Phenols
Medchemexpress LLC 21-Deoxycortisol | 641-77-0 | 99.6% | 346.46 | 1 ML
21-Deoxycortisol is an endogenous metabolite and a sign of congenital adrenal hyperplasia.
- Purity: 99.62%
- Molecular weight: 346.46
- Chemical formula: C21H30O4
- CAS number: 641-77-0
- Appearance: Solid, white to off-white
- Soluble in DMSO (100 mg/mL)
Apexbio Technology LLC HyperTrap SP HP Column 5x5ml
HyperTrap SP HP Column is a chromatography medium designed for the efficient purification of biomolecules based on strong cation exchange principles The column utilizes sulfopropyl (SP) ligands immobilized on a high-performance matrix allowing selective binding of positively charged proteins and peptides under controlled buffer conditions This mechanism facilitates the separation and enrichment of target analytes from complex biological samples The HyperTrap SP HP Column is commonly applied in protein purification workflows biomarker discovery and quality control assays within biomedical research
Apexbio Technology LLC Dextromethorphan hydrobromide 125-69-9 5g
Dextromethorphan hydrobromide is a small-molecule inhibitor targeting neuronal ion channels including voltage-gated Na and Ca channels and antagonizing N-methyl-D-aspartate (NMDA) receptors It is designed to inhibit voltage-gated inward currents and NMDA receptor-induced currents thereby modulating neuronal excitability and neuroprotection pathways Dextromethorphan hydrobromide exerts its biological activity primarily through inhibition of voltage-gated Na and Ca channels and antagonism of NMDA receptors In cultured cortical neurons dextromethorphan hydrobromide demonstrates inhibition of NMDA receptor-induced currents with an IC value of approximately 80 M Based on these pharmacological properties dextromethorphan hydrobromide holds research potential in the investigation of excitotoxicity neuronal injury mechanisms and therapeutic strategies for ischemic or neurodegenerative conditions
Medchemexpress LLC Oblimersen sodium | 98.09% | 5684.61 (free acid) | 1 MG
Oblimersen sodium functions as a BCL-2 inhibitor by targeting BCL-2 RNA. It specifically binds to the first six codons of the bcl-2 mRNA sequence, leading to the degradation of bcl-2 mRNA and inducing apoptosis by down-regulating the expression of Bcl-2. Oblimersen sodium can be used for cancer research.
- Functions as a BCL-2 inhibitor
- Targets BCL-2 RNA
- Binds to the first six codons of bcl-2 mRNA sequence
- Leads to degradation of bcl-2 mRNA
- Induces apoptosis by down-regulating Bcl-2 expression
- Suitable for cancer research
Medchemexpress LLC BN82002 hydrochloride | 1049740-43-3 | 99.4% | 395.88 | 10 MG
BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It demonstrates significant inhibitory activity against various CDC25 isoforms including CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat, with IC50 values ranging from 2.4 to 6.3 μM. This compound also exhibits high selectivity, showing approximately 20-fold greater inhibition over CD45 tyrosine phosphatase.
- Potent and selective CDC25 phosphatase inhibitor
- Inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat
- Demonstrates approximately 20-fold greater selectivity over CD45 tyrosine phosphatase
- Irreversible inhibitor
Medchemexpress LLC Ifebemtinib (hydrochloride) | 1227948-82-4 | 99.2% | 625.01 | 10 MM/1 ML
Ifebemtinib is an orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (FAK: PTK2) with potential antineoplastic activity. It targets and inhibits PTK2 in an adenosine triphosphate (ATP)-competitive manner, preventing PTK2-mediated downstream signaling and inhibiting migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells.
