Carboxylic acids and derivatives
Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 50 MG
Neratinib maleate (HKI-272 maleate) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor. It is intended for research use only.
- Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM, respectively.
- Demonstrates antiproliferative effects in cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase in BT474 cells.
- Inhibits MAPK and Akt phosphorylation, and induces p27.
- Exhibits anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
- Reduces tumor growth in xenograft models.
Medchemexpress LLC Setiptiline (maleate) | 85650-57-3 | 99.9% | 377.43 | 100 MG
Setiptiline maleate is a serotonin receptor antagonist. It is classified as a tetracyclic antidepressant (TeCA) and acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It functions as a norepinephrine reuptake inhibitor, an α2-adrenergic receptor antagonist, and a serotonin receptor antagonist, potentially targeting the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes. Additionally, it acts as an H1 receptor inverse agonist/antihistamine. It is intended for research use only.
- Serotonin receptor antagonist
- Tetracyclic antidepressant (TeCA)
- Noradrenergic and specific serotonergic antidepressant (NaSSA)
- Norepinephrine reuptake inhibitor
- Alpha2-adrenergic receptor antagonist
- Antagonizes serotonin receptor subtypes: 5-HT2A, 5-HT2C, and/or 5-HT3
- H1 receptor inverse agonist/antihistamine
- Purity: 99.94%
- Appearance: Solid
- Color: White to gray
TARGETMOL CHEMICALS INC FLUPIRTINE MALEATE 200MG
Also available in 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Flupirtine maleate (Katadolon maleate) a centrally acting non-opioid analgesia is the salt form of Flupirtine. It is an NMDA receptor antagonist and also a specific neuronal potassium channel opener. purity: 99%
Sigma Aldrich Fine Chemicals Biosciences Sodium pyruvate powder, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99% | 113-24-6 | MFCD00002586 | 25G
Sodium pyruvate powder, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99% | Purity: >=99% | Mol Wt: 110.04 | 113-24-6 | MFCD00002586 | 25G
Medchemexpress LLC TRPM8 antagonist 3 | 2102179-29-1 | 99.5% | C13H12N2O4S | 10MG
TRPM8 antagonist 3 is a potent, selective small-molecule blocker of the TRPM8 ion channel used as a research tool to study cold-sensing and nociception pathways. It shows nanomolar potency (IC50 = 11 nM), a molecular formula of C13H12N2O4S, and is supplied as a high-purity material for in vitro and preclinical research.
- Potent TRPM8 channel blocker with IC50 = 11 nM.
- High purity suitable for research (99.5%).
- Supplied as a solid with option for DMSO solution for easy assay preparation.
- Intended for in vitro and preclinical studies of cold sensation and pain pathways.
- Available in multiple pack sizes to support different experimental scales.
Sigma Aldrich Fine Chemicals Biosciences Sodium glycochenodeoxychol10G
Sodium glycochenodeoxychol10G
Medchemexpress LLC HY-13324 200mg , Bardoxolone (methyl) NSC 713200;RTA 402;CDDO Methyl ester CAS:218600-53-4 Purity:98%
Medchemexpress, HY-13324 200mg Bardoxolone (methyl) NSC 713200;RTA 402;CDDO Methyl ester CAS:218600-53-4 Formula:C32H43NO4 Purity:98% Bardoxolone (methyl) is a potent activator of the nuclear factor erythroid 2-related factor 2 ( Nrf2 ), and uesd for antioxidative and anti-inflammatory treatment. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Enalapril maleate | 76095-16-4 | 100.0% | 1 ML
Enalapril maleate is an active metabolite of enalapril and a potent angiotensin-converting enzyme (ACE) inhibitor. As a prodrug, it is rapidly metabolized to enalaprilat, which helps regulate blood pressure by targeting the renin-angiotensin-aldosterone system (RAAS). It is used in the treatment of essential or renovascular hypertension and symptomatic congestive heart failure.
- Active metabolite of enalapril
- Angiotensin-converting enzyme (ACE) inhibitor
- Prodrug that converts to enalaprilat
- Potent and competitive ACE inhibitor
- Used to treat hypertension
- Used to treat congestive heart failure
Medchemexpress LLC Pirepemat fumarate | 2251806-70-7 | 98.3% | C15H17F2NO5 | 10MG
Pirepemat fumarate is the fumarate salt of pirepemat (IRL752), a cortical-preferring catecholamine- and cognition-promoting research compound investigated for reducing falls and improving cognitive and motor function in Parkinson's disease. The compound is provided as a stable fumarate salt and is used in preclinical and clinical research to modulate cortical neurotransmitter signaling.
- Fumarate salt for improved chemical stability.
- Cortical-preferring catecholamine and cognition-promoting activity.
- Investigated for reduction of falls and improvement of balance in Parkinson's disease.
- Shown to enhance cortical dopamine, acetylcholine, and norepinephrine transmission.
- Supplied in solid and DMSO solution formats for flexible dosing and formulation.
- High purity suitable for research applications.
Apexbio Technology LLC (+)-MK 801 Maleate 77086-22-7 10mg
( )-MK 801 Maleate is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor exhibiting a Ki value of approximately 30 5 nM By blocking the NMDA receptor-mediated ion channel MK 801 disrupts glutamate-associated excitatory neurotransmission In experimental models MK 801 demonstrates anticonvulsant and anxiolytic properties through modulation of NMDA receptor activity This compound readily penetrates the central nervous system binding reversibly and region-specifically to cortical and hippocampal membranes MK 801 effectively inhibits NMDA-triggered depolarization responses in neuronal preparations making it applicable in studies focused on epilepsy excitotoxicity and neuronal signaling pathways
Medchemexpress LLC Quipazine maleate | 5786-68-5 | >98% | 50 MG
Quipazine maleate is a 5-HT agonist that causes behavioral changes such as hyperactivity. It also shows a weak reversible MAO inhibitory activity. This piperazine-based nonselective serotonin receptor agonist targets several 5-HT receptor subtypes, including 5-HT₂A (pKi ≈ 6.9), 5-HT₂C (≈ 7.27), and 5-HT₂B, as well as showing marked agonist activity at 5-HT₃ (EC₅₀ ≈ 1.0 nM). It has been explored for anti-parkinsonian potential in preclinical settings and is a valuable pharmacological tool for studying serotonin receptor functions.
- 5-HT agonist
- Causes behavioral changes such as hyperactivity
- Weak reversible MAO inhibitory activity
- Nonselective serotonin receptor agonist
- Targets 5-HT₂A, 5-HT₂C, 5-HT₂B, and 5-HT₃ receptors
- Explored for anti-parkinsonian potential
- Valuable pharmacological tool for studying serotonin receptor functions
Sigma Aldrich Fine Chemicals Biosciences SB 415286 >=98% (HPLC) | 264218-23-7 | MFCD04039789 | 5MG
SB 415286 >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 359.72 | 264218-23-7 | MFCD04039789 | 5MG