Carboxylic acids and derivatives
Medchemexpress LLC Dizocilpine maleate | 77086-22-7 | C20H19NO4 | 1 ML
Dizocilpine maleate (MK-801 maleate) is a potent, selective, and non-competitive antagonist of the NMDA receptor. It has a Kd of 37.2 nM in rat brain membranes and causes a progressive, long-lasting blockade of N-Me-D-Asp and NMDA-induced currents.
- Potent, selective, and non-competitive NMDA receptor antagonist
- Blocks NMDA-activated single-channel activity
- Inhibits activation of microglia induced by LPS
- Reduces microglial TNF-α output
- Can be used to induce schizophrenia models
Medchemexpress LLC DG013A (formate) | 00-00-0 | 99.6% | 530.99 g/mol | C27H37N4O4P · 2/5CH2O2 | 5 MG
DG013A (formate) is a phosphinic acid tripeptide mimetic inhibitor of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2, used as a biochemical probe in studies of antigen processing, autoimmune disease, and cancer research. Reported biochemical potency supports use in enzyme inhibition assays and target-validation studies.
- Phosphinic acid tripeptide mimetic inhibitor of ERAP enzymes.
- Potent activity: ERAP1 IC50 33 nM, ERAP2 IC50 11 nM.
- High purity by LCMS: 99.6%.
- Molecular weight: 530.99 g/mol.
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Provided for research use; not for human or clinical use.
Apexbio Technology LLC Menadiol Diacetate 573-20-6 1g
Menadiol Diacetate (CAS 573-20-6) is a synthetic derivative of vitamin K investigated for its regulatory effects on cellular signaling pathways and enzyme activities In experimental studies Menadiol Diacetate has been shown to induce S phase arrest in the cell cycle leading to apoptotic cell death This compound is utilized in research focused on cancer and related diseases providing a tool for exploring mechanisms of cell proliferation and apoptosis in vitro
Apexbio Technology LLC Sulforhodamine 101 60311-02-6 25mg
Sulforhodamine 101 (60311-02-6) is a red-emitting fluorescent dye primarily utilized as a selective marker for astrocytes Sulforhodamine 101 selectively accumulates in astrocytes enabling differentiation from surrounding neuronal populations In neurobiological studies using live tissue imaging including acute brain slice preparations the dye facilitates visualization of astroglial cell morphology and cellular dynamics Based on these properties Sulforhodamine 101 holds research potential in the study of astrocyte-specific responses morphological characteristics and cell cell interactions within neuronal tissues
Apexbio Technology LLC Cefazolin (sodium salt) 27164-46-1 500mg
Cefazolin sodium salt (CAS 27164-46-1) is a semisynthetic antibiotic that inhibits bacterial cell wall synthesis by binding to specific penicillin-binding proteins thereby blocking transpeptidation reactions essential for peptidoglycan formation In in vitro studies cefazolin sodium salt suppresses the proliferation of cultured osteoblast-like MG-63 cells exhibiting substantial cytotoxicity at concentrations of 10 000 g/ml precise IC50 values depend on cell type and experimental conditions Cefazolin sodium salt is commonly used in microbiology pharmacokinetic investigations and infection models particularly within studies of antimicrobial susceptibility and renal dysfunction
Selleck Chemical LLC Fumonisin B1
Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme Sheldon and a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) an enzyme vital for the de novo synthesis of sphingolipids It exhibits an IC50 of 0 1 M for N-acyltransferase (ceramide synthase) in rat liver microsomes and also reduces the conversion of [3H]sphingosine to [3H]ceramide in intact hepatocytes
![eMolecules 855863-93-3 | Pharmablock | 3-[(tert-butoxy)carbonyl]aminocyclopentane-1-carboxylic acid | 25mg | 721310997 | PBZ6859 | MFCD02093997 | 229.276 | C11H19NO4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502514365.JPG-250.jpg)
eMolecules 855863-93-3 | Pharmablock | 3-[(tert-butoxy)carbonyl]aminocyclopentane-1-carboxylic acid | 25mg | 721310997 | PBZ6859 | MFCD02093997 | 229.276 | C11H19NO4
Pharmablock | 3-[(tert-butoxy)carbonyl]aminocyclopentane-1-carboxylic acid | 25mg | 721310997 | PBZ6859 | 855863-93-3 | MFCD02093997 | 229.276 | C11H19NO4
Apexbio Technology LLC Toremifene Citrate 89778-27-8 10mM (in 1mL DMSO)
Toremifene Citrate (CAS 89778-27-8) is a small-molecule selective estrogen receptor modulator (SERM) targeting estrogen receptors It is designed to modulate estrogen receptor signaling pathways thereby regulating estrogen-dependent cellular functions Toremifene Citrate exerts its biological activity primarily through tissue-specific antagonism or partial agonism of the estrogen receptor In in vitro studies Toremifene Citrate demonstrates receptor binding activity with an affinity of 1 M for the estrogen receptor Based on these pharmacological properties Toremifene Citrate holds research potential in investigating estrogen-dependent regulatory processes and endocrine signaling dynamics
eMolecules 132622-69-6 | Ambeed | (2S4R)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid | 100mg | 596568677 | A428721 | 230.264 | C10H18N2O4
ChemScene | (6-Chloro-4-(cyclopropylamino)pyridin-3-yl)methanol | 100mg | 768994205 | CS-0616812 | 1588424-64-9 | 198.650 | C9H11ClN2O
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eMolecules SITAGPLIPTIN MONOHYDRATE | 654671-77-9 | MFCD10001393 | 25g
AstaTech | SITAGPLIPTIN MONOHYDRATE | 25g | 624127118 | 41070 | 99.000 | 654671-77-9 | MFCD10001393 | 523.329 | C16H20F6N5O6P
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eMolecules 461-56-3 | 3-FLUOROPROPANOIC ACID | MFCD01695563 | 1g
ChemScene | (R)-2-Amino-2-methylpent-4-enoic acid | 100mg | 711937719 | CS-0089885 | 96886-56-5 | MFCD00153479 | 129.159 | C6H11NO2
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