- Orally bioavailable inhibitor of FAK1/PTK2
- Targets and inhibits PTK2 in an ATP-competitive manner
- Prevents PTK2-mediated downstream signaling
- Inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells
- Stable under recommended storage conditions
Apexbio Technology LLC HyperTrap Q FF Column 5x5ml
The HyperTrap Q FF Column is not a small molecule but a chromatography medium designed for the purification of biomolecules particularly proteins and nucleic acids It operates via strong anion exchange chromatography utilizing quaternary ammonium functional groups immobilized on a Fast Flow resin matrix to selectively bind negatively charged molecules under defined buffer conditions This allows for efficient separation and recovery of target biomolecules from complex mixtures The HyperTrap Q FF Column is applied in research settings for desalting buffer exchange and isolation of nucleic acids or proteins supporting downstream analyses and preparative workflows in the biomedical field
Apexbio Technology LLC HyperTrap Glutathione 4FF Column 5x5ml
The HyperTrap Glutathione 4FF Column is a specialized affinity chromatography medium designed for the selective binding and purification of glutathione S-transferase (GST)-tagged proteins and glutathione-reactive biomolecules The column utilizes immobilized glutathione on a highly cross-linked 4FF agarose matrix enabling efficient capture of GST fusion proteins through specific glutathione-protein interactions This technology supports downstream applications such as protein purification functional characterization and interaction studies in molecular biology and biochemistry research The column s high binding capacity and stability make it suitable for preparative and analytical workflows requiring selective protein isolation
Apexbio Technology LLC HyperTrap Q HP Column 5ml
HyperTrap Q HP Column is not a small molecule but a high-performance chromatography column designed for biomolecule purification Featuring a strong anion exchange resin with quaternary ammonium functional groups the column enables efficient separation and capture of negatively charged biomolecules such as proteins and nucleic acids based on their charge properties The column supports high binding capacity and robust performance across a range of pH conditions making it suitable for process development scale-up and routine purification workflows in biomedical research particularly for the preparation and analysis of protein therapeutics and other biologically relevant molecules
Apexbio Technology LLC Ibandronate sodium 138926-19-9 10mM (in 1mL H2O)
Ibandronate sodium (CAS 138926-19-9) is a nitrogen-containing bisphosphonate that selectively inhibits farnesyl pyrophosphate synthase within the mevalonate pathway thereby disrupting osteoclast-mediated bone resorption By impairing osteoclast function and survival ibandronate sodium effectively reduces bone turnover This compound is widely utilized in biomedical research to investigate mechanisms related to bone metabolism remodeling and diseases characterized by excessive bone resorption such as osteoporosis Its precise inhibitory profile makes it a valuable tool for studies on osteoclast biology and bisphosphonate pharmacodynamics
Apexbio Technology LLC Cytochrome c fragment (93-108) 1mg
Cytochrome c fragment 93-108 is a peptide derived from cytochrome c a mitochondrial protein involved in apoptosis It is designed to interact with apoptotic protease activating factor-1 (Apaf-1) thereby promoting the assembly of the Apaf-1/caspase-9 apoptosome complex and regulating the caspase activation pathway Cytochrome c fragment 93-108 exerts its biological activity primarily through activation of the caspase cascade specifically the activation of caspase-9 and subsequent caspase-3 Based on these pharmacological properties cytochrome c fragment 93-108 holds research potential in studies of apoptosis-related signaling networks caspase activation pathways and drug screening targeting apoptosis regulators
Apexbio Technology LLC Mexiletine HCl 5370-01-4 10mM (in 1mL DMSO)
Mexiletine hydrochloride (CAS 5370-01-4) is a small molecule classified as a Class IB anti-arrhythmic agent It modulates cardiac electrophysiological activity primarily by inhibiting voltage-gated sodium channels resulting in decreased inward sodium currents during the cardiac action potential Through this mechanism mexiletine HCl stabilizes cardiac cell membranes and suppresses abnormal electrical activity This compound is frequently utilized in research to study sodium channel function cardiac arrhythmia models and the pharmacodynamics of anti-arrhythmic interventions
Apexbio Technology LLC Dicyclomine HCl 67-92-5 5g
Dicyclomine Hydrochloride (CAS 67-92-5) is an orally active muscarinic acetylcholine receptor antagonist that primarily interacts with the M1 and M2 receptor subtypes It exhibits high binding affinity for the M1 subtype (Ki 5 nM) and moderate affinity for M2 receptors (Ki 55 nM) By inhibiting these receptors Dicyclomine HCl is utilized in studies investigating muscarinic receptor-mediated signal transduction Additionally it is commonly employed in pharmacological and pathophysiological research involving gastrointestinal smooth muscle spasm and related mechanisms