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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
TH-6 is a potent histone deacetylase (HDAC) inhibitor intended for research applications. It inhibits multiple HDAC isoforms, induces apoptosis, causes G2/M cell cycle arrest, and demonstrates antiproliferative and antitumor activity in preclinical models.
Potent HDAC inhibition with submicromolar to low micromolar IC50s.
Inhibits cell migration and invasion in cancer cell models.
Induces apoptosis and G2/M phase cell cycle arrest.
Inhibits tubulin polymerization (IC50 4.06 μM) and increases acetylated α-tubulin and histone H3 levels.
Supplied as a light yellow to khaki solid with 95.0% purity.
Molecular weight 429.44; formula C22H24FN3O5; CAS 3031349-25-1.
Soluble in DMSO at 50 mg/mL (requires warming and sonication).
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More