Phenols
Medchemexpress LLC Lesogaberan (hydrochloride) | 2925644-17-1 | 98.0% | 177.54 | 5 MG
Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABAB receptor agonist, with an EC50 of 8.6 nM for human recombinant GABAB receptors. It demonstrates high affinity for rat GABAB receptors (Ki: 5.1 nM) and inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. This compound has been shown to enhance human islet cell proliferation in vitro and protect human islet β-cells from apoptosis in islet grafts in mice. Lesogaberan hydrochloride exhibits high oral availability (88% in dogs, 100% in rats) and relatively low systemic clearance in rats, making it suitable for research applications.
- Potent and selective GABAB receptor agonist
- Inhibits transient lower esophageal sphincter relaxation
- Enhances human islet cell proliferation in vitro
- Protects human islet β-cells from apoptosis in islet grafts in mice
- High oral availability and low systemic clearance
Medchemexpress LLC Varenicline dihydrochloride | 866823-63-4 | 99.2% | 284.18 g/mol | C13H15Cl2N3 | 5 MG
Varenicline dihydrochloride is the dihydrochloride salt of a nicotinic acetylcholine receptor ligand used in research as a partial agonist at α4β2 receptors. Supplied as a solid powder for in vitro pharmacology, assay development, and reference standard applications, it offers consistent, well-characterized behavior for receptor-binding and functional studies.
- High purity (99.2%) for research-grade use.
- Dihydrochloride salt form for improved solubility in aqueous media.
- Partial agonist at α4β2 nicotinic acetylcholine receptors, useful for studies of receptor pharmacology.
- Known molecular weight (284.18 g/mol) and CAS number (866823-63-4) for unambiguous identification.
- Supplied in small solid quantities suitable for assay development and reference standards.
Apexbio Technology LLC Pramoxine HCl 637-58-1 10mM (in 1mL DMSO)
Pramoxine HCl is a local anesthetic that transiently inhibits sensory nerve signal conduction through sodium channel blockade in neuronal membranes thereby reducing local sensory nerve impulses and producing anesthetic and antipruritic effects Pramoxine HCl exerts its biological activity primarily through sodium channel blockade Based on these pharmacological properties Pramoxine HCl holds research potential in the investigation of sensory nerve inhibition mechanisms pruritus management and in vitro nerve conduction assays
Medchemexpress LLC N,N'-Carbonyldiimidazole | 530-62-1 | 99.9% | C7H6N4O | 500 G
N,N'-Carbonyldiimidazole (1,1'-Carbonyldiimidazole) is a highly reactive carboxylating reagent. It activates hydroxyl groups to form reactive carbonyl groups and functions as a coupling agent and peptide synthesis reagent. In vitro, it mediates the conjugation of ovalbumin with magnetite nanoparticles for vaccine delivery.
- Highly reactive carboxylating reagent
- Activates hydroxyl groups to form reactive carbonyl groups
- Can be used as a coupling agent
- Functions as a peptide synthesis reagent
- Mediates conjugation of ovalbuminn with magnetite nanoparticles for vaccine delivery in vitro
Medchemexpress LLC Tropolone | 533-75-5 | 25 G
Tropolone is a seven-membered non-benzenoid aromatic compound and a precursor of many Azulene derivatives. It is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Tropolone also shows broad anti-viral and anti-fungal activity and is synergistic when co-treated with nucleos(t)ide analog drugs. It is a promising candidate for research in osteosarcoma.
- Potent mushroom tyrosinase inhibitor (IC50: 0.4 μM)
- Exhibits broad anti-viral and anti-fungal activity
- Synergistic upon co-treatment with nucleos(t)ide analog drugs
- Promising candidate for research in osteosarcoma
Apexbio Technology LLC L-798,106 244101-02-8 50mg
L-798 106 (CAS 244101-02-8) is a highly selective antagonist of the prostaglandin E2 (EP3) receptor Binding studies demonstrate a strong affinity for the EP3 receptor with a Ki of 0 3 nM while showing substantially reduced affinity for EP1 ( 5000 nM) EP2 ( 5000 nM) and EP4 (916 nM) receptors By selectively inhibiting EP3 receptor-mediated signaling L-798 106 is utilized to investigate the physiological and pathological roles of EP3 in various disease models and serves as a molecular tool in the preclinical evaluation of EP3-targeted therapeutic strategies
Medchemexpress LLC Talipexole dihydrochloride | 36085-73-1 | 99.80% | C10H17Cl2N3S | 5 MG
Talipexole dihydrochloride is a dopamine D2 receptor agonist, an α2-adrenoceptor agonist, and a 5-HT3 receptor antagonist. This compound displays anti-Parkinsonian activity and is a white to off-white solid.
- Targets dopamine D2 receptors
- Acts as an α2-adrenoceptor agonist
- Functions as a 5-HT3 receptor antagonist
- Exhibits anti-Parkinsonian activity
- Soluble in DMSO (25 mg/mL)
- Involved in GPCR/G protein and neuronal signaling pathways
- For research use only
Medchemexpress LLC PrP (106-126) | 148439-49-0 | 99.6% | 1912.30 | 10 MG
PrP (106-126) is a peptide corresponding to the prion protein (PrP) amyloidogenic region. Its biochemical properties are similar to the infectious form of prion protein. This product is for research use only.
- Corresponds to the prion protein (PrP) amyloidogenic region
- Biochemical properties resemble the infectious form of prion protein
- Induces mTOR phosphorylation in N2a cells
- Increases ROS production
- Interacts selectively with porcine brain endothelial cells
- Reduces trans-endothelial electrical resistance