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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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6A-azido-6A-deoxy-β-cyclodextrin is a mono-substituted β-cyclodextrin bearing an azide functional group at the 6A position. It is a water-soluble derivative commonly used as a linker in click chemistry for bioconjugation and for host-guest complexation studies.
Contains an azide group for CuAAC and SPAAC click reactions.
High purity (98.0%).
Water-soluble mono-substituted β-cyclodextrin.
Suitable for bioconjugation and host-guest complexation studies.
Solid form for straightforward handling and weighing.
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SP-141 is a specific inhibitor of MDM2. It promotes MDM2 auto-ubiquitination and degradation. This compound may be used for the research of pancreatic cancer and breast cancer cells.
Specific inhibitor of MDM2.
Promotes MDM2 auto-ubiquitination and degradation.
Potential for research in pancreatic cancer and breast cancer cells.
Inhibits human pancreatic cancer cell growth with IC50 values of less than 0.5 μM in a p53-independent manner.
Shows selective cytotoxicity for cancer cells.
Induces MDM2 auto-ubiquitination and proteasomal degradation.
Suppresses pancreatic tumor growth in both xenograft and orthotopic mouse models.
Reduced tumor volume by 75% in a pancreatic xenograft model without significant differences in body weight in one study.
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