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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
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GAL-02-221 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. It can potently degrade BRD4 in HER2 positive and negative breast cancer cell lines.
Potently degrades BRD4
Degrades BRD4 in HER2 positive and negative breast cancer cell lines
Connected by ligands for von Hippel-Lindau and BRD4
Shows antiproliferative activity against human 22Rv1, L02, MCF7, and MDA-MB-231 cells
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1,3-Oxazolidine-2-thione (CAS 5840-81-3) is a small-molecule oxazolidinethione used as a research reagent. It is a low-molecular-weight compound (C3H5NOS, 103.14 g·mol⁻¹) supplied at high purity for laboratory studies. It has been reported to increase thyroid size and to markedly depress hepatic trimethylamine oxidase activity in avian models. For research use only.
High purity suitable for analytical and biological research.
Well-characterized molecular properties for reproducible experiments.
Available in small pack sizes for screening and mechanistic studies.
Reported biological activity relevant to endocrine and hepatic research.
Intended for research use only; not for human or veterinary use.
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Cytochrome P450 CYP1B1 190-198 is a tumor-associated antigen peptide derived from CYP1B1 It is designed to induce HLA-A2-restricted T-cell responses against the CYP1B1(190-198) epitope thereby promoting tumor-specific cytotoxic immune responses Cytochrome P450 CYP1B1 190-198 exerts its biological activity primarily through antigen-specific activation of CD8 T cells In HLA-A2 transgenic mouse models this peptide delivered via plasmid DNA and poly(lactide-co-glycolide) microparticles demonstrates the ability to elicit CYP1B1 peptide-specific T-cell immunity Based on these pharmacological properties Cytochrome P450 CYP1B1 190-198 holds research potential in cancer immunotherapy and studies of tumor-specific cytotoxic T-cell responses
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