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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
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Famciclovir (104227-87-4) is an orally available small-molecule prodrug of penciclovir targeting viral DNA polymerase It is designed to enhance the bioavailability of penciclovir thereby improving inhibition of herpesvirus replication Famciclovir exerts its biological activity primarily through selective inhibition of herpes simplex virus (HSV) DNA polymerase by penciclovir which competes with natural nucleotides In cell-based assays famciclovir-generated penciclovir demonstrates potent antiviral activity with reported IC50 values ranging from 0 1 to 0 8 g/mL Based on these pharmacological properties famciclovir holds research potential in studies of HSV and varicella-zoster virus (VZV) infections
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1-(4-Chlorophenyl)piperazine is a chemical intermediate designed for research use. It can be utilized for the synthesis of D2R ligand and is provided as a solid, ranging in color from white to light yellow.
Can be used for the synthesis of D2R ligand
For research use only
Ships at room temperature
Available as a solid, white to light yellow appearance
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Atopaxar is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. As an antiplatelet agent, it interferes with platelet signaling and can be used for the research of atherothrombotic disease.
Potent, orally active, selective and reversible PAR-1 antagonist
Interferes with platelet signaling
Used for research of atherothrombotic disease
Inhibits human platelet aggregation induced by thrombin or TRAP
Does not inhibit PRP aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to 20 μM
Causes dose-dependent prolongation of time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model
Does not prolong bleeding time in guinea pigs at high dosages
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