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Y-27632 dihydrochloride is an ATP-competitive inhibitor of Rho-associated protein kinases (ROCK) used in research to modulate cytoskeletal dynamics, cell morphology, and motility in vitro and in vivo. It is supplied as a high-purity, white to off-white solid suitable for laboratory assays and preclinical studies.
ATP-competitive ROCK inhibitor (ROCK-I Ki = 220 nM; ROCK-II Ki = 300 nM).
Orally active; applicable to in vivo and in vitro studies.
High purity (≈99.9%) for reproducible experimental results.
Molecular weight 320.26 g/mol for stoichiometric calculations.
White to off-white solid; convenient handling and storage.
Available in small research quantities suitable for assay development.
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Atopaxar is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. As an antiplatelet agent, it interferes with platelet signaling and can be used for the research of atherothrombotic disease.
Potent, orally active, selective and reversible PAR-1 antagonist
Interferes with platelet signaling
Used for research of atherothrombotic disease
Inhibits human platelet aggregation induced by thrombin or TRAP
Does not inhibit PRP aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to 20 μM
Causes dose-dependent prolongation of time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model
Does not prolong bleeding time in guinea pigs at high dosages
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More