG

MW 491.7 Da. Microtubule-stabilizing agent. Epothilone A (ab143615) and B (ab141271) analog. Improves microtubule density and axonal integrity Shows antineoplastic and neuroprotective effects in vivo. Blood-brain barrier permeable.

The product is subject to the following: Abcam Restricted Use Statement

ENCOMPASS_PREFERRED
2

Abcam Epothilone D, Microtubule-stabilizing agent, 1MG

MW 491.7 Da. Microtubule-stabilizing agent. Epothilone A (ab143615) and B (ab141271) analog. Improves microtubule density and axonal integrity Shows antineoplastic and neuroprotective effects in vivo. Blood-brain barrier permeable.

The product is subject to the following: Abcam Restricted Use Statement

ENCOMPASS_PREFERRED
3

Abcam Epothilone D, Microtubule-stabilizing agent, 2MG

MW 491.7 Da. Microtubule-stabilizing agent. Epothilone A (ab143615) and B (ab141271) analog. Improves microtubule density and axonal integrity Shows antineoplastic and neuroprotective effects in vivo. Blood-brain barrier permeable.

The product is subject to the following: Abcam Restricted Use Statement

ENCOMPASS_PREFERRED
4

Abcam Epothilone B, Microtubule stabilizing agent, 10UG

MW 507.7 Da, Purity >98%. Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.

The product is subject to the following: Abcam Restricted Use Statement

ENCOMPASS_PREFERRED
5

Abcam Epothilone B, Microtubule stabilizing agent, 100UG

MW 507.7 Da, Purity >98%. Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.

The product is subject to the following: Abcam Restricted Use Statement

ENCOMPASS_PREFERRED