VB124 is an orally active, potent, and selective MCT4 inhibitor. It specifically inhibits lactate efflux in MDA-MB-231 cells with IC50s of 8.6 nM for lactate import and 19 nM for lactate export. Highly selective for MCT4 over MCT1, this compound is suitable for research into cardiac hypertrophy, heart failure, and metabolism.
- Specifically inhibits lactate efflux
- Highly selective for MCT4 over MCT1
- Inhibits cell proliferation
- Attenuates cardiac hypertrophy in mice
- No overt toxicities observed in tested animal